Clinical trials: GI Disorders
Gastroenteritis
Bivalent Norovirus Vaccine Study
Randomized, multi-site, dose-escalation study of the safety and immunogenicity of four dosage levels of Intramuscular (IM) Norovirus Bivalent VLP Vaccine adjuvanted with MPL and Al(OH)3 compared to controls.
- Trial name
- NCT01168401
- Testing
- NoV GI.1/GII.4 Bivalent VLP Vaccine, Saline
- Where
- 3 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Takeda
Delayed Gastric Emptying
Reference Values for Gastric Emptying
Healthy volunteers will ingest a 13C-octaoate containing test meal and 13C in expiratory air will be followed. Normal values will be calculated data of these tests.
- Trial name
- 13C (NCT02397577)
- Testing
- Solid test meal, liquid test meal on two separate occations
- Where
- Switzerland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Colorectal (Colon or Rectal) Cancer
Endoscopic Submucosal Dissection of Large Recto-sigmoid Lesions Under Spinal Anesthesia
The investigators collected data on all consecutive patients who underwent ESD for recto-sigmoid laterally spreading tumors (LSTs) >35 mm under SA between January 2021 and March 2024.
- Trial name
- NCT06316401
- Testing
- ESD of large LSTs under SA
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Azienda USL Modena
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Short Gut Syndrome
Successful Fiber Food Introduction in Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.
- Trial name
- GREENBEANS (NCT06240065)
- Testing
- Green bean puree
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Colitis Ulcerosa, Colitis Ulcerative
Magnesium in Gastrointestinal Disease
Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency.
- Conditions
- Colitis Ulcerosa, Colitis Ulcerative, Crohns Disease, Morbus Crohn
- Trial name
- MAGIC (NCT07338565)
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Barrett's Esophagus
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System
The goal of this research is to test a distal scanning capsule and a compact redesigned version of the OFDI imaging system in healthy and BE participants to assess ease of use, safety and feasibility in preparation for its use in…
- Trial name
- NCT02947971
- Testing
- Experimental OFDI Imaging
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Celiac Disease in Children, Celiac Disease in Adolescents
Effect of Adherence to a Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease
The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac…
- Trial name
- NCT07382999
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Inonu University
Colorectal Neoplasms
A 4-arm Clinical Trial of Fuse®, EndoCuff™, EndoRings™ and Standard Colonoscopy
Adenoma detection rate (ADR) is a validated marker for reducing the risk of interval colorectal cancer after a screening colonoscopy.
- Trial name
- NCT02345889
- Testing
- Colonoscopy with EndoCuff™, FUSE® Colonoscopy, Colonoscopy with EndoRings™
- Where
- United States
- Volunteers
- 1,262 people, healthy volunteers welcome
- Sponsor
- Indiana University
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Crohn Disease, Ulcerative Colitis
Inflammatory Bowel Diseases (IBD) Cannabis Registry
The inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), are characterized by lifelong relapsing-remitting gastrointestinal inflammation, with symptoms of abdominal pain, diarrhea, and rectal…
- Conditions
- Crohn Disease, Ulcerative Colitis, Pouchitis, Healthy
- Trial name
- IBD (NCT05578313)
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Eli Sprecher, MD
Dysphagia, Oropharyngeal
The Efficacy of Tongue Exercises on Swallowing Function in the Elderly With Mild Cognitive Impairment
The purpose of this study is to explore the effects of tongue muscle strength and resistance exercises on dysphagia, tongue muscle strength, oral hygiene, repetitive saliva swallowing, nutrition, depression, and…
- Trial name
- NCT06490705
- Testing
- tongue resistance exercises, tongue strengthening exercises and tongue resistance exercises
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Breast Cancer, Colorectal Cancer
Effect of Kefir on Symptom Management and Quality of Life in Oncology
This study was planned as a randomized controlled prospective experimental study to determine the effect of kefir on symptom management and quality of life in oncology patients receiving chemotherapy.
- Trial name
- NCT06517420
- Testing
- kefir consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Healthy, Colorectal Adenoma
IMPACT OF SEDENTARY BEHAVIOR IN THE HOMEOSTASIS OF THE DIGESTIVE ECOSYSTEM
This study seeks to determine the relationship between sedentary behavior, gut transit, gut microbiota and polyps development. Will be conducted an evaluation which includes assessments of physical activity behaviors (through…
- Trial name
- NCT07398820
- Testing
- Initial assessment
- Where
- Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Clínica Universidad de los Andes
Colorectal Cancer, Tumor
Microbiome in Colorectal Cancer Onset and Progression
This is an observational study with the goal to improve the robustness of the scientific evidence linking Fusobacterium nucleatum (Fn) and/or other microorganisms to colorectal cancer (CRC) onset and/or progression.
- Conditions
- Colorectal Cancer, Tumor, CRC, GI Cancer
- Trial name
- NCT05368688
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Viome
Laryngopharyngeal Reflux, Gastro Esophageal Reflux
LPR Fluorescence Pilot
Comparing the fluorescence signatures from mouthwash samples of patients with laryngopharyngeal reflux (LPR) and healthy volunteers.
- Trial name
- NCT05204303
- Testing
- 24-hour pH-impedance monitoring, Symptom questionnaires, ROME IV Diagnostic Questionnaire
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
Pelvic Cancer, Enteritis, Probiotics,Chemoradiotherapy
Oral Probiotics on Radiation Enteritis Stage Ⅱ Induced by Pelvic Concurrent Chemoradiotherapy
Effect of Probiotics on Raditon Enteritis in Pelvic Tumor Patients Receiving Radiotherapy.
- Trial name
- probiotics (NCT05032027)
- Testing
- probiotics
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jiangxi Provincial Cancer Hospital
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