Clinical trials: GI Tract Disorders
Overweight
Effect of Dietary Intervention on Gut Microbiome in Hong Kong Obese Population
Modern way of life characterized by decreased physical activity and poor dietary habits seems to be an important trigger for the onset of metabolic disorders.
- Trial name
- NCT03343561
- Testing
- Nutrition Advice
- Where
- Hong Kong
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Post Bariatricsurgery, Hypoglycemia
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
RYGB (roux-en-y gastric bypass) has been reported to reverse type 2 diabetes (T2DM) immediately after surgery before any significant weight loss.
- Trial name
- NCT00992901
- Testing
- Exendin-(9-39), Atropine, GLP-1 and GIP
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Disease of Lower Digestive Tract, Nurse-Patient Relations
Design and Clinical Application of Colonoscopy Position Identification Sheet
Before colonoscopy, the nursing staff need to educate the patient with posture coordination.However, it is difficult for some patients to understand the placement of the correct body position, which takes too much time to conduct…
- Trial name
- NCT05239481
- Testing
- colonoscopy position identification sheet, Traditional disposable cleaning sheet
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Human Microbiota, PreTerm Birth
The Reproductive Microbiome & Perinatal Health Outcomes
Pregnant African American women between 18 and 45 years of age will be enrolled at 20 weeks of gestation or less. Biological specimens (vaginal swabs, rectal swab) will be collected at enrollment, 23-24 weeks, at 28-29 weeks, and…
- Conditions
- Human Microbiota, PreTerm Birth, Human Gastrointestinal Microbiota, Metabolomics
- Trial name
- NCT02948192
- Testing
- Survey, Sample collection
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
MTBI - Mild Traumatic Brain Injury
Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and…
- Trial name
- NCT05090007
- Testing
- magnetic resonance image, gut microbiota
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Gestational Diabetes, Pregnancy Related
Gut and Oral Microbiome of GDM Patients During Pregnancy
The study aimed to clarify the characteristics of the intestinal and oral microbiome of Gestational Diabetes Mellitus(GDM) patients during the whole pregnancy, try to clarify the relationship between the microbiome and GDM.
- Trial name
- NCT04420507
- Where
- China
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Anxiety, Panic Disorder
Investigation of Pathogenic Gut Microbiota Patterns in Anxiety, Depression and Panic Disorders
This study aims to investigate the etiology of anxiety, depression, and panic disorders, providing new evidence and insights into the root causes and effective treatments, potentially offering a novel approach to achieving…
- Conditions
- Anxiety, Panic Disorder, Mood Disorders, Depression
- Trial name
- NCT07268729
- Testing
- H pylori stool test, Bacterial stool analysis
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Toronto
IBD (Inflammatory Bowel Disease), IBD
Exploring Fecal Calprotectin Levels, Maternal and Infant Microbiota, Infant Health, Nutrition, and Adverse Pregnancy Outcomes With Patient With Inflammatory Bowel Disease
The goal of this prospective longitudinal cohort study is to examine how the human microbiome of pregnant women-including bacteria and fungi in the gastrointestinal tract, vaginal canal, skin, and breastmilk-may influence infant…
- Conditions
- IBD (Inflammatory Bowel Disease), IBD, IBD - Inflammatory Bowel Disease, Pregnancy
- Trial name
- CALINA-IBD (NCT07385807)
- Where
- 2 sites in Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Colorectal Cancer
The Role of Gut Microbiome and Chronic Inflammation in Young-onset Colorectal Cancer
This study aims to investigate the role of gut microbiome pattern and inflammation marker NF-ҡB in young-onset colorectal cancer
- Trial name
- NCT04011969
- Testing
- Score assessment, Blood sampling, Fecal sampling
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Obesity, Depressive Symptoms
The MIND-GUT Digital Pilot Intervention Study
This 12-week pilot study aims to evaluate the feasibility and effectiveness of a dietary intervention targeting diet, obesity, mental health, and the gut microbiome in promoting weight loss and enhancing mental health among obese…
- Conditions
- Obesity, Depressive Symptoms, Anxiety, Stress
- Trial name
- MINDGUT (NCT06374407)
- Testing
- Dietary intervention based on the MIND diet
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Skövde
Binge Eating Behaviour
Influence of Appetite Related Hormones in Binge Eating Behaviour Among the Overweight and Obese
Malaysia has increasing challenges in lifestyle related diseases, which is related to eating habits and disorders. According to the National Health \& Morbidity Survey in 2011; it was reported the prevalence of obesity is 15.1%…
- Trial name
- NCT01739049
- Testing
- Liraglutide, Diet and Exercise
- Where
- Malaysia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Premature Intestinal Microbiota, Necrotizing Enterocolitis
Defining the Intestinal Microbiota in Premature Neonates
The investigators will collect daily faecal samples from premature (<32 weeks) infants in the intensive care unit from the day of birth until they are discharged.
