Clinical trials: GI Disorders
Appendicitis
Open Versus Laparoscopic Appendectomy
The aim of this prospective randomized trial is to compare the feasibility of open with laparoscopic appendectomy in suspected acute appendicitis.
- Trial name
- NCT00908804
- Testing
- open appendectomy, laparoscopic appendectomy
- Where
- Finland
- Sponsor
- North Karelia Central Hospital
Colorectal Cancer, Colorectal Neoplasm
A Stool DNA Test for Detection of Advanced Colorectal Neoplasia in Asymptomatic Chinese Community Population
to determine screening value of stool-based SDC2 DNA methylation test for advanced colorectal neoplasia in the asymptomatic Chinese community population.
- Conditions
- Colorectal Cancer, Colorectal Neoplasm, Advanced Adenoma, Adenoma
- Trial name
- NCT04786704
- Testing
- Stool-based SDC2 DNA methylation test, quantitative Fecal immunochemical test
- Where
- China
- Volunteers
- 12,106 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Post-induction Hypotension, Intestinal Obstruction
SV and IVC Collapsibility Index to Predict Postinduction Hypotension
Postinduction hypotension (PIH) is a frequent complication during general anesthesia. This study aims to compare the predictive effectiveness and diagnostic accuracy of stroke volume (SV) measured via left ventricular outflow…
- Trial name
- NCT07742904
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Esophageal Cancer, Gastroesophageal Junction Cancer
Study of Porcine Fibrin Sealant in Preventing Cervical Anastomotic Leakage for Esophageal or Junctional Carcinoma.
The primary objective is to evaluate the efficacy and assess the role of Porcine Fibrin Sealant (Bioseal®) in preventing cervical anastomotic leakage after esophagectomy in the patients with resectable thoracic esophageal cancer…
- Conditions
- Esophageal Cancer, Gastroesophageal Junction Cancer, Anastomotic Leak
- Trial name
- PLACE020 (NCT03529266)
- Testing
- Porcine Fibrin Sealant (PFS), Surgery
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Sun Yat-sen University
Barrett Esophagus, Esophageal Adenocarcinoma
Obeticholic Acid for Prevention in Barrett's Esophagus
This phase II trial studies the effect of obeticholic acid in treating patients with Barrett's esophagus. Bile acids present in duodenogastroesophageal reflux contribute to neoplastic progression in Barrett's esophagus.
- Trial name
- NCT04939051
- Testing
- Biospecimen Collection, Esophageal Biopsy, Esophagogastroduodenoscopy
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Colorectal Cancer
Safety Study of Transumbilical Single Incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
Compared with traditional open colectomy, laparoscopic surgery is associated with less pain, earlier recovery, and better cosmetic outcome, and its short- and long-term oncologic outcomes have been demonstrated.
- Trial name
- NCT02117557
- Testing
- Single incision laparoscopic surgery, Conventional laparoscopic surgery
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Guoxin Li
Adenocarcinoma of the Gastroesophageal Junction, Diffuse Gastric Adenocarcinoma
Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer
This phase II clinical trial studies how well Akt inhibitor MK2206 works in treating patients with advanced gastric or gastroesophageal junction cancer.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Diffuse Gastric Adenocarcinoma, Gastric Intestinal Type Adenocarcinoma, Gastric Mixed Adenocarcinoma
- Trial name
- NCT01260701
- Testing
- Akt Inhibitor MK2206
- Where
- 187 sites in United States, Canada
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute (NCI)
Crohn's Disease
Nutritional Therapy Study in Pediatric Crohn's Disease
The investigators are doing this research study to answer questions about a nutritional therapy called the Specific Carbohydrate Diet (SCD) for children with active Crohn's Disease (CD).
- Trial name
- NCT02610101
- Testing
- Traditional SCD Diet, Modified SCD Diet, Whole foods diet
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Seattle Children's Hospital
Colorectal Cancer, Functional Status
Functional and Respiratory Predictors of Early Postoperative Outcomes
Functional status is a fundamental indicator reflecting a patient's ability to perform activities of daily living and is closely associated with early postoperative outcomes.
