Clinical trials: GI Symptoms
Irritable Bowel Syndrome (IBS)
Effects of HMOs on Faecal Microbiota, Gastrointestinal Symptoms, Mucosal Immunity and Barrier Function in IBS Patients
The study is a randomised, placebo-controlled, double-blind parallel study in IBS patients. A total of 60 adult patients diagnosed with IBS-C, -D or -A/M according to Rome IV criteria will be included.
- Trial name
- NCT02875847
- Testing
- HMO1, HMO2, Dextropur
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Glycom A/S
Gastrointestinal Symptoms, Infection
Assessment of Gastrointestinal Discomfort and Infections in Healthy Term Infants
A retrospective observational medical dossier-based study to assess gastrointestinal discomfort and infections in healthy term infants
- Conditions
- Gastrointestinal Symptoms, Infection, Allergy Symptoms, Growth
- Trial name
- MESK-1 (NCT06744699)
- Testing
- Infants fed goat milk-based infant formula
- Where
- 3 sites in Saudi Arabia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
GastroIntestinal Bleeding, Anticoagulant-induced Bleeding
Anticoagulation After GI Bleeding Pilot Study and Registry
PANTHER-GI Pilot Study will assess the feasibility of a full-scale multicentre cohort management study evaluating the safety of a standardized strategy for resuming direct oral anticoagulants (DOACs) after major DOAC-related…
- Trial name
- PANTHER-GI (NCT05290857)
- Testing
- Restart DOAC within 7 days of clinical hemostasis after GI bleeding, Restart DOAC between 7 to 14 days of clinical hemostasis after GI bleeding
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Irritable Bowel Syndrome With Diarrhea, Irritable Bowel Syndrome
Safety and Efficacy of a Probiotic Supplement in IBS-D
This study aims to assess the safety and efficacy of a single probiotic strain on symptom severity in adults with diarrhea-predominant Irritable Bowel Syndrome (IBS-D).
- Trial name
- IBIS (NCT05754177)
- Testing
- Probiotic
- Where
- Slovenia
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Effect of Kefir on Healthy Adults
Effects of Kefir Consumption on Health Outcomes: Gastrointestinal System, Immunity, Biochemical Parameters, Body Composition, Sleep Quality and Mental Well Being in Healthy Adults
The goal of this clinical trial is to evaluate the effects of the administration of kefir on gastrointestinal system, mental health, biochemical parameters, immunity and inflammation processes as well as the sleep quality…
- Trial name
- KefirCons (NCT06612164)
- Testing
- kefir
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Medipol University
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Low-output External Gastrointestinal Fistula
Glue Application in the Treatment of Low-Output Fistulas
Adjuvant use of fibrin glue (FG) in the fistula tract has been shown to promote closure of low-output enterocutaneous fistulas (ECFs).
- Trial name
- FG-treatment (NCT01828892)
- Testing
- Endoscopy exploration and glue application, Endoscopy exploration, Antibiotics (ceftazidime, cefotaxime, or meropenem, with or without vancomycin)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jinling Hospital, China
Pancreatic Cancer, Esophageal Cancer
HOPE - A Study to Evaluate the Effect of a Prehabilitation Program on GI Cancer Patients Planning to Undergo Surgery
A one-group prospective cohort study design with measures collected pre- and post-intervention. The primary goal of this study is to evaluate the effect of a multimodal prehabilitation preoperative program on changes in frailty…
- Conditions
- Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- HOPE (NCT03642093)
- Testing
- Nutritional Intervention, Physical Activity Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Siobhan Trotter
Pain, Postoperative
Evaluation of Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Sleeve Gastrectomy: A Prospective, Randomized, Controlled Clinical Trial
This study will help us in understanding the role of erector spinae block (ESPB) for postoperative pain control in patients undergoing upper GI laparoscopy surgeries.
- Trial name
- ESP (NCT04368195)
- Testing
- Erector spinae block
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Security Forces Hospital
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Heart Transplant Patients
Myfortic in Heart Transplant Patients With Gastrointestinal (GI) Symptoms
Stable heart transplant patients on Mycophenolate Mofetil (MMF) will sign a screening consent form in order to be evaluated with the gastrointestinal symptom rating scale (GSRS) questionnaire.
- Trial name
- NCT00468936
- Testing
- Myfortic
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Gastrointestinal Symptoms, Weight Loss
A Trial to Assess Gastrointestinal Responses to Dietary Fibers in Adults Using Weight Loss Medications
The objective of this study is to assess self-reported gastrointestinal (GI) responses to three snack bars containing fiber/fiber blends vs. a control snack bar for 7 days each in adults using GLP-1 agonists.
- Conditions
- Gastrointestinal Symptoms, Weight Loss, GLP-1
- Trial name
- NCT07012317
- Testing
- High Fiber Bar with Inulin, High Fiber bar with Fiber Blend, High Fiber Bar with Resistant Starch type 4
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Anorexia Nervosa
A Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN
The goal of this clinical trial is to determine if Fecal Microbiota Transplantation (FMT) is effective in treating Anorexia Nervosa (AN). The study will also explore how FMT works. The main questions it aims to answer are: 1.
- Trial name
- NCT06744751
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Constipation
Probiotics and Gut Health
Gastrointestinal discomfort regularly affects >25% of the population worldwide. One of the major contributors to Gastrointestinal discomfort is constipation, which has a prevalence of ~15%, and symptoms of which have a…
- Trial name
- NCT01874301
- Testing
- High quantity probiotic, Low quantity probiotic
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Société des Produits Nestlé (SPN)
Celiac Disease
Screen-detected Coeliac Disease, a Population Based Study
The purpose of this study is to determine the prevalence of previously undiagnosed coeliac disease based on a health survey from Tromsø, Norway. Moreover, the health impact of undiagnosed coeliac disease will be examined.
- Trial name
- NCT01695681
- Testing
- Gluten-free diet
- Where
- Norway
- Volunteers
- 172 people
- Sponsor
- University Hospital of North Norway
Upper Gastrointestinal Bleeding, Cirrhosis
Transfusion Requirements in Gastrointestinal (GI) Bleeding
Recently it has been suggested that a restrictive transfusion of units of Red Cells (URC) may improve the outcome of ICU patients with anemia.
- Conditions
- Upper Gastrointestinal Bleeding, Cirrhosis, Portal Hypertension
- Trial name
- NCT00414713
- Testing
- red blood cell transfusion
- Where
- Spain
- Volunteers
- 860 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Iron Deficiency Anemia Treatment, Microbial Colonization
GI Effects of Iron in Healthy Volunteers
Over recent years there has been a lot of research looking at how the bacteria in our gut affects our health. Some medications are known to cause changes in gut bacteria.
- Conditions
- Iron Deficiency Anemia Treatment, Microbial Colonization, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- NCT04705662
- Testing
- Lactulose breath test, Stool sample, Daily Diary
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr Anthony Hobson
Risk Factors, Complication of Surgical Procedure
ACUTE-Acute Surgical Care- Risk Factors and Outcomes for Patients in Need of Acute Surgical Care
Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.
- Conditions
- Risk Factors, Complication of Surgical Procedure, Complication of Treatment, Complication of Anesthesia
- Trial name
- ACUTE (NCT05195697)
- Testing
- Observational study of different treatments and time to treatment
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Region Skane
Unidentified Gastrointestinal Symptoms Following Pulses Consumption
Combining Cereals With Pulses - Reduced Gastrointestinal Symptoms?
The aim of the study is to compare self-reported gastrointestinal symptoms and intestinal fermentation rates of the study products as measured by breath hydrogen and methane in adult population with self-reported mild abdominal…
- Trial name
- NCT04273659
- Testing
- Pulses and cereals
- Where
- Finland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Turku
Celiac Disease
A Low FODMAPs Diet in Celiac Patients With Persistent Gastrointestinal Symptoms
FODMAPS (fructose, oligosaccharides, monosaccharides, disaccharides and polyols) are characterised as fermentable but poorly absorbed carbohydrates which enter the colon and are utilised by colonic bacteria.
- Trial name
- NCT02946827
- Testing
- Balanced low FODMAPs /gluten free diet, Balanced gluten free diet
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico