Clinical trials: GI Bleeding
GI Bleeding, Perforation Colon
Evaluation of the Clinical Utility of Endoscopic Closure Using a Dual Action Tissue (DAT) Clip
This study is designed as a multicenter prospective data recording study to document the performance of the DAT clip as part of standard medical care of patients. No experimental interventions will be performed.
- Conditions
- GI Bleeding, Perforation Colon, Perforation Bowel, Perforation Duodenal
- Trial name
- NCT05852457
- Testing
- DAT Clip
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- AdventHealth
Upper GI Bleeding
Detection of Blood in the GI Lumen With HemoPill Acute
The goal of this clinical trial is to learn if the HemoPill acute (trial device) can detect the presence of blood in participants suspected of having upper gastrointestinal bleeding.
- Trial name
- DIRECT (NCT07868068)
- Testing
- HemoPill acute
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stony Brook University
Bleeding After GI Endoscopy
Endoscopic Application of Hemostatic Drug Powder in Lower Gastrointestinal Bleeding: A Pilot Study
This clinical trial will enroll patients at National Cheng Kung University Hospital. All patients who are hospitalized for lower gastrointestinal bleeding and undergo colonoscopy will be invited to participate.
- Trial name
- NCT07679139
- Testing
- Tranexamic acid and sucralfate powder spray, Standard endsocopic hemostasis
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Risk Factors, Complication of Surgical Procedure
ACUTE-Acute Surgical Care- Risk Factors and Outcomes for Patients in Need of Acute Surgical Care
Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.
- Conditions
- Risk Factors, Complication of Surgical Procedure, Complication of Treatment, Complication of Anesthesia
- Trial name
- ACUTE (NCT05195697)
- Testing
- Observational study of different treatments and time to treatment
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Region Skane
LVAD (Left Ventricular Assist Device) Thrombosis, LVAD
STudy of Aspirin Removal in Patients Supported by the Fully Magnetically Levitated CH-VAD Pump
This multi-center, prospective, randomized, double-blinded, placebo-controlled study aims to investigate whether withdrawal of aspirin from the antithrombotic regimen in patients supported with the CH-VAD pump is non-inferior to…
- Conditions
- LVAD (Left Ventricular Assist Device) Thrombosis, LVAD, LVAD (Left Ventricular Assist Device), LVAD-related GI Bleed
- Trial name
- STAR (NCT07644247)
- Testing
- Warfarin (INR 2-3) with aspirin
- Volunteers
- 370 people
- Sponsor
- China National Center for Cardiovascular Diseases
Bleeding After GI Endoscopy
Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Tumor Bleeding: A Randomized Controlled Trial
Background Gastrointestinal bleeding is a common disease among the population in Taiwan, with gastrointestinal tumor bleeding accounting for 3-5% of cases.
- Trial name
- NCT07540026
- Testing
- 3g of sucralfate powder and 1.5g of tranexamic acid powder, Standard Treatment
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Upper GI Bleeding, Proton Pump Inhibitors
PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers
Vonoprazan (VPZ), an oral potassium-competitive acid blocker (P-CAB) has emerged as an alternative potent acid-suppressant.It has a faster onset of action in 1 day (3-5 days in PPI), and is more stable in acidic condition than…
- Trial name
- NCT05582174
- Testing
- Vonoprazan, esomeprazole
- Where
- 8 sites in China
- Volunteers
- 594 people
- Sponsor
- Chinese University of Hong Kong
Carbon Footprint in Upper GI Endoscopy, Dyspepsia
The Difference in Carbon Footprint Between Diagnostic Upper GI Endoscopy in Dyspeptic Patients Versus Therapeutic Upper GI Bleeding
The goal of this observational study is to learn about the carbon footprint produced from diagnostic upper GI endoscopy in patients with dyspepsia and therapeutic upper GI endoscopy in patients with non-variceal upper GI…
- Conditions
- Carbon Footprint in Upper GI Endoscopy, Dyspepsia, Non-variceal Upper Gastrointestinal Bleeding
- Trial name
- NCT07261228
- Where
- 2 sites in Thailand
- Volunteers
- 75 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Bleeding After GI Endoscopy
Prevention of Delayed Post-polypectomy Bleeding by Endoscopic Sucralfate Spray in High-risk Patients: A Randomized Controlled Trial
Background： Colonoscopy can detect colon polyps and perform excision to the polyps to prevent colon cancer. However, delayed polypectomy bleeding is one of the complications to be noticed, which has an occurrence rate of about…
- Trial name
- NCT07257926
- Testing
- Sucralfate, Clip
- Volunteers
- 160 people
- Sponsor
- National Cheng-Kung University Hospital
Upper GI Bleeding
Presence or Absence of Blood in the GI Lumen
Bleedings in the upper digestive tract are common. Usually, laboratory and clinical parameters are considered to establish a suspicion for a bleeding in the digestive tract and to estimate urgency of the situation.
- Trial name
- NCT05415124
- Testing
- HemoPill, Endoscopy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
GI Bleeding
Hematological Disorders in Patients With GI Angiodysplasia
The aim of this study will be to assess the association between GIT angiodysplasia with any hematological disorders as von Willebrand factor and Prognostic value of von Willebrand factor on patient's outcomes as risk of…
- Trial name
- NCT07183995
- Volunteers
- 55 people
- Sponsor
- Assiut University
GI Bleeding
High Dose Oral Omeprazole in High Risk UGIB
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding.
- Trial name
- NCT04394663
- Testing
- High-dose oral omeprazole, Standard IV PPI
- Where
- 2 sites in Thailand
- Volunteers
- 128 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Atrial Fibrillation, GI Bleeding
Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
The GI-FLX Registry is intended to create a registry of patients with a history of Atrial Fibrillation (AF) and Gastrointestinal (GI) bleed who will receive Left Atrial Appendage Closure (LAAC) with WATCHMAN FLX device and…
- Trial name
- NCT06052358
- Testing
- LAAC with Watchman FLX device
- Where
- 4 sites in United States
- Volunteers
- 73 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Bleeding After GI Endoscopy
Bleeding Rate After EGD and Colonoscopy in Patients Who Continue to Take Antithrombotic Agents
The bleeding rate of both EGD (including biopsy) and colonoscopy (including biopsy, cold or hot snare polypectomy, or EMR) in patients who continue to take various antithrombotic drugs is studied prospectively.
- Trial name
- EGD (NCT02594813)
- Testing
- Biopsy, cold or hot snare polypectomy, or EMR
- Where
- Japan
- Volunteers
- 10,000 people
- Sponsor
- Showa Inan General Hospital
Upper GI Bleeding, Point of Care Ultrasound
Bedside Ultrasonic Assessment for Gastric Content in Patients With Upper GI Bleeding Undergoing Endoscopy
Emerging studies have evaluated POCUS (Point of Care Ultrasound) for assessing of gastric content prior to anesthesia to reduce the risk of aspiration and demonstrated that POCUS can accurately identify presence of gastric food…
- Conditions
- Upper GI Bleeding, Point of Care Ultrasound, Upper Endoscopy, Gastric Content
- Trial name
- NCT05763745
- Testing
- Point of Care Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Heavy. Mentrual Bleeding, Abormal utèrine Bleeding
Effect of Tranexamic Acid and Calcium Dobesilate for Bleeding of Endometrial Origin
Abnormal uterine bleeding is characterized by excessive menstrual blood loss affecting over 50% of women of reproductive age. It can be debilitating and significantly affect a woman's quality of life.
- Conditions
- Heavy. Mentrual Bleeding, Abormal utèrine Bleeding, Bleeding, Uterine Bleeding
- Trial name
- TXA (NCT06707051)
- Testing
- Tranexamic Acid, Calcium dobesilate (Doxium)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- District Headquarters Teaching Hospital Sahiwal
Lower GI Bleeding
Safe Discharge in Lower Gastrointestinal Bleeding
The increasing incidence in lower gastrointestinal bleeding (LGIB) leads to a rise in hospital admission. Many LGBI are self-limiting thus the several scores to identify low risk patients suited to outpatient care have been…
- Trial name
- NCT06409988
- Testing
- Safe discharge
- Where
- Spain
- Volunteers
- 398 people
- Sponsor
- Germans Trias i Pujol Hospital
Upper GI Bleeding
Clinical Risk Scores in Prediction Outcome of Acute UGIT Bleeding in Non Cirrhotic Patients
To compare the ability of 4 bleeding risk scoring systems (Glasgow -Blatchford score, MAP, H3B2 and ABC scores ) in prediction of: Need of intervention, Re bleeding, Thirty-day mortality, length of hospital stay
- Trial name
- NCT06254352
- Testing
- scoring system
- Volunteers
- 100 people
- Sponsor
- Assiut University
Active Peptic Ulcer Disease/GI Bleeding
Prevention of Recurrent Ulcer Bleeding in Patients With Idiopathic Gastroduodenal Ulcer
Patients with a history of idiopathic gastroduodenal ulcer bleeding face an increased risk of recurrent ulcer gastrointestinal bleeding.
- Trial name
- NCT03675672
- Testing
- Misoprostol Oral Tablet
- Where
- Hong Kong
- Volunteers
- 154 people
- Sponsor
- Chinese University of Hong Kong
Upper GI Bleeding
Metoclopramide for Gastric Visualization in Active Upper GI Bleeding
This study aim to evaluate the efficacy of metoclopramide for gastric visualization in patients with active UGIB. This is a double-blinded, multicenter RCT.
- Trial name
- NCT06167837
- Testing
- Metoclopramide Sulfone, Normal Saline 10 mL Injection
- Where
- 2 sites in Thailand
- Volunteers
- 220 people
- Sponsor
- King Chulalongkorn Memorial Hospital