Clinical trials: GI Disorders
Gastroenteritis
Evaluation of Recombinant Norovirus Hexavalent Vaccine in Healthy Subjects
To evaluate the safety and immunogenicity of different dose levels of the Recombinant Norovirus Hexavalent Vaccine in healthy subjects aged 18-59 years given three doses of the vaccine at 28-day intervals.
- Trial name
- NCT05805618
- Testing
- Recombinant Norovirus Hexavalent Vaccine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Syneos Health
Eosinophilic Esophagitis, Barrett Esophagus
Imaging of the Esophagus Using a SECM Capsule
The goal of this validation study is to compare Spectrally Encoded Confocal Microscopy (SECM) Tethered Capsule Endoscopy (TCE) diagnosis of Eosinophilic Esophagitis to that of standard of care endoscopic biopsy.
- Trial name
- NCT03546660
- Testing
- SECM capsule
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer
A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)
This study will collect biospecimens (including blood, tissue, and stool samples) and health information to create a database-a type of collection of information-for better understanding young onset colorectal cancer (YOCRC).
- Trial name
- NCT05568420
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Liver Metastases
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer
This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or…
- Trial name
- HITM-SURE (NCT02850536)
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Roger Williams Medical Center
Pregnancy Related
Diagnostic Performance of Antenatal Ultrasound for High-Risk Intestinal Malrotation
The aims of this study are: To assess the performance of third-trimester ultrasound scan in the localization of intestinal structures (small bowel, gut, mesenteric vessels..) involved in malrotations with a higher-risk of…
- Trial name
- MALGRE (NCT03968107)
- Testing
- Reference ultrasound examination
- Where
- France
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Colorectal Cancer
Dissemination of Colorectal Cancer Screening to Primary Care Physicians
The aim is to assess the efficacy of an intervention, academic detailing, a brief, frequently repeated educational program, on increasing recommendations for colorectal cancer screening among primary care providers by comparison…
- Trial name
- NCT00441311
- Testing
- Academic Detailing
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Columbia University
Deglutition Disorders
Establishment of Voice Analysis Cohort for Development of Monitoring Technology for Dysphagia
Collection of basic data to develop a technique for monitoring the state of dysphagia using voice analysis.
- Trial name
- NCT05149976
- Testing
- Voice recording before and after dietary intake
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Adults
Localized Therapeutics for the Treatment of Gastrointestinal Disorders
The purpose of this study is to determine the patient preference for a biocompatible thermosensitive solution-gel versus water or saline (liquid) enema.
- Trial name
- NCT02290665
- Testing
- Thermosensitive gel rectal formulation, Saline enema
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Stanford University
Gastroparesis
Antro-pyloro-duodenal Motility in Idiopathic Gastroparesis
Impaired gastric emptying may cause dyspeptic symptoms including nausea, vomiting and even nutritionnal impairment. Delay in gastric emptying may result from antro-pyloro-duodenal motility impairement.
- Trial name
- NCT01519180
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Gastro Esophageal Reflux
Esophageal and Gastric Registry and Biorepository
The evaluation of the foregut, the esophagus and stomach, has come a long way over the past two decades, and continues to experience exciting discoveries in the clinical evaluation of foregut physiology.
- Trial name
- NCT05180253
- Testing
- Esophageal studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Colorectal Carcinoma
Online Mindfulness-Based Intervention to Decrease Pre-Procedural Anxiety Before a First-Time Screening Colonoscopy
This clinical trial tests how well an online mindfulness-based intervention (MBI) works to decrease anxiety in patients before a first-time screening colonoscopy.
- Trial name
- NCT06233253
- Testing
- Best Practice, Medical Chart Review, Online Mindfulness Meditation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Dysphagia
Motor Imagery Exercise and Tongue Strength
This research study is a six-week treatment pilot study to compare the effects of different exercise types on measures of tongue strength and swallowing pressure in typically aging older adults.
- Trial name
- NCT03423095
- Testing
- Active Jaw Exercise with Relaxation, Active Tongue Exercise, Active Tongue Exercise + Mental Practice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Milk Intolerance
Effects of A2 Milk on Gastrointestinal Function in Non-lactose Milk Intolerance
There is increasing evidence that a number of people experience moderate milk intolerance characterised by increased gas production, bloating and abdominal cramp, which can neither be attributed to lactose intolerance, nor to…
- Trial name
- NCT03060395
- Testing
- A2 milk 100, A2 milk 150, A2 milk 200
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Reading
Pancreaticoduodenectomy, Pancreatic Fistula
Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes
Pancreaticoduodenectomy (PD), more commonly known as Whipple's surgery is the mainstay treatment for pancreatic head and periampullary cancer.
- Conditions
- Pancreaticoduodenectomy, Pancreatic Fistula, Delayed Gastric Emptying, Pancreatic Cancer
- Trial name
- NCT04418739
- Testing
- Human albumin
- Where
- Malaysia
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Necrotising Enterocolitis
The Efficacy of Symbiotic on Cytokines
The aim of this prospective double blinded randomised study is to investigate the efficacy of symbiotic preparation which contains lactobacillus casei, L. rhamnosus, L.
- Trial name
- NCT01899677
- Testing
- distilled water, symbiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Hemorrhoids
EnSeal Device Versus Ferguson Technique in Hemorrhoidectomy
This study will compare hemorrhoid surgery by comparing a sutureless heating device with the old standard hemorrhoid surgery. Patients will be followed closely for wound healing and satisfaction.
- Trial name
- NCT00853853
- Testing
- EnSeal Device, Ferguson Hemorrhoidectomy technique
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Steven Schechter, M.D.
Hirschsprung Disease
Hirschsprung Disease Genetic Study
Hirschsprung disease is a genetic condition caused by lack of nerve cells in varying lengths of the intestines. This study will investigate the complex genetic basis of the disease, which involves multiple interacting genetic…
- Trial name
- NCT00478712
- Testing
- Identification of genetic causes of Hirschsprung Disease
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Dysentery, Shigellosis
Efficacy, Immunogenicity and Safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in Volunteers Aged From 6 Months to 5 Years
The purpose of this study is to evaluate the efficacy, immunogenicity and safety of S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine in infants and children aged from 6 months to 5 years.
- Trial name
- NCT05156528
- Testing
- S. Flexneriza-S. Sonnei Bivalent Conjugate Vaccine
- Where
- 9 sites in China
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Constipation, Children
Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children
Pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum.
- Conditions
- Constipation, Children, Fecal Incontinence
- Trial name
- NCT02812823
- Testing
- High-resolution anorectal manometry
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Colorectal Cancer Screening, Hepatitis C Virus
Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening
This innovative Multilevel Action Toward Colorectal Cancer (CRC) and Hepatitis C Virus (HCV) Education and Screening (MATCHES) intervention aims to promote concurrent HCV and CRC screening among FQHC patients ages 45-75.
- Trial name
- MATCHES (NCT06745895)
- Testing
- MATCHES
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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