Clinical trials: GI Disorders
Colorectal Cancer, Colorectal Carcinoma
Increasing Access to Colorectal Cancer Testing (IACCT) for Blacks
The purpose of this research study is to compare a new educational material to another widely available educational brochure. The goal is to see if the new educational material will change knowledge and behaviors about colorectal…
- Trial name
- IACCT (NCT03078348)
- Testing
- Fecal Immunochemical Test (FIT) Kit, Culturally targeted Photo Novella Booklet, Screen for Life Brochure
- Where
- United States
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Stomach Neoplasm
Exploring the Difference Between Gastric Cardia Cancer and Non-cardia Gastric Cancer Based on Multiomics
This is an observational study with a case control design. This study included patients with gastric cancer confirmed by pathological diagnosis of gastric tissue, and matched the control population according to age, gender, etc.
- Trial name
- NCT05812287
- Testing
- Detection of biological samples based on multi-omics analysis
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Fibromyalgia, Irritable Bowel Syndrome
Welfare Benefits in Functional Somatic Disorders
The objective of this observational study is to estimate the number of weeks of welfare benefits, i.e. sickness benefit, unemployment benefit and social assistance, for individuals with functional somatic disorders and compare…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome, Bodily Distress Syndrome
- Trial name
- NCT05611606
- Volunteers
- 9,656 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Colorectal Cancer
Establishment and Clinical Validation of New Technologies for Accurate Screening of Colorectal Cancer Based on Multi-omics
Background: The current screening techniques for colorectal cancer include colonoscopy, fecal occult blood, and high-risk factor questionnaires.
- Trial name
- NCT04913233
- Where
- 3 sites in China
- Volunteers
- 9,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bladder Cancer, Glioma
Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With Cancer
The objective of this study is to assess two novel positron emission tomography (PET) radiotracers, [64Cu]CM500 and [68Ga]CM500, for Positron Emission Tomography-Magnetic Resonance Imaging (PET-MR) and Positron Emission…
- Conditions
- Bladder Cancer, Glioma, Glioblastoma (GBM), Breast Cancer
- Trial name
- NCT07781852
- Testing
- [64Cu]CM500, [68Ga]CM500, PET/MR
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lumina Pharmaceuticals Inc
Colorectal Neoplasms, Colorectal Cancer
Bile Acids and Microbiome in Early Colorectal Carcinogenesis
Currently colorectal cancer pathogenesis is mainly explained by the adenoma-carcinoma sequence theory that was proposed more than half a century ago.
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Colorectal Polyp, Microbiome
- Trial name
- NCT06502704
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Colorectal Cancer
Evaluation of a Point-of-care Testing Instrument for Fecal Immunochemical Test
Early detecting and removing of colorectal advanced adenomas can reduce incidence of colorectal cancer.Use of the fecal immunochemical test (FIT) for colorectal cancer (CRC) prevention is supported by previous studies.However…
- Trial name
- NCT05232721
- Testing
- The new instrument and colonoscopy with pathological examination
- Where
- China
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Shandong University
Compassion, Perfectionism
An Online Compassionate Imagery Intervention for Veterinarian Mental Health
This randomised control trial aims to determine the efficacy of a two-week, online compassionate imagery intervention on improving veterinarian mental wellbeing.
- Conditions
- Compassion, Perfectionism, Rumination, Self-Criticism
- Trial name
- NCT05589116
- Testing
- Online Compassionate Imagery Intervention
- Where
- United Kingdom
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Rumination, Depression
Adolescent Mindfulness Mobile App Study (RCT)
Rumination involves focusing on negative emotions repeatedly and is a risk factor for developing depression, anxiety, and self-injury. These negative outcomes increase in adolescence.
- Conditions
- Rumination, Depression, Anxiety, Self-Injurious Behavior
- Trial name
- AMMASRCT (NCT03900416)
- Testing
- Mindfulness App
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Colorectal Cancer
Early Diagnosis and Recurrence Monitoring of Colorectal Cancer
Colorectal cancer (CRC) has an insidious onset and its survival rate is closely related to clinical stage. While the 5-year survival rate of stage I patients exceeds 90%, it drops to 14% in stage IV.
