Clinical trials: GI Symptoms
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Advance Solid Tumors
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
This is a 2-part, first-in-human, open-label study to determine the safety and tolerability of KIVU-107, a PTK7-directed antibody-drug conjugate, in participants with locally advanced or metastatic solid tumors.
- Trial name
- NCT07229313
- Testing
- KIVU-107
- Where
- 7 sites in United States, Australia
- Volunteers
- 76 people
- Sponsor
- Kivu Bioscience Inc.
Menstrual Discomfort
Probiotic and Gastrointestinal Symptoms Due to Menstruation in Healthy Women
In this double blind, parallel study, female participants who are on an oral contraceptive will consume either a probiotic or placebo supplement for approximately 8 weeks.
- Trial name
- NCT04457401
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University of Florida
Gastro Intestinal Bleeding
Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding
Upper Gastrointestinal bleed is a common presentation in a medical emergency. Patients generally present with hematemesis, melena or in severe cases hematochezia.
- Trial name
- NCT04788121
- Testing
- Tranexamic acid, Standard of care
- Where
- India
- Volunteers
- 160 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Abdominal Pain, Deglutition Disorders
Evaluating the Impact of Automated Evaluation of Gastrointestinal Symptoms (AEGIS) on Clinical Outcomes
Healthcare delivery now mandates shorter visits with higher documentation requirements, undermining the patient-provider interaction.
- Conditions
- Abdominal Pain, Deglutition Disorders, Fecal Incontinence, Nausea
- Trial name
- AEGIS (NCT02530216)
- Testing
- AEGIS (Automated Evaluation of Gastrointestinal Symptoms)
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Cedars-Sinai Medical Center
Post-Colonoscopy Gastrointestinal Symptoms
Effect of Escherichia Coli 5C (Colipral®) on Post-Colonoscopy Gastrointestinal Symptoms
This prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of Escherichia coli 5C (Colipral®) in adult patients undergoing diagnostic colonoscopy.
- Trial name
- NCT07519616
- Testing
- Colipral®
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Gastrointestinal Problem, Anxiety
Effects of a Microalgae Extract Dietary Supplement on Gut Health, Anxiety, and Immune Function
This study will be conducted to determine the effect of daily Tetrasol consumption in supporting gut health using assessments of gastrointestinal symptoms (GSRS) and bowel habits (BSS) as primary outcome measures.
- Conditions
- Gastrointestinal Problem, Anxiety, Stress, Gastrointestinal Symptoms
- Trial name
- Tetrasol (NCT06425094)
- Testing
- Microalgae Extract Capsules
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Type 2 Diabetes, Obesity, Prediabetes
The Influence of Glucose Flux on Fat Synthesis in a Whole Body Calorimeter
The study is carried out to find out the inclusion of high and low glycaemic index foods to daily meals and how they impact 24 hour blood glucose fluctuations and energy regulation.
- Trial name
- NCT02631083
- Testing
- Breakfast, lunch, snack and dinner
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
COVID19 Disease
Gastrointestinal Symptoms in COVID-19
The coronavirus disease 2019 (COVID-19) initially developed at the beginning of December 2019 in Whuan, Hubei province of China has spread all over the world.
- Trial name
- NCT04691895
- Testing
- SARS-CoV2 infection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- University of Bologna
Non Erosive Reflux Disease, Chronic Gastritis
Esomeprazole Treatment Co-diagnosed Non Erosive Reflux Disease (NERD) and Chronic Gastritis Patients
To compare the symptom control rate between 8 weeks esomeprazole treatment regimen group and 2 weeks esomeprazole treatment regimen group in co-diagnosed NERD and chronic gastritis patients, as evaluated by GerdQ after 24 weeks…
- Trial name
- NCT01119768
- Testing
- Esomeprazole
- Where
- 8 sites in China
- Volunteers
- 305 people
- Sponsor
- AstraZeneca
Standard Quadruple Antiemetic Therapy, Electroacupuncture
Electroacupuncture for Chemotherapy-Induced GI Symptom Clusters in Breast Cancer
This study aims to elucidate the therapeutic efficacy of electroacupuncture in managing chemotherapy-induced gastrointestinal symptom clusters through clinical research.
- Conditions
- Standard Quadruple Antiemetic Therapy, Electroacupuncture, Chemotherapy-induced Gastrointestinal Symptom Cluster
- Trial name
- NCT06952920
- Testing
- electroacupuncture, standard quadruple antiemetic therapy
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Jiuda Zhao
Infectious Gastroenteritis
Implementation of a Molecular Diagnostic for Pediatric Acute Gastroenteritis: The FilmArray GI Panel IMPACT Study
BioFire Diagnostics, LLC (BioFire) has developed the FilmArray Gastrointestinal (GI) Panel, a rapid, easy to use PCR-based in vitro diagnostic test for the identification of 22 common microorganisms responsible for infectious…
- Trial name
- IMPACT (NCT02248285)
- Testing
- FilmArray™ Gastrointestinal (GI) Panel
- Where
- 5 sites in United States
- Volunteers
- 1,545 people
- Sponsor
- BioFire Diagnostics, LLC
Lactose Intolerance
Does Daily Supplementation of Lactobacillus Acidophilus MPH734, for One Week, Affect Acute (Immediate), Subacute (7 Days), and Post-treatment Discontinuation Lactose Metabolism, Gastrointestinal Symptoms, and Clinical Markers of Inflammation and Safety Compared to a Placebo
The purpose of this study is to determine if twice or three times daily supplementation of Lactobacillus acidophilus MPH734 (Lacto-FreedomTM, or LF), for one week, affects acute (immediate), subacute (7 days), and post-treatment…
- Trial name
- LF (NCT04531033)
- Testing
- Lactobacillus acidophilus MPH734
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lemuel W. Taylor IV
Systemic Sclerosis, Scleroderma
Effects of Probiotics on Gastrointestinal Symptoms and on the Immune System in Patients With Systemic Sclerosis
Systemic sclerosis (SSc) is an autoimmune disease with unknown etiology, which affects especially the gastrointestinal tract, lungs, heart and kidneys.
- Trial name
- SSc (NCT02302352)
- Testing
- Probiotic
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Healthy
Effects of a Placebo Probiotic on Gut Health and General Well-being in Individuals With Mild Gastrointestinal Symptoms
The present study is aimed at exploring whether positive expectations of receiving a three-week treatment with a probiotic supplement (in fact a placebo) improve symptoms of gastrointestinal distress and promote physical and…
- Trial name
- PlaCIBO (NCT06720558)
- Testing
- Control-no treatment
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Children With Autism
FMT in Children With Autism and Gastrointestinal Symptoms
1. ASD children with gastrointestinal problems that interfere with daily routine will be recruited at the center for Autism led by Prof Zachor, and at the Pediatric Neurology \& Development Center at Shamir Medical Center.
- Trial name
- NCT04246398
- Testing
- FMT
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Assaf Harofeh MC
Autism Spectrum Disorder, Autism
Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Autism Spectrum Disorder and Associated GI Symptoms (SPROUT)
Adolescent autism spectrum disorder subjects with associated GI symptoms will be randomized to receive oral dosing of CP101 capsules in Treatment Group I or matching placebo capsules in Treatment Group II.
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autistic Thinking
- Trial name
- SPROUT (NCT03829878)
- Testing
- CP101
- Sponsor
- Finch Research and Development LLC.
Atrial Fibrillation, GI Bleeding
Left Atrial Appendage Closure With WATCHMAN FLX Device in Recurrent Gastrointestinal Bleeding: The GI-FLX Registry
The GI-FLX Registry is intended to create a registry of patients with a history of Atrial Fibrillation (AF) and Gastrointestinal (GI) bleed who will receive Left Atrial Appendage Closure (LAAC) with WATCHMAN FLX device and…
- Trial name
- NCT06052358
- Testing
- LAAC with Watchman FLX device
- Where
- 4 sites in United States
- Volunteers
- 73 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
NCGS, Gluten
Effect of Acute and Sub-acute Administration of Gluten on Extra-intestinal and Gastrointestinal Symptoms in Patients With Non-coeliac Gluten Sensitivity
The investigators will investigate the effects of acute and sub-acute administration of gluten on mood, intestinal permeability, gastrointestinal symptoms, gut microbiota and cortisol levels in NCGS patients.
- Trial name
- NCT03798249
- Testing
- Gluten
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Graft Versus Host Disease
Beclomethasone Plus Prednisone in Treating Patients With Graft-Versus-Host Disease
RATIONALE: Beclomethasone combined with prednisone may be an effective treatment for graft-versus-host disease caused by stem cell transplantation.
- Trial name
- NCT00043147
- Testing
- beclomethasone dipropionate, methylprednisolone, prednisone
- Where
- 2 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center