Clinical trials: GI Bleeding
Upper Gastrointestinal Bleeding
Randomized Control Trial Comparing Prokinetics and Their Influence on Endoscopy Outcomes for Upper GI Bleed.
This is a study comparing the effect of erythromycin or metoclopramide, 2 prokinetic drugs (Drugs which are known to speed up the emptying of the stomach or in other words to move the blood out of the stomach faster) given before…
- Trial name
- NCT02017379
- Testing
- Erythromycin, Metoclopromide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Malignancy, Metastasis
Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy
This proposed study is unique in that patients will not undergo computed tomography (CT) simulation at any point during their treatment course and will instead have same-session magnetic resonance (MR)-only simulation and…
- Conditions
- Malignancy, Metastasis, Hemoptysis, Gastrointestinal Bleeding
- Trial name
- MAP-RT (NCT03824366)
- Testing
- Volumetric MR imaging, Radiation therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Stress Ulcer Prophylaxis
Stress Ulcer Prophylaxis of Intravenous Esomeprazole in Chinese Seriously Ill Patients
The efficacy of esomeprazole will be compared versus cimetidine (a drug that previously demonstrated prevention of bleeding events) during treatment period in proportion of patients for the prevention of upper GI bleeding.
- Trial name
- SUP (NCT02157376)
- Testing
- Esomeprazole, Cimetidine
- Where
- 15 sites in China
- Volunteers
- 343 people
- Sponsor
- AstraZeneca
Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage
Anticoagulation With Enhanced Gastrointestinal Safety
This study is a pragmatic cluster randomized controlled trial to evaluate the effectiveness of a clinician-facing implementation strategy on the use of medication optimization (defined as either discontinuation of all…
- Conditions
- Upper Gastrointestinal Bleeding, Peptic Ulcer Hemorrhage, Anticoagulant-induced Bleeding
- Trial name
- AEGIS (NCT05563714)
- Testing
- Clinician Notification with Nurse Facilitation (CNNF), Wait list control
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- University of Michigan
Gastrointestinal Bleeding
Risk Factors for Rebleeding in Patients With Obscure Gastrointestinal Bleeding
The investigators investigated the rebleeding rate the risk factors for rebleeding after long-term follow-up (≥12 months) in patients who underwent capsule endoscopy for obscure gastrointestinal bleeding.
- Trial name
- NCT01821326
- Volunteers
- 339 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Gastrointestinal Hemorrhage
A Study to Prevent Rebleeding After Initial Successful Primary Endoscopic Haemostasis of a Bleeding Peptic Ulcer
This study is being carried out to see if constant 3 days infusion of Nexium is effective in preventing rebleeding after an endoscopic treatment.
- Trial name
- NCT00251979
- Testing
- Esomeprazole
- Where
- 78 sites in Austria, Denmark and 14 more
- Volunteers
- 1,312 people
- Sponsor
- AstraZeneca
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Melena, Gastrointestinal Hemorrhage
Comparing Early Capsule Deployment to Current Standard of Care for Management of Gastrointestinal Bleeding
The objectives of this study are to test whether there are statistically significant differences between the standard of care workup workup of non-hematemesis gastrointestinal bleeding by endoscopy [upper, lower and other tests]…
- Trial name
- EDCAP (NCT02442830)
- Testing
- Early Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Massachusetts, Worcester
Upper GI Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding With a Novel Bleeding Sensor Capsule [DING]
The clinical trial entitled "Detection of upper gastrointestinal (GI) bleeding with a novel bleeding sensor capsule - a pilot study" was carried out in a monocentric clinical trial with 30 patients.
- Trial name
- DING (NCT03176407)
- Testing
- HemoPill acute
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ovesco Endoscopy AG
Gastrointestinal Bleeding
Safety Study of Octreotide Injection to Prevent GI Bleeding in Patients With Left Ventricular Assist Device (LVAD)
The investigators hypothesize that octreotide LAR (Long Acting Release) safely decreases GI bleeding in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT01707225
- Testing
- Octreotide LAR Depot
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Bleeding Peptic Ulcer
Argon Plasma Coagulation vs Hemoclipping for Bleeding Peptic Ulcers
Endoscopic treatment is recommended for initial hemostasis in nonvariceal upper gastrointestinal bleeding. However, the additional hemostatic efficacy of argon plasma coagulation (APC) has not been widely investigated.
