Clinical trials: GI Symptoms
Functional Constipation
Dose-Responsive Effect of Polydextrose on Whole Gut Transit Time
The aim of the study is to test the effect of polydextrose on whole gut transit time and gastrointestinal symptoms in a dose-responsive manner.
- Trial name
- PDX-Transit (NCT01540669)
- Testing
- Polydextrose, low dose, Polydextrose, medium dose, Polydextrose, high dose
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Danisco
Antibiotic-associated Diarrhea
The Efficacy of a Probiotic for Antibiotic Associated Gastrointestinal Symptoms
This study evaluates the effect of a multistrain probiotic on gastrointestinal (GI) complaints and diarrhoea in subjects receiving short-term antibiotic (AB) treatment
- Trial name
- PANDA (NCT05845073)
- Testing
- Probiotic
- Where
- Germany
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Irritable Bowel Syndrome (IBS)
The Role That Food and Bacteria Play in Generating Abdominal Pain
Irritable Bowel Syndrom (IBS) affects up to five percent of Canadians and has proven difficult to treat. Our research will explore how a type of dietary carbohydrate, called FODMAPS, contributes to chronic abdominal pain in…
- Trial name
- NCT07688044
- Testing
- FODMAP Challenge
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- David Reed
ASD Accompanied by Moderate to Severe Gastrointestinal Symptoms
Explore Efficacy of FMT Treating Childhood ASD Patients
To explore the efficacy of fecal microbiota transplantation (FMT) in improving the gastrointestinal symptoms and autism symptoms in patients diagnosed as autism spectrum disorder (ASD) comorbid with gastrointestinal symptoms.
- Trial name
- NCT04142255
- Testing
- FMT
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Gastrointestinal Hemorrhage, Volatile Organic Compounds
Volatile Organic Compounds (VOCs) of Exhaled Breath in Patients With GI Bleeding
Cross sectional case-control study investigating the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population.
- Trial name
- NCT04226079
- Testing
- Collection of exhaled breath
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Gastroesophageal Reflux, Heartburn
HEARD (Long Term) Study - Histology of the Esophagus in Acid-Related Disease
Determine if different levels of acid-suppression with esomeprazole for 6 months on chosen histological markers of esophageal epithelial acid-related disease in patients with upper GI symptoms.
- Conditions
- Gastroesophageal Reflux, Heartburn, Dyspepsia
- Trial name
- NCT00243724
- Testing
- Esomeprazole
- Where
- 10 sites in Canada
- Volunteers
- 350 people
- Sponsor
- AstraZeneca
Healthy Adult Females, Gastrointestinal Symptoms
The Effect of Daily Supplementation With Humiome® Post LB on Gastrointestinal Symptoms in Female Athletes
Female athletes are often overlooked in scientific research, including the understanding of their digestive system and its impact on overall health, training, and performance.
- Trial name
- GI-Jane (NCT07366931)
- Testing
- Postbiotic
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Recurrent Gastrointestinal Bleeding
Computed Tomography Enterography (CTE) Versus Capsule Endoscopy for Overt, Obscure Gastrointestinal (GI) Bleeding
Up to 5% of patients with recurrent gastrointestinal (GI) bleeding remain undiagnosed by upper endoscopy and colonoscopy, the presumed source of bleeding in these patients being the small intestine.
- Trial name
- NCT01114295
- Testing
- Capsule Endoscopy, CT Enterography
- Sponsor
- Brigham and Women's Hospital
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Incremental Doses of a Sugar Replacer Blend on Gastrointestinal Tolerance in Chocolate
This study is a randomized, double-blind, crossover trial aiming at evaluating the gastrointestinal tolerance of sugar replacer ingredients and blends (maltitol, kestose (Oligofructose), kestose + cocoa and polydextrose premix at…
- Trial name
- NCT06479330
- Testing
- Milk Chocolate
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Gastroesophageal Reflux Disease
Efficacy of Pantoprazole 20/40 mg Once Daily (od) in Patients Older Than 12 Years Who Have Gastrointestinal Symptoms of Reflux Disease
The aim of this study was to evaluate the effect of 14 days treatment with Pantoprazole 40 mg and 20 mg on gastroesophageal reflux disease (GERD) related symptoms in a large patient population.
- Trial name
- PARADE (NCT00829738)
- Testing
- Pantoprazole
- Where
- 717 sites in Germany
- Volunteers
- 4,188 people
- Sponsor
- Nycomed
Functional Dyspepsia
Probiotics in Functional Dyspepsia
The goal of this clinical trial is to learn whether a multi-strain probiotic can reduce digestive symptoms and improve quality of life in adults with functional dyspepsia.
- Trial name
- ProPepsis (NCT07276009)
- Testing
- Lactobacillus
- Where
- Ukraine
- Volunteers
- 60 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Cognitive Assessment, Psychological Function
Snacks and Brain Health
This project will investigate whether daily snack consumption can improve memory, mood, and overall brain function in people with cognitive impairment.
- Conditions
- Cognitive Assessment, Psychological Function, GI Health
- Trial name
- NCT07348406
- Testing
- Pecan snack, Pretzel snack
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Texas Tech University Health Sciences Center
Cancer Pain, Visceral Pain
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes
Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL).
- Conditions
- Cancer Pain, Visceral Pain, Gastrointestinal Neoplasms, Cancer of Gastrointestinal Tract
- Trial name
- NCT04907643
- Testing
- PICO G2 4k
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Cedars-Sinai Medical Center
Gastrointestinal Disease, Gastrointestinal Disorders
Telehealth-Delivered Gut-Directed Hypnotherapy for Managing GI Health
This study aims to evaluate the specific and non-specific effects of hypnotherapy and to evaluate the efficacy of group-format gut-directed hypnotherapy (GDH) delivered via telehealth for managing gastrointestinal health.
- Conditions
- Gastrointestinal Disease, Gastrointestinal Disorders, Nervous System
- Trial name
- NCT06890663
- Testing
- Nonspecific Hypnotherapy for Relaxation, Gut-Directed Hypnotherapy (GDH), 3-month Follow-Up
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Central Florida
GI Issues, Bowel Movements
The Effect of Humiome® Post LB on Gut COMFort in healthY Adult Volunteers
The goal of this double-blind, randomized placebo-controlled study is to evaluate the effect of an 8-week supplementation of Humiome ® Post LB (170 mg) on bowel movements in healthy adult volunteers compared to Placebo adjusted…
- Conditions
- GI Issues, Bowel Movements, Gastrointestinal Symptoms
- Trial name
- NCT06937814
- Testing
- Humiome ® Post LB
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Cancer Metastatic, Symptoms and Signs
Symptom Management and Survivorship Plus Coaching for Advanced Cancer Survivors and Their Caregivers
The protocol will include a 10-week Symptom Management and Survivorship Handbook (SMSH) intervention to address informational needs for the management of physical and psychological symptoms, bundled with telephone delivered…
- Conditions
- Cancer Metastatic, Symptoms and Signs, Quality of Life
- Trial name
- SMSH and SMSH+ (NCT07415564)
- Testing
- Symptom Management and Survivorship Handbook + Coaching, Symptom Management and Survivorship Handbook
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
To Analyze TCM Syndrome and Symptoms of FGIDs Patients
Analysis of Gastrointestinal Symptoms of Outpatients With Functional Gastrointestinal Diseases（FGIDs） in Grade-A Tertiary Hospitals in China
To analyze the classification characteristics of gastrointestinal symptoms, the quality of life, the degree of anxiety and depression, and the satisfaction with the treatment of Chinese medicine in patients with FGIDs in Chinese…
- Trial name
- NCT04225559
- Where
- 16 sites in China
- Volunteers
- 4,632 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
GI Symptoms
Treatment of Upper Gastrointestinal Symptoms Using Hypnotherapy Sessions
The purpose of this research is to evaluate if hypnotherapy delivered digitally will help your GI symptoms.
- Trial name
- NCT06846359
- Testing
- Hypnotherapy, Educational module
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Autistic Disorder, Constipation
Impact of Improving Gastrointestinal Symptoms on Autism Symptoms and Oxidative Stress
The clinical manifestation of autism spectrum disorder (ASD) is complex, with medical and mental health disruptions that occur with the three core behavioral criteria used for diagnosis (social behavior, communication, restricted…
- Conditions
- Autistic Disorder, Constipation, Gastrointestinal Diseases
- Trial name
- NCT02442115
- Testing
- Treatment of Functional Constipation by
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital Los Angeles
Constipation
Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids
This study evaluates the addition of naloxegol (Movantik) to a laxative protocol in critically ill adults requiring scheduled opioid (e.g. fentanyl) therapy.
- Trial name
- NCT02977286
- Testing
- Naloxegol Oral Tablet, Docusate Sodium 100 Mg oral capsule [Colace], Senna 217 Mg Oral Tablet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Tufts Medical Center