Clinical trials: GFR
Type 2 Diabetes Mellitus MeSH:D003924, Periodontitis MeSH:D010518
Non-surgical Periodontal Therapy and Kidney Outcomes in Type 2 Diabetes Mellitus
Brief Summary (Lay Description) This research study is being conducted to understand whether treating gum disease (periodontitis) can help improve kidney health in patients who have type-2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes Mellitus MeSH:D003924, Periodontitis MeSH:D010518, Diabetic Nephropathies MeSH:D003928
- Trial name
- KIDPER (NCT07256613)
- Testing
- scaling and root planning
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Dow University of Health Sciences
Carcinoma, Non-Small-Cell Lung
E GFR TKI and EGF-P TI C Ombination in EGFR mutA nt NSCL C
This is a multicentre, open-label, uncontrolled, Phase Ib clinical study. Patients who give informed consent will be screened for the study, including genotyping of the tumour and baseline characteristics.
- Trial name
- EPICAL (NCT03623750)
- Testing
- EGFR-TK Inhibitor, EGF-PTI, Cyclophosphamide
- Where
- 4 sites in Spain
- Volunteers
- 23 people
- Sponsor
- Instituto Oncológico Dr Rosell
Spinal Cord Injuries, Renal Failure
S-cystatin C vs.Injection Clearance Measurements to Estimate Kidney Function in Patients With Spinal Cord Injuries
In individuals with spinal cord injury (SCI) kidney function defined as Glomerular Filtration Rate (GFR) is monitored by injection of e.g.99mDTPA and subsequent blood sampling (DTPA-clearance) GFR calculated from plasma samples…
- Trial name
- NCT06565351
- Testing
- eGFR estimated from creatinine and cystatin C
- Where
- Denmark
- Volunteers
- 248 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
HIV Infections, AIDS
HIV and Kidney Function Study
Current methods to assess kidney function have not been tested in people who have HIV/AIDS population. Given effects of the disease as well as potential effects of the medications, it is possible that the methods currently used…
- Trial name
- NCT00905151
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Tufts Medical Center
Autosomal Dominant Polycystic Kidney Disease (ADPKD
Lanreotide In Polycystic Kidney Disease Study
LIPS study (Lanreotide In Polycystic kidney disease Study) is a prospective randomized double blind placebo controlled study. The main objective is to prove that lanreotide, a somatostatin analog, is able to reduce the glomerular…
- Trial name
- LIPS (NCT02127437)
- Testing
- Lanreotide, saline
- Where
- France
- Volunteers
- 159 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transplantation, Kidney, Graft Occlusion, Vascular
GFR Measurement With Contrast-enhanced Dynamic MRI
The aim of the study is to optimize and validate this MR-based GFR measurement in patients with a renal transplant, compared with the reference method, the Cr51- EDTA method: to select the most accurate combination of…
- Trial name
- IREN (NCT00614081)
- Testing
- Contrast-enhanced dynamic MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Bordeaux
Chronic Kidney Disease
Assessment of Dialysis Initiation by a Fuzzy Mathematics Equation
The purpose of this study is to evaluate the impact of the optimal and late initiation of dialysis on the mortality and quality of life in end-stage renal disease (ESRD) patients by the Dialysis Initiation based on Fuzzy…
- Trial name
- ADIFE (NCT03385902)
- Testing
- optimal start time, late start time
- Where
- China
- Volunteers
- 388 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Renal Artery Obstruction, Stents
Compare Effects of Intensive Versus Conventional Lipid-lowering Therapy in Patients With Severe Atherosclerotic Renal Artery Stenosis Undergoing Stent Placement
Although expert consensuses recommend the use of statins in the treatment of atherosclerotic renal artery stenosis, in patients with severe atherosclerotic renal artery stenosis undergoing stent placement, the related…
- Conditions
- Renal Artery Obstruction, Stents, Lipids, Glomerular Filtration Rate
- Trial name
- NCT03521700
- Testing
- Rosuvastatin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Obesity, Metabolic Syndrome
Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity.
- Trial name
- NCT02271568
- Testing
- Bariatric surgery, Intensive medical therapy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Hanyang University
Congenital Solitary Kidney
Long Term Outcome of Congenital Solitary Kidney
Congenital solitary kidney (CSK) is a disorder caused by an abnormal development of one of the two kidneys. The reported incidence ranges between 1:450-3200. It is debated whether CSK is a benign condition or not.
- Trial name
- CSKP (NCT01831141)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Kidney Diseases, Diabetes Mellitus, Type 2
Stem Cell Therapy for Chronic Kidney Disease
The purpose of this study is to assess the safety and tolerability of allogeneic mesenchymal stem / stromal cell therapy in individuals with chronic kidney disease.
- Conditions
- Chronic Kidney Diseases, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Diabetes Mellitus
- Trial name
- NCT04869761
- Testing
- Allogeneic adipose-derived mesenchymal stem cells (MSC)-Single Infusion, Allogeneic adipose-derived mesenchymal stem cells (MSC)-Two Infusions
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- LaTonya J. Hickson
Type1diabetes, Type1 Diabetes Mellitus
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
Over 1.25 million Americans have Type 1 Diabetes (T1D), increasing risk for early death from cardiovascular disease (CVD). Despite advances in glycemic and blood pressure control, a child diagnosed with T1D is expected to live up…
- Conditions
- Type1diabetes, Type1 Diabetes Mellitus, Diabetic Kidney Disease, Juvenile Diabetes
- Trial name
- COFFEE (NCT03878277)
- Testing
- Starbucks® Cold brew - 325ml bottle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Heart Failure
Optimal Balance Alfapump® System Feasibility Study
1. Summary of Clinical Investigation A summary of the clinical investigation is provided below and includes the primary objective of the study, the safety and feasibility endpoints, the number of subjects to be enrolled, the…
- Trial name
- OPTIMALBALANCE (NCT03032211)
- Testing
- Alfapump
- Where
- Hungary
- Sponsor
- Sequana Medical N.V.
Chronic Kidney Disease
Nortriptyline and the Risk of Serious Adverse Events
This is a population-based retrospective, new-user, active comparator cohort study assessing whether initiating a new outpatient prescription of high-dose nortriptyline (>10-150 mg/day), compared with low-dose (10 mg/day), is…
- Trial name
- NCT07527481
- Testing
- Nortriptyline Hydrochloride
- Volunteers
- 5,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease, HIV Infections
Renal Function Assessment in HIV Patient
Recent progress in antiretroviral therapy has turned HIV infection into a chronic disease. Patients survival has dramatically improved but complications may occur that need to be prevented and monitored.
- Trial name
- HIVERS (NCT00821847)
- Testing
- DEXA scan
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Tumour, Advanced Solid Malignancies
A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.
This is Phase I, open-label and dose escalation study to evaluate the safety and tolerability of AZD1480(JAK2 inhibitor) in Asian patients with advanced solid tumors (Part A and C) and in patients with advanced HCC (Part B) in…
- Conditions
- Solid Tumour, Advanced Solid Malignancies, Child-Pugh A to B7 Advanced Hepatocellular Carcinoma, EGFR and/or ROS Mutant NSCLC
- Trial name
- NCT01219543
- Testing
- AZD1480 Daily, AZD1480 BID
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- AstraZeneca