Clinical trials: GI Bleeding
Hemorrhage, Trauma
RE-BLEED: A Digital Platform for Identifying Bleeding Patients - a Feasibility Study
The RE-BLEED feasibility study aims to develop and test a real-time digital platform, whereby bleeding patients in-hospital can be identified and approached for their consent to participate in future research studies.
- Conditions
- Hemorrhage, Trauma, Gastro Intestinal Bleeding
- Trial name
- RE-BLEED (NCT05608577)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
GI-bleeding
Emergency Capsule Endoscopy in Severe GI-bleeding
Primary objective: Evaluation of capsule endoscopy in the emergency setting of severe GI-Bleeding.
- Trial name
- NCT01584869
- Testing
- capsule endoscopy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
MALIGNANT GASTROINTESTINAL BLEEDING
TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL.
Introduction: Gastrointestinal (GI) bleeding arising from malignant tumors is increasingly recognized as a result of oncological advances and improved detection methods, and stems from local vessel damage and tumor invasion with…
- Trial name
- NCT02135627
- Testing
- TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery., Current standard therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage
Anticoagulation With Enhanced Gastrointestinal Safety
This study is a pragmatic cluster randomized controlled trial to evaluate the effectiveness of a clinician-facing implementation strategy on the use of medication optimization (defined as either discontinuation of all…
- Conditions
- Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage, Anticoagulant-induced Bleeding
- Trial name
- AEGIS (NCT05563714)
- Testing
- Clinician Notification with Nurse Facilitation (CNNF), Wait list control
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- University of Michigan
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Colorectal Cancer
Barriers to Care in Patients With Rectal Bleeding in Nigeria
This study sought to find the health seeking behavior of patients with rectal bleeding as related to their risk to develop colorectal cancer and also assess the general practitioner's perceived barriers to colonoscopy for…
- Trial name
- NCT02855385
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Gastric Cancer
Effects of Ilaprazole on Ulcer Healing Rate and Prevention of Gastrointestinal Bleeding in the Patients Undergone ESD.
This study compared Ulcer healing rate of Ilaprazole 20mg or Rabeprazole 20mg in the patients undergone Endoscopic Submucosal Dissection for Gastric Adenoma or Early Gastric Cancer and investigated Prevention of gastrointestinal…
- Trial name
- NCT02638584
- Testing
- Ilaprazole, Rabeprazole
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Il-Yang Pharm. Co., Ltd.
Gastrointestinal Hemorrhage, Liver Cirrhosis
Optimal Clinical Predictors to AKI in Cirrhotic Patients Experienced Acute Gastrointestinal Hemorrhage
Acute kidney injury (AKI) is a common complication, occurring in approximately 20% of hospitalized cirrhotic patients and has a significant negative impact on patients' outcomes according to either the initial stage (at the time…
- Conditions
- Gastrointestinal Hemorrhage, Liver Cirrhosis, Acute Kidney Injury
- Trial name
- ABC(AKI-B) (NCT04184934)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Von Willebrand Disease (VWD)
Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis)…
- Trial name
- WILL MANAGE (NCT06651255)
- Testing
- Optimized management, Standard of care management
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.
Gastrointestinal Bleeding
Safety Study of Octreotide Injection to Prevent GI Bleeding in Patients With Left Ventricular Assist Device (LVAD)
The investigators hypothesize that octreotide LAR (Long Acting Release) safely decreases GI bleeding in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT01707225
- Testing
- Octreotide LAR Depot
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Bleeding After GI Endoscopy
Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Tumor Bleeding: A Randomized Controlled Trial
Background Gastrointestinal bleeding is a common disease among the population in Taiwan, with gastrointestinal tumor bleeding accounting for 3-5% of cases.
- Trial name
- NCT07540026
- Testing
- 3g of sucralfate powder and 1.5g of tranexamic acid powder, Standard Treatment
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Dyspepsia, Hematemesis
Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy
The purpose of this study is to examine in prospective, double-blinded randomised manner the ability of novel articaine-containing lozenge to enhance the procedure related compliance (compared to placebo) of the adult patients…
- Conditions
- Dyspepsia, Hematemesis, Abdominal Pain, Heartburn
- Trial name
- NCT02105090
- Testing
- Anesthetics, Local, Sodium Chloride 0.9%
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Colorectal Cancer
Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
- Trial name
- NCT03032874
- Testing
- Colonoscopy
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Upper Gastrointestinal Bleeding, Gastro Intestinal Bleeding
Pediatric Acute Gastrointestinal Bleeding Registry
The goal of this study is to identify significant clinical and laboratory risk factors in pediatric patients with significant upper gastrointestinal bleeding.
- Trial name
- TRIAGE (NCT03090945)
- Testing
- This is an obsevational cohort study
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Boston Children's Hospital
Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding
Is Cap Assisted Endoscopy Useful in Acute Upper Gastrointestinal Bleeding ?
High digestive bleeding (HDH) is a medical emergency associated with high morbidity and mortality rates and significant healthcare costs. Upper endoscopy can locate the bleeding and treat it.
- Conditions
- Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding, Endoscopy
- Trial name
- CAP (NCT07268365)
- Testing
- upper endoscopy, CAP
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gastrointestinal Hemorrhage, Hematemesis; With Ulcer
Efficacy and Safety of Nexpowder™ for Non-variceal, Upper Gastrointestinal Bleeding
The purpose of this pilot clinical trial is to confirm the efficacy and safety of Nexpowder™ for hemostasis in pilot cohort of patients with NVUGIB in Singapore
- Conditions
- Gastrointestinal Hemorrhage, Hematemesis; With Ulcer, Endoscopy
- Trial name
- NCT06269588
- Testing
- Nexpowder
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- Changi General Hospital
Amorphous, Eosinophilic, and Acellular Deposit, Constipation
S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis
This phase II trial studies how well isatuximab works in treating patients with primary amyloidosis that has come back or does not respond to treatment.
- Conditions
- Amorphous, Eosinophilic, and Acellular Deposit, Constipation, Diarrhea, Early Satiety
- Trial name
- NCT03499808
- Testing
- Isatuximab, Laboratory Biomarker Analysis
- Where
- 345 sites in United States
- Volunteers
- 43 people
- Sponsor
- SWOG Cancer Research Network
Gastrointestinal Bleedings
Efficacy of Small Bowel Preparation in Capsule Endoscopy
The best preparation of small bowel is still unknown. The primary aim of this study is to evaluate the polyethylene glycol (PEG) impact of small bowel preparation for unexplained gastrointestinal bleeding exploration.
- Trial name
- PREPINTEST (NCT01267981)
- Testing
- Standard diet, Standard Diet + 500 ml of polyethyleneglycol, Standard diet + 2 liters of polyethylene glycol the day before + 500ml of polyethylene glycol
- Where
- 17 sites in France
- Volunteers
- 858 people
- Sponsor
- University Hospital, Brest
Chronic Radiation Proctitis, Rectal Bleeding
Transverse Colostomy for Refractory Hemorrhagic Chronic Radiation Proctitis: a Prospective Cohort Study
Refractory rectal bleeding of chronic radiation proctitis (CRP) is still problematic and does not respond to medical treatments including reagents, endoscopic argon plasma coagulation (APC) or topical formalin.
- Conditions
- Chronic Radiation Proctitis, Rectal Bleeding, Colostomy Stoma, Anemia
- Trial name
- NCT03397901
- Testing
- Transverse colostomy
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University