Clinical trials: GI Tract Disorders
Chronic Low Back Pain (CLBP), Chronic Insomnia
Studying the Neurobiological Mechanisms of Non-specific Chronic Low Back Pain and Chronic Insomnia: a Four-group Cross-sectional Study
This study is a part of a larger project aiming to evaluate the neurobiological mechanisms underlying the relationship between sleep and pain in people with non-specific chronic low back pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Insomnia, Neuroinflammation
- Trial name
- SY-NAPS-CS (NCT06973837)
- Testing
- Real-life monitoring, experimental pain testing, brain imaging, blood and stool sampling.
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Digestive Disease, Gut Health
Impact of B. Adolescentis iVS-1 Probiotic on Gastrointestinal Outcomes
The study team is conducting a consumer-driven, decentralized clinical research study to assess the impact of the consumer-grade probiotic supplement, iVS-1, on adults with moderate to severe gastrointestinal discomfort.
- Trial name
- NCT07408518
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Synbiotic Health
Metabolic Disease, Immune Function
Omega 3 and Fibre Intervention Study to Improve Metabolic Health
Metabolic syndrome represents a major health burden worldwide affecting 20-30% of the population. This clustering of abnormalities that confers an increased risk of cardiovascular disease and type 2 diabetes mellitus, is the…
- Conditions
- Metabolic Disease, Immune Function, Cardiovascular Diseases, Systemic Inflammation
- Trial name
- NCT03442348
- Testing
- Omega 3 fatty acid, Inulin fibre
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Obesity, Insulin Resistance
Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge.
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes, Exercise Training
- Trial name
- CROSSYS (NCT03730610)
- Testing
- Exercise training
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Turku
Fetal Growth Restriction, Gut Microbiota
Gut Microbiota, SCFAs and Glucolipid Metabolism in Pregnant Women With Abnormal Fetal Size and Their Newborns
Abnormal fetal size includes fetal growth restriction and fetal macrosomia. Onset is closely related to maternal nutrition metabolism.
- Conditions
- Fetal Growth Restriction, Gut Microbiota, Fetal Macrosomia, Glucolipid Metabolism
- Trial name
- NCT04399434
- Testing
- test gut microbiota, SCFAs and glucolipid metabolism and insulin sensitivity
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Esophageal Neoplasms, Stomach Neoplasms
Food Intake and Gut Hormones in Patients Who Have Undergone Upper Gastrointestinal Surgery for Cancer
Improvements to treatment strategies for patients upper gastrointestinal cancers have produced an increasing population of people who remain free from disease recurrence in the long term.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02385617
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Muscle Weakness
The Effect of GI Biome #7 on Gut Microbiome and Health of the Elderly
This study aims to investigate the effects of probiotics named GI Biome #7 on the gut microbiome and muscle strength in older adults aged 60 years or older.
- Trial name
- NCT05735418
- Testing
- GI Biome #7
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Obesity
The Impact of Sleep Restriction on Gastric Emptying, Appetite and Energy Intake
This study aims to examine if partial sleep deprivation results in alterations blood markers and subjective markers of homeostatic, and hedonic appetite, as well as provide initial data as to the impact of sleep restriction on…
- Trial name
- NCT05953285
- Testing
- Sleep restriction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Overweight and Obesity
SATIN: Satiety Innovation. Study 2- University of Aberdeen
The proposed study will address the effect of developed novel food products through processing innovation on motivation to eat, biomarkers of satiety, nutrient bioavailability and gut health using in vivo studies and validating…
- Trial name
- SATIN (NCT02604316)
- Testing
- Arabinoxylan, Beta- Glucan
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Obesity, Overweight
Metabolic Effect of New Foods Through Gut-brain Axis
A diet high in easily obtained energy-dense foods leads to the problems of overweight and obesity common in the developed world. Foods enriched with fiber or bitter compounds may increase satiety and decrease energy intake.
- Trial name
- CHECKMATE (NCT01851304)
- Testing
- Satiety of breads, Satiety of puddings
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Federico II University
Squamous Cell Carcinoma, Breath Test
Early Diagnosis of Upper Digestive Tract Disease
Upper digestive tract cancer (UDC) is a major disease burden worldwide encompassing all cancers involving the digestive tract (from oral cavity to duodenum).
- Conditions
- Squamous Cell Carcinoma, Breath Test, Digestive System Disease, Diagnose Disease
- Trial name
- E-DIGEST (NCT04475952)
- Where
- United Kingdom
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Irritable Bowel Syndrome
Low-FODMAP Diet and Intestinal Permeability in Patients With Irritable Bowel Syndrome
This study aimed to evaluate the effects of a Low-FODMAP diet on intestinal permeability, symptom severity, and quality of life in patients with Irritable Bowel Syndrome (IBS).
- Trial name
- NCT07467278
- Testing
- low fodmap diet, dietary intervention
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Sebum Production, Stool Microbiome
Pilot Study of Triphala and Rubia Cordifolia on Gut Microbiome and Skin
Few studies have assessed the effects of Triphala and Rubia Cordifolia from a skin biophysical perspective. Here, we aim to understand how these herbs can modulate the skin's barrier properties and the gut microbiome.
- Conditions
- Sebum Production, Stool Microbiome, Transepidermal Water Loss, Facial Brrightness
- Trial name
- NCT03477825
- Testing
- Rubia Cordifolia, Triphala
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pancreatic Cancer
Using Digestive Microbial Information to Enhance the Early Detection of Pancreatic Cancer
Pancreatic cancer (PCA) is a leading death-related cancer. There is an urgent need for accurate, noninvasive diagnostic options in the early detection of pancreatic cancer (PCA), since delayed diagnosis increases the risk of…
- Trial name
- NCT05689138
- Testing
- Oral and Fecal Sample Collection
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Metabolic Syndrome, Anxiety
PRebiotic Intervention for Metabolic and MEntal Health (PRIME)
The purpose of the study is to determine whether a daily prebiotic fibre blend can reduce systemic inflammation, dyslipidemia, and self-report measures of mental health in individuals with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Anxiety, Mood, Stress
- Trial name
- PRIME (NCT06216626)
- Testing
- myota's prebiotic fibre blend
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Myota GmbH
Ulcerative Colitis
Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis
The researchers will investigate gut microbiome in Korean patients with ulcerative colitis and normal control subjects using metagenomic analysis to elucidate the significant difference between two groups This study will help to…
- Trial name
- NCT01010815
- Testing
- Colonoscopy biopsy, stool collection
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Intestinal Inflammation, Metabolic Disease
The Role of Regular Physical Activity in Enhancing Metabolic Health, Reducing Inflammation, and Improving Gut Function
The goal of this clinical trial is to learn if regular physical activity can improve metabolic health, reduce inflammation, and decrease gut permeability in individuals aged 50 and older.
- Trial name
- NCT06606678
- Testing
- Exercise
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Metabolic Disease, Inflammation
Gut Microbiota-dependent Health Impacts of Haskap Berries
Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases.
- Conditions
- Metabolic Disease, Inflammation, Microbial Colonization
- Trial name
- HIH (NCT06546020)
- Testing
- Haskap berry smoothie
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Montana State University
Obesity, Inflammation
Walnut Consumption and Gut Microbiota
Obesity is a growing health issue that effects the majority of adults in the United States. Prevalence of other metabolic diseases are increased in obese adults, including systemic inflammation.
- Trial name
- NCT05441748
- Testing
- Walnuts, Walnut Oil, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Colonization, Asymptomatic, Colonisation
Encapsulated Probiotics & Gut Microbiota
The aim of this study is to determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotics (NCT07439978)
- Testing
- probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
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