- Conditions
- Colorectal Cancer, Functional Status, Respiratory Parameters, Clinical Outcomes
- Trial name
- NCT07529301
- Testing
- Preoperative Assessments, Postoperative Assessments (Daily from Postoperative Day 1 Until Discharge)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Müşerref Ebru YALÇIN
Crohn's Disease
CD INFORM: Investigating Natalizumab Through Further Observational Research and Monitoring
The primary objective of the study is to determine the incidence and pattern of serious and/or clinically significant infections, malignancies, and other serious adverse event (SAE) in participants with Crohn's Disease (CD)…
- Trial name
- INFORM (NCT00707512)
- Testing
- natalizumab
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 87 people
- Sponsor
- Biogen
Inflammatory Bowel Disease
Fecal Transplantation for Inflammatory Bowel Disease
Fecal microbial treatment (FMT) is a treatment that utilizes the microbiota of a healthy intestine as a probiotic preparation. The feces of a healthy individual is fluidized and than inserted into the intestinal tract of a sick…
- Trial name
- FMT IBD (NCT02391012)
- Testing
- Fecal microbial l transplantation
- Where
- 2 sites in Israel
- Volunteers
- 9 people
- Sponsor
- Meir Medical Center
Inflammatory Bowel Diseases
Folic Acid in Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease often requires immunomodulators, such as methotrexate, to maintain disease remission. This medication is administered as one dose weekly.
- Trial name
- NCT03860012
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital
Hemorrhoids, Haemorrhoids
Effect of Early Warm Water Sitz Bath on Urinary Retention After Hemorrhoidectomy
Background: Hemorrhoid is one of the most common chronic anorectal diseases. The prevalence rate is about 44%. It occurs in adults aged 45-65 years.
- Conditions
- Hemorrhoids, Haemorrhoids, Piles, Hemorrhoidal Disease
- Trial name
- NCT04535765
- Testing
- early warm water sitz bath, Regular time warm water sitz bath
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Cathay General Hospital
Swallowing Disorder
Swallowing Difficult Sensation After Cervical Spine Surgery
In many cases, the manometric examination is not feasible because of the pharyngeal sinusitis or pharyngeal torsion. In addition, although previous conventional manometry was used to estimate pharyngeal swallowing, the bolus flow…
- Trial name
- NCT04591665
- Testing
- swallowing examination
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- National Taiwan University Hospital
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Rectal Cancer
Chinese Surgical Robot Clinical Study on Rectectomy for Rectal Cancer
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Trial name
- NCT04836741
- Testing
- Micro Hand S robot, Laparoscope
- Where
- China
- Volunteers
- 105 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Selected Advanced Solid Tumors, Colorectal Cancer (CRC)
SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors
This Phase 1, open-label study will evaluate two investigational radiopharmaceuticals in adults with selected advanced or metastatic solid tumors.
- Conditions
- Selected Advanced Solid Tumors, Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Biliary Tract Cancer (BTC)
- Trial name
- NCT07812805
- Testing
- SKL35501, SKL35502
- Where
- 5 sites in United States, South Korea
- Volunteers
- 100 people
- Sponsor
- SK Life Science, Inc.
Metastatic Colorectal Cancer
Study to Evaluate the Safety, Tolerability and Efficacy of FOLFOX + CT-011 Versus FOLFOX Alone
This clinical trial will be performed in previously untreated patients with metastatic colorectal cancer. The study will evaluate the safety, tolerability and efficacy of the study drug, CT-011, in combination with FOLFOX…
- Trial name
- NCT00890305
- Testing
- CT-011, FOLFOX
- Where
- 31 sites in United States, Bulgaria and 4 more
- Volunteers
- 171 people
- Sponsor
- Medivation, Inc.
Metastatic Colorectal Cancer
Prospective Translational Study Investigating Molecular Predictors of Resistance and Response to Regorafenib Monotherapy
This is a single centre prospective biological translational research study involving the collection of tumour tissue, blood samples and clinical data from patients being treated with regorafenib for metastatic Colorectal Cancer…
- Trial name
- PROSPECT-R (NCT03010722)
- Testing
- Regorafenib
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- Royal Marsden NHS Foundation Trust
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