- Trial name
- NCT06991452
- Testing
- Liquid biopsy
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Gastric Cancer
Novel Screening Modality for Early Gastric Cancer
Potential patients will be recruited at participating sites based on routine care with clinical indications for upper endoscopy.
- Trial name
- NCT04114006
- Where
- Honduras
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gastrointestinal Stromal Tumors, Renal Cell Carcinoma
A Bioequivalence Study of Sunitinib Malate Capsules.
A randomized, open, two-period, two-sequence crossover trial design used to assess the pharmacokinetics and safety of Sunitinib Malate Capsules in healthy volunteers under fed condition, and compare the bioequivalence of…
- Conditions
- Gastrointestinal Stromal Tumors, Renal Cell Carcinoma, Pancreatic Neuroendocrine Tumor
- Trial name
- NCT05800106
- Testing
- Sunitinib malate capsules generic product, Sunitinib malate capsules reference product
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Lynch Syndrome, Neoplasms
The GEOLynch Cohort Study
The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
- Conditions
- Lynch Syndrome, Neoplasms, Hereditary Nonpolyposis Colorectal Cancer, Colorectal Neoplasms
- Trial name
- GEOLynch (NCT03303833)
- Testing
- No intervention, observational study.
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Irritable Bowel Syndrome
Effect of MethylceIlulose or Psyllium on Fermentation of Inulin Assessed Using a Gas Sensing Capsule
The investigators plan to measure the local (in vivo) production of hydrogen when methylcellulose is ingested, to see if the investigators can show a shift of the site of fermentation to the distal colon.
- Trial name
- REALISTIC (NCT06551948)
- Testing
- psyllium, methylcellulose, maltodextrin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Food Habits, Energy Metabolism
Environmental Factors and the Gut Microbiome - Endocannabinoid Axis
The general objective of this project is to investigate the interplay of the gut microbiome - endocannabinoid axis with host environmental factors and intestinal, metabolic and mental health status in free-living adults with…
- Conditions
- Food Habits, Energy Metabolism, Mental Health Wellness 1, Intestinal Disease
- Trial name
- eMECA (NCT03463304)
- Where
- Canada
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Laval University
Inflammatory Bowel Diseases
AIRE-2 Device for Study of Breath Analysis in IBD
The goal of this Prospective single-blinded intervention feasibility study is the utilization of the AIRE-2 device and FoodMarble app to elucidate the interplay among diet, symptoms, and microbial fermentable features in IBD…
- Trial name
- AIRE-2 (NCT06541938)
- Testing
- low FODMAP diet, Lactose Sachet, Fructose Sachet
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Colorectal Cancer, Prevention
A Cross-sectional Partnership to Improve Prevention and Health Equity Among African Americans
African Americans face racial disparities in colorectal cancer (CRC), with lower screening rates and higher incidence and mortality rates.
- Trial name
- NCT05903885
- Testing
- On-site Fecal Immunochemical Test (FIT) Kit Distribution, On-site With Social Media Advertising Fecal Immunochemical Test (FIT) Kit Distribution
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dental Implant
The Effectiveness of Single Tufted Brush in the Management of Peri-implant Mucositis
The study aims to investigate and compare the reduction in (1) soft tissue inflammation and (2) amount of plaque accumulation at implant sites with (test) or without (control) patient administered use of single tufted brush.
- Trial name
- NCT03872687
- Testing
- single tufted brush with IDB, interdental brushes
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National University Health System, Singapore
IBD, Crohns Disease
IBDSL Biobank Project. Molecular Markers for Diagnosis and Therapy Response in IBD.
The IBD South Limburg (IBDSL) project was initially designed as a prospective population based cohort study. Since 1991, all new IBD cases have been enrolled in the cohort and prospectively followed.
- Conditions
- IBD, Crohns Disease, Ulcerative Colitis
- Trial name
- IBDSL (NCT02130349)
- Where
- 3 sites in Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Metastatic Colorectal Cancer
Couple-Based Mindfulness Intervention for Metastatic Colorectal Cancer
The overall objective of this study is to develop a novel couple-based mindfulness intervention aimed at reducing distress in patients with metastatic colorectal cancer (mCRC) and their partners.
- Trial name
- NCT05840263
- Testing
- Qualitative interview, Cognitive Interviews
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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