Clinical trials: GI Tract Disorders
IBS - Irritable Bowel Syndrome
Study to Evaluate the Efficacy of Poppi Apple Cider Vinegar Prebiotic Soda to Improve Gut Health In Participants
This exploratory observational trial provides the opportunity to gather information on the effect of daily consumption of Poppi Apple Cider Vinegar Prebiotic Soda on gut health and digestion.
- Trial name
- NCT05418439
- Testing
- Drink Poppi Soda
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Drink Poppi
Autism Spectrum Disorder
Intestinal Microbiota, Tryptophan and Autism
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation.
- Trial name
- MTA (NCT03751930)
- Testing
- Samples
- Where
- 2 sites in France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Obesity, Overweight
The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children
This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).
- Conditions
- Obesity, Overweight, Type 1 Diabetes Mellitus
- Trial name
- NCT02938806
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Type 2 Diabetes
Macronutrients and Gut Hormone Secretion
Study hypothesis is to examine the relative contribution of macronutrients for gut hormone secretion after a mixed meal in healthy volunteers and in subjects with type 2 diabetes.
- Trial name
- NCT01366794
- Testing
- Macronutrients
- Where
- 2 sites in Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Lund University
Gut Microbiota, Hepatocellular Carcinoma
The Effect of Gut Microbiota on Postoperative Liver Function Recovery in Patients With Hepatocellular Carcinoma
The purpose of this study was to explore the correlation between postoperative recovery of liver function and gut microbiota in patients with hepatocellular carcinoma (HCC).
- Trial name
- NCT04303286
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
COPD, Microbial Colonization
Partially Hydrolyzed Guar Gum (PHGG) for Amelioration of Chronic Obstructive Pulmonary Disease (COPD)
Some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health.
- Conditions
- COPD, Microbial Colonization, Respiratory Tract Disease
- Trial name
- NCT05126654
- Testing
- Partially Hydrolyzed Guar Gum (PHGG)
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Vitiligo, Healthy
The Gut and Skin Microbiome in Vitiligo Disease Progression
Investigators plan to perform a pilot study that aims to characterize the microbiome of human vitiligo patients with both active and stable disease and compare this to the microbiome of age and sex matched controls.
- Trial name
- NCT03577327
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northwestern University
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Long COVID, Brain Fog
Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID
The goal of this clinical trial is to test whether the intervention of probiotics supplement can improve symptoms of long covid syndrome. Participants will be given probiotics or placebo capsules for two month.
- Conditions
- Long COVID, Brain Fog, Cognitive Change
- Trial name
- COVID-19 (NCT06348212)
- Testing
- Lactobacillus paracasei PS23, microcrystalline cellulose
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Intestinal Microbiota Between Different Groups
Impact of Direct-acting Antiviral Drugs on The Patterns of Gut Microbiota in Patients With HCV Related Chronic Liver Diseases
The recent introduction of direct-acting antiviral (DAA) therapy has dramatically changed the rates of cure of HCV infection even in difficult to treat subjects and in those with severe comorbidities .
- Trial name
- NCT06829966
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mild Cognitive Impairment, Alzheimer Disease
Effects of Yeast Beta-glucan on Cognitive Function in Patients With Mild Cognitive Impairment
Patients with mild cognitive impairment aged 50-80 years old were recruited in Shiyan City, Hubei Province, and divided into intervention group and placebo group.
- Trial name
- NCT06083350
- Testing
- Yeast beta-glucan, Starch
- Where
- 2 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Xiaofan Xu
Colorectal Cancer (CRC), Endocrine Disruptors
Effects of Endocrine Disruptors on the Gut Microbiota and Assessment of Their Impact on Colorectal Cancer Development (PERMICA)
Colorectal cancer is the third most common cancer worldwide, yet it was the second leading cause of cancer-related deaths in 2020. The average French population faces a colorectal cancer risk partly linked to lifestyle factors.
- Conditions
- Colorectal Cancer (CRC), Endocrine Disruptors, Microbiota, Dysbiosis
- Trial name
- PERMICA (NCT06809660)
- Testing
- Collection of biological samples and clinical data
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Glucose Metabolism Disorders, Obesity
Effect of Meal Texture on Glucose-metabolism and Gut Hormone Response After Bariatric Surgery
The investigators want to evaluate the difference in glucose metabolism and intestinal hormonal response after a liquid meal versus a solid meal in patients after bariatric surgery.
- Conditions
- Glucose Metabolism Disorders, Obesity, Sleeve Gastrectomy, Gastric Bypass
- Trial name
- Obesity (NCT04082923)
- Testing
- Liquid meal, Solid meal
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Postprandial Hyperglycemia, Metabolic Disorder, Glucose
Westlake N-of-1 Trials for Macronutrient Intake 2 ( WE-MACNUTR 2)
Diet and nutrition are key to maintain human health. Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR) trial investigates individualized postprandial glycemic responses to different proportions of dietary fat and…
- Trial name
- NCT05161182
- Testing
- High fat, low carbohydrate diet, Low fat, high carbohydrate diet
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Westlake University
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Ulcerative Colitis
The Effect of Therapeutic Fecal Transplant on the Gut Microbiome in Children With Ulcerative Colitis
Ninety Six patients with mild to moderate ulcerative colitis will be randomized to double blind, placebo controlled study. The safety and efficacy of the intervention will be closely monitored.
- Trial name
- FMT_UC (NCT02291523)
- Testing
- Fecal Microbial Transplant
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM)
Research on Gut Microbiota and Metabolomics in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by high prevalence, multiple pathogenesis, and lack of effective treatment and management strategies.
- Conditions
- Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- NCT06833541
- Where
- China
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Obesity (BMI Equal to or >30), Immune Function
Investigation of Egg Intake and the Relationship Between Gut Microbiome, Metabolic, and Immune Profiles
The purpose of this intervention study is to investigate the effects of daily egg intake on markers of gut health, high-density lipoprotein (HDL), metabolic, and immune cell profiles in adults with body mass indexes (BMI) in…
- Conditions
- Obesity (BMI Equal to or >30), Immune Function, HDL, Gut Microbiome
- Trial name
- NCT07844616
- Testing
- Egg whites, Whole eggs
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy, Periodontitis
Oral and Gut Microbiota Changes During Long-term Fasting in Humans
The aim of this longitudinal trial is to investigate the effects of a 10±3-day fasting period in 30 subjects. Changes in the oral and gut microbiota, halitosis, as well as inflammatory and antioxidative parameters and biomarkers…
- Trial name
- OralFast (NCT05449249)
- Testing
- Long-term fasting
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
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