- Conditions
- Premature Intestinal Microbiota, Necrotizing Enterocolitis, Late Onset Bloodstream Infection
- Trial name
- NCT01102738
- Where
- 3 sites in United Kingdom
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Clinical Infection, Microbial Colonization
Effect of Gut Microbiota and Fecal Inflammatory Marker on Childhood Gastroenteritis
Childhood gastroenteritis establishes gastrointestinal disease and increase the economic burden, and the pediatric population is especially vulnerable to these gastrointestinal infections.
- Conditions
- Clinical Infection, Microbial Colonization, Gastroenteritis, Inflammatory Response
- Trial name
- NCT03856138
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy Patient on Good Condition
Study of the Feasibility of Magnetic Navigated Capsule Endoscope in the Upper Gastrointestinal Tract Examination
External control of capsule endoscopy (CE) by means of an applied magnetic field is a possible way to maneuver the movement of CE in gastrointestinal (GI) tract.
- Trial name
- NCT02886338
- Testing
- capsule endoscopy
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Depressive Disorder, Major
Probiotics and the Gut Brain Axis- Do Probiotics Interact With the Vagal Nerve?
The purpose of this study is to investigate the effects of a multispecies probiotic on the function of the vagal nerve in patients with major depression and healthy participants in a single-center, randomized, placebo-controlled…
- Trial name
- ProBIO-HRV (NCT04772664)
- Testing
- Multispecies-Probiotic
- Where
- Austria
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Metabolic Diseases, Immune System Disorder
Study on the Effects of Wheat and Corn Germ Blend Oil on Antioxidation and Immune Regulation of Dyslipidemia Population
The goal of this clinical trial is to explore the role of wheat and corn germ blended oils in regulating oxidative stress and immunomodulation in dyslipidaemic populations, to explore their effects on intestinal flora…
- Conditions
- Metabolic Diseases, Immune System Disorder, Dyslipidemias, Fatty Acid Metabolism Disorder
- Trial name
- NCT06060509
- Testing
- Phytosterol-rich Wheat and Corn Germ Blended Oil, Peanut oil
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Gout, Hyperuricemia
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout
To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
- Conditions
- Gout, Hyperuricemia, Gut Microbiota, Uric Acid
- Trial name
- NCT04953533
- Testing
- no intervention
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Normal Weight
Impact of the Timing of Pasta Consumption on Health
To date, the optimal timing for pasta consumption remains uncertain. Based on recent evidence in the field of chrono-nutrition, it is speculated that eating pasta at dinner may have a negative impact on cardio-metabolic health.
- Trial name
- NCT06185634
- Testing
- Dietary intervention - Pasta at dinner, Dietary intervention - Pasta at lunch
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Premature Birth of Newborn
Enteral Feeding and Early Gut Colonization of Preterm Infants
The aim of this study is to evaluate the potential role of the enteral feeding systems on the bacterial colonization of premature infants during their NICU admittance and its evolution after 2 years, which is the age when the…
- Trial name
- PRECOL (NCT02502916)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Anxiety and Depression, Disorders of Gut-brain Interaction
Development of an Online ACT Intervention for Disorders of Gut-Brain Interaction
The goal of this clinical trial is to develop and test the iACTforDGBI intervention in a sample of Swedish individuals with DGBI (Disorders of Gut-Brain Interaction).
- Trial name
- iACTforDGBI (NCT06309004)
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden