Clinical trials: GI Tract Disorders
Disorder of Upper Digestive Tract
Near Infrared Optical Coherence Tomography of the Upper Aero-Digestive Tract
The Optical Coherence Tomography is a minimally-invasive diagnostic tool in both the office and operating room settings can identify sources of airway obstruction and effective surgical interventions.
- Trial name
- NCT00544427
- Testing
- Optical coherence tomography
- Where
- 3 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Alcohol Use Disorder
Broccoli Extract Supplementation in Older Adults With Alcohol Use Disorder
Chronic alcohol consumption leads to perturbations in gut microbiome balance (dysbiosis) and disruption of gut barrier integrity.
- Trial name
- NCT05902754
- Testing
- Generally Recognized as Safe - Sulforaphane
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Childhood Obesity, Life Style
LIMIT Early Adiposity Rebound in Children
Childhood obesity is a strong predictor of adult obesity with health and economic consequences for the individual and society. Adiposity rebound (AR) is a rise in the Body Mass Index occurring between 3-7 years.
- Conditions
- Childhood Obesity, Life Style, Intestinal Microbiome
- Trial name
- LIMIT (NCT04960670)
- Testing
- Evaluation of microbiome and maternal/infant lifestyle
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Immune System, Stress
Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals
The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.
- Conditions
- Immune System, Stress, Chronic Stress, Cardiovascular Health
- Trial name
- NCT07735221
- Testing
- Peanuts, roasted, salted with skins, Isocaloric food
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
To Assess Feasibility of the New Application
Diagnosis of Fatty Pancreas by FibroScan
Example 2: Interventional study The goal of this observational study is to learn know about the use of FibroScan in diagnosis of fatty pancreas in obese and non obese patients which done for the first time at worldwide as well as…
- Trial name
- FattyPancreas (NCT07255989)
- Testing
- meeting about the nutrition
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Benha University
SARS-CoV2 Infection, COVID-19, Gut Microbiota, Mucosal Response, Children
COVID-19 and Intestinal Microbiota in Children
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. It appears to cause only mild to moderate upper respiratory symptoms in children, in addition to gastrointestinal symptoms resulting from its penetration into intestinal…
- Trial name
- NCT06503887
- Testing
- Stool sample collection
- Where
- Lebanon
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Hypertension, Gut Dysbiosis
The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health
The purpose of this study is to see the effect of 30 days of synbiotic vs. probiotic supplementation (usingJuice+ nutrition products) on body weight, metabolism, cardiovascular health, and gut health.
- Conditions
- Hypertension, Gut Dysbiosis, Overweight , Obesity
- Trial name
- NCT07515443
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Southern Utah University
Cystic Fibrosis
Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior
Recently trial data has shown that the medicine KaftrioTM (Elexacaftor/ Tezacaftor/ Ivacaftor) improves lung function in children aged 6 to 11 years who have cystic fibrosis (CF).
- Trial name
- GIFT-CFJunior (NCT05699148)
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Metabolic Syndrome, Healthy Participants
Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes
Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity.
- Conditions
- Metabolic Syndrome, Healthy Participants, Metabolically Healthy Obesity, Metabolically Abnormal Obesity
- Trial name
- NCT07095426
- Testing
- inulin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ball State University
Aging, Undernutrition
Determination of In-vivo Plasma AA Appearance From Plant Protein Fibre Products
This study aims to assess the digestibility and efficacy of the study groups previously developed innovative plant-based protein and fibre products.
- Conditions
- Aging, Undernutrition, Appetite Loss, Age-Related Sarcopenia
- Trial name
- NCT05420142
- Testing
- Net peripheral AA appearance following ingestion of 3 selected PPF products compared to whey
- Where
- 2 sites in Ireland, Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Multiple Sclerosis
Deciphering the Role of the Gut Microbiota in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory disease that affects the nervous system and results in a wide range of signs and symptoms including physical and cognitive problems.
- Trial name
- NCT02580435
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Esophageal Cancer, Nutrition Disorders
Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
The incidence of oesophagogastric cancer has increased by 400% since the 1970s in Ireland and the United Kingdom. In addition, refinement of perioperative management and the now widespread use of multimodal protocols for patients…
- Conditions
- Esophageal Cancer, Nutrition Disorders, Appetite Disorders, Dumping Syndrome
- Trial name
- EndoGut (NCT03734627)
- Testing
- Octreotide Acetate, Saline Solution, Paracetamol
- Where
- 2 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
ADHD
Improving ADHD Symptoms and Quality of Life Through Diet
The goal of this randomised controlled trial is to evaluate whether a specific dietary intervention can reduce core symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in adults aged 18 to 50 years.
- Trial name
- ADAPT (NCT07376746)
- Testing
- Combined diet
- Where
- Ireland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University College Cork
CKD, Uremia
Impact of Intestinal Microbiota on Uremic Toxins Productions
Chronic renal failure (CKD) affects 3 million people in France and is characterized by the accumulation of uremic toxins (UTs) such as p-cresyl sulfate (PCS) and indoxyl sulfate (IS) which participate in cardiovascular…
- Trial name
- GUTCOL (NCT04768309)
- Testing
- Ex vivo exploration of the effect of a probiotic over precursor indole production
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Microbial Colonization
Effect of Galacto-oligosaccharides (GOS) on Faecal Gut Microbiota in Adult Women
Within the Denali study the effect of 3 weeks intervention with GOS on the abundance of Bifidobacterium in faecal samples will be investigated.
- Trial name
- Denali (NCT05762965)
- Testing
- GOS 1, GOS 2
- Where
- Netherlands
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Esophageal Cancer, Bile Duct Neoplasms
Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract
Doctors at Memorial Sloan Kettering Cancer Center and at other institutions study normal and cancer cells. To study these cells we need to have human tissue, body fluids, and blood.
- Conditions
- Esophageal Cancer, Bile Duct Neoplasms, Gastric Cancer, Liver Cancer
- Trial name
- NCT00582647
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastrointestinal, Overweight , Obesity
A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Impact of CLB101TM️ on Gut Health in Healthy, Overweight Individuals
Anaerostipes caccae CLB101TM️ is a next-generation probiotic isolated from healthy humans. It was shown to be in decreased abundance in people with protein-based food sensitivities/allergies.
- Trial name
- NCT07336615
- Testing
- CLB101™️
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- ClostraBio Inc.
Irritable Bowel Syndrome, Inflammatory Bowel Diseases
The Ecological Role of Yeasts in the Human Gut
Irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) (categorised into Crohn's disease (CD) and ulcerative colitis (UC)) are chronic gut disorders with debilitating symptoms that profoundly impact quality of life…
- Conditions
- Irritable Bowel Syndrome, Inflammatory Bowel Diseases, Gastrointestinal Disease
- Trial name
- YIG (NCT04138225)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Grace Ward
Obesity, Insulin Resistance
Targeting the Gut Microbiome to Investigate the Pathways of Progression From Obesity to Metabolic Diseases in an At-risk Population.
Studies of the human gut microbiome have suggested that treatment or prevention aimed at the obese microbiome could influence the development of obesity-associated metabolic disturbances.
- Trial name
- NCT01433120
- Testing
- Lactobacillus paracasei ssp paracasei F19, Flax seed fibres
- Where
- Denmark
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Late Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn
Gut Priming With Oral Bovine Colostrum for Preterm Neonates; Randomized Control Trial
The aim was to assess the ability of bovine colostrum concentrate to reduce the incidence of late-onset sepsis episodes and necrotizing enterocolitis in artificially fed preterm neonates and its effect on T regulatory cells.
- Conditions
- Late Onset Neonatal Sepsis, Necrotizing Enterocolitis of Newborn, Feeding; Difficult, Newborn
- Trial name
- NCT03926390
- Testing
- Bovine colostrum
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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