- Trial name
- NCT04366583
- Testing
- argon plasma coagulation, hemoclipping
- Where
- Taiwan
- Volunteers
- 166 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Gastrointestinal Hemorrhage
Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance
The purpose of this research study is to measure the effect on of a large language model interface on the usability, attitudes, and provider trust when using a machine learning algorithm-based clinical decision support system in…
- Trial name
- NCT05816473
- Testing
- LLM
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Heart Failure, Gastrointestinal Bleeding
Efficacy of Omega-3 Fatty Acid Therapy in Preventing Gastrointestinal Bleeding in Patients With CF-LVAD
This study evaluates the efficacy of high-dose fish oil in decreasing rates of gastrointestinal bleeding in patients with continuous-flow left ventricular assist devices.
- Trial name
- NCT03784963
- Testing
- Omega 3 fatty acids
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Chicago
Obscure Gastrointestinal Bleeding, Angiodysplasia
Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation
Background: Repeated episodes of bleeding from gastrointestinal vascular malformations refractory to endoscopic or surgical therapy often pose a major therapeutic challenge.
- Conditions
- Obscure Gastrointestinal Bleeding, Angiodysplasia, Gastric Antral Vascular Ectasia, Thalidomide
- Trial name
- NCT00964496
- Testing
- Thalidomide, Iron
- Volunteers
- 55 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pelvic Neoplasms
Treatment of Hemorrhagic Radiation Proctitis Using the Halo System
This study involves evaluating a procedure in which the study device, the HALO90 Ablation catheter, is used to heat a thin layer of tissue lining the rectum using radiofrequency (RF) energy in subjects suffering from radiation…
- Trial name
- NCT01103492
- Testing
- HALO90 Ablation catheter
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Bleeding Peptic Ulcer
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
To describe the rate of clinically significant rebleeding during 72 hours continuous i.v. infusion of high dose esomeprazole Na in patients in China with primary successful endoscopic haemostatic therapy of a bleeding peptic…
- Trial name
- NCT01757275
- Testing
- Esomeprazole Na, Cimetidine, Esomeprazole Mg
- Where
- 12 sites in China
- Volunteers
- 239 people
- Sponsor
- AstraZeneca
Peptic Ulcer Hemorrhage
Effect of High-dose Oral Rabeprazole on Recurrent Bleeding After the Endoscopic Treatment of Bleeding Peptic Ulcers
This study is conducted to compare and evaluate the effect of administering a high-dose intravenous proton pump inhibitors or high-dose oral Rabeprazole in preventing recurrent bleeding after the endoscopic treatment of bleeding…
- Trial name
- NCT00838682
- Testing
- omeprazole sodium IV, Rabeprazole
- Where
- 2 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- The Catholic University of Korea
UGI Bleeding, Ulcer or Variceal Hemorrhage
Doppler Ultrasound Probe for Blood Flow Detection in Severe Upper Gastrointestinal Hemorrhage
The main purposes of this study are to compare clinical outcomes of two groups of patients with similar medical conditions (one with non-variceal upper gastrointestinal (UGI) lesions such as ulcers and another group with varices…
- Conditions
- UGI Bleeding, Ulcer or Variceal Hemorrhage, Stigmata of Recent Hemorrhage, Endoscopy
- Trial name
- NCT00732212
- Testing
- Doppler endoscopic ultrasound probe for blood flow detection, Standard endoscopic hemostasis
- Where
- 2 sites in United States
- Volunteers
- 235 people
- Sponsor
- VA Office of Research and Development
Amorphous, Eosinophilic, and Acellular Deposit, Constipation
S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis
This phase II trial studies how well isatuximab works in treating patients with primary amyloidosis that has come back or does not respond to treatment.
- Conditions
- Amorphous, Eosinophilic, and Acellular Deposit, Constipation, Diarrhea, Early Satiety
- Trial name
- NCT03499808
- Testing
- Isatuximab, Laboratory Biomarker Analysis
- Where
- 345 sites in United States
- Volunteers
- 43 people
- Sponsor
- SWOG Cancer Research Network
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina