Clinical trials: GI Tract Disorders
Parkinson Disease (PD), PARKINSON DISEASE (Disorder)
GBPDC: Gut-Brain in PD Consortium Master Protocol
The purpose of this research study is to identify the role that the gut-brain axis, the group of nerves that connect the brain and gut, plays in Parkinson's disease (PD).
- Conditions
- Parkinson Disease (PD), PARKINSON DISEASE (Disorder), Gut Microbiome, Gut Microbiota
- Trial name
- GBPDC (NCT07567794)
- Where
- 7 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University
Irritable Bowel Syndrome
Effects of Activia in IBS
The purpose of this study is to investigate the association between gut microbiota, immunology and typical pathophysiological factors in patients with IBS (all subtypes) AND to assess the effect of Activia consumption on GI…
- Trial name
- MOSAIC (NCT01252550)
- Testing
- Activia® (125g/pot), Acidified non-fermented dairy product
- Where
- 3 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Gastrointestinal Diseases
Probiotics Improve Health Young Volunteers' Gut Microbiota
The goal of this clinical trial is to evaluate whether daily supplementation with the probiotic Bifidobacterium breve BBr60 can improve metabolic, gastrointestinal, and emotional health in healthy adult volunteers aged 19 to 45…
- Trial name
- NCT06196892
- Testing
- Probiotic BBr60
- Where
- China
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Severe Acute Malnutrition
Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children
1. RUTF would be more effective (quicker catch-up growth by promoting more tissue accrue resulting decrease stay in rehabilitation ward) in treating children with SAM during the rehabilitation phase than khichuri /halwa; 2.
- Trial name
- RUTF (NCT01331044)
- Testing
- Plumpy Nut, Khichuri and Halwa
- Where
- Bangladesh
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Healthy Subjects, Pre-diabetes
Red Raspberry Polyphenols on Gut Microbiome
The primary objective aims are to assess the effects of regular consumption of red raspberries (RRB) with and without fructooligosaccharide (FOS) on the composition of the gut microbiota after 4 week intake and in parallel…
- Trial name
- RRB2 (NCT03049631)
- Testing
- Raspberry and fructooligosaccharide, Raspberry
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Vitamin B 12 Deficiency
The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota
Vitamin B12 plays important roles in DNA synthesis and neurological functions. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants.
- Trial name
- NCT03365583
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Marmara University
Osteoporosis, Obesity
Impact of Milk and Yogurt Supplementation on Bone Health, Body Composition, and Gut Microbiota in Canadian Young Adults
Milk and dairy products contain significant amounts of nutrients that contribute to optimal health - nutrients like calcium, vitamin D, and high-quality protein.
- Trial name
- NCT06265246
- Testing
- Habitual Diet + Milk, Habitual Diet + Yogurt
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Autoimmune Hepatitis, Primary Sclerosing Cholangitis
Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome
In this study, we aim to identify gut microbiomes specific to patients with chronic refractory liver disease and to conduct a gut-liver axis study on the pathogenesis and disease progression.
- Conditions
- Autoimmune Hepatitis, Primary Sclerosing Cholangitis, Non-Alcoholic Fatty Liver Disease, Liver Abscess
- Trial name
- LGAS (NCT06519162)
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
Iron Deficiency (Without Anemia)
Effect of Low-dose Versus Standard-dose Iron Supplementation on the Gut Microbiome
Iron deficiency is a common problem that is often treated with the administration of oral iron. Most of the iron is not absorbed and remains in the intestine, where it influences the balance of gut bacteria.
- Trial name
- NCT05467423
- Testing
- Iron
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Atopic Dermatitis, Healthy
Assessment of Clinical, Biological and Biometrological Parameters in Adults Subjects With Atopic Dermatitis
In most recent years, the gut microbiome has been highlighted as a key player in the control of organs distant from the gut. Indeed, studies have raised evidence that gut microbiota exerts a control on various diseases including…
- Trial name
- NCT07017348
- Testing
- Clinical assessments, Biometrological measurements, Biological sampling
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Dermo Cosmetique
HIV Infections, Immune Activation
The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study
Background Commencement of lifelong highly active antiretroviral therapy (HAART) immediately after HIV diagnosis (option B+), for treatment of human immunodeficiency virus (HIV), has greatly improved maternal-infant health in sub…
- Conditions
- HIV Infections, Immune Activation, Comorbidities
- Trial name
- UZ-CHS-BC (NCT04087239)
- Testing
- HIV
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Overweight , Obesity, Glucose Metabolism
SucroMet Nutritional Intervention Trial
SucroMet is designed to evaluate how adding two commonly used sweeteners-sucrose (table sugar) and sucralose (a low-calorie sweetener)-at low and high doses may influence glucose regulation, including insulin resistance and…
- Trial name
- NCT07656298
- Testing
- Sucrose- Low dose, Sucrose - High Dose, Sucralose - Low Dose
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Obesity (Disorder)
Three M Study (Malabsorption, Microbiota, Mini-Gastric Bypass)
Bariatric surgery represents the best therapeutic option to induce sustainable weight loss and to solve serious comorbidities improving the life-expectancy and the quality of life.
- Trial name
- NCT03412149
- Testing
- Mini Gastric Bypass, Roux en Y Gastric Bypass
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Lymphocytic Enteritis (Disorder), Healthy Volunteers
Evaluation of the Lymphocyte Subpopulations in the Normal Mucosa of the Upper Digestive Tract
The macro and microscopic findings of the upper gastrointestinal tract are useful in the differential diagnosis of digestive diseases such as Crohn's or celiac diseases.
- Trial name
- GUTproject (NCT05084807)
- Testing
- Endoscopy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Hypertension
The Role of Gut Microbiota in Hypertension
Hypertension is the single most prevalent risk factor for heart diseases, heart failure, kidney failure and stroke. About 1 in 3 adults in the United States have hypertension.
- Trial name
- NCT02188381
- Testing
- Stool Sample and Blood Sample
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University of Florida
COVID-19-Associated Encephalitis, Long COVID
Longterm Influence of Pediatric Long COVID Syndrome
We enroll pediatric patients who were diagnosed COVID-19 for main observation target. We will perform brain MRI and neuropsychiatric evaluation 4-6 months after COVID-19 diagnosed.
- Trial name
- NCT05566392
- Testing
- Brain MRI
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Crohn's Disease, CAM
Efficacy of Acupuncture and Moxibustion Treatment in Patients With Quiescent Crohn's Disease:Evaluation With fMRI
The purpose of this study is to determine whether acupuncture or moxibustion therapies are effective in the treatment of Crohn's disease.
- Trial name
- NCT01696838
- Testing
- electroacupuncture, moxibustion
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Type 2 Diabetes Mellitus, Dyslipidemias
Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes
Microbiota is important for immunology, hormonal and metabolic homeostasis in human and could influence on developing diabetes and obesity.
- Trial name
- NCT03204799
- Testing
- Metformin, SGLT2 inhibitor, ezetimibe
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Digestive Tract Diseases, Liver Diseases
Tongue Image Database and Diagnostic Model for Digestive Tract Disease Diagnosis
The tongue images of patients with gastrointestinal diseases and healthy people will be collected and the tongue image database will be established.
- Conditions
- Digestive Tract Diseases, Liver Diseases, Colorectal Disease, Gastric Diseases
- Trial name
- NCT05182983
- Testing
- Tongue images，coating on the tongue and clinical data
- Where
- China
- Volunteers
- 10,690 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
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