Clinical trials: GI Tract Disorders
Rheumatoid Arthritis (RA)
The Effect of the Ideal Food Pyramid on Rheumatoid Arthritis
The aim of this study was to observe the effects of the Ideal Food Pyramid created for Rheumatoid Arthritis patients on disease activity, inflammatory markers, body composition and intestinal microbiota.
- Trial name
- NCT06621927
- Testing
- Diet, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Diabetes Mellitus, Type 2, Obesity
Gut Microbiota, Diet-INDuced Obesity and Type 2 Diabetes in New Caledonia - MIND
In recent years, the global rise in obesity and type 2 diabetes has become a major public health issue. In New Caledonia, 38% of the adult population has a body mass index ≥30.
- Trial name
- MIND (NCT07205913)
- Testing
- 25 ml blood sample, Urine sample, Stools
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Dengue, Dengue Hemorrhagic Fever
Gut Leakage' in Dengue
Dengue infections are imposing an increasing global burden of disease, particularly in tropical countries such as Bangladesh. The World Health Organization (WHO) has identified Dengue virus as a priority pathogen for the…
- Conditions
- Dengue, Dengue Hemorrhagic Fever, Intestinal Disease, Ascites
- Trial name
- GLiD (NCT07602920)
- Where
- Bangladesh
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Glucose Metabolism Disorders
The Anatomical Location, Cellular Origin and Molecular Basis of Gut-derived Glucagon Secretion
Delineation of the anatomical location, cellular origin and molecular basis of gut-derived glucagon secretion
- Trial name
- NCT03181191
- Testing
- Oral glucose tolerance test
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Appetite Regulation
The Effect of Dietary Fibre and Plant Protein on Appetite and Metabolic Function
Acute effects on appetite and metabolic function have been observed for whole-grain rye cereal products. The aim of this study is to evaluate if the appetite suppressing effect of a whole-grain rye breakfast cereal may be further…
- Trial name
- NCT01965210
- Testing
- Rye + high dose inulin + low dose gluten, Rye + equal doses of inulin & gluten, Rye + low dose inulin + high dose gluten
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Obesity
Effect of Probiotics on Regulating Gut Health and Blood Lipid in Adults
The purpose of this study was to evaluate the efficacy of 1 capsules (300 mg per capsule) of Nutrarex Probiotic Capsules per day in regulating gut health and blood lipid in adults by clinical trial.
- Trial name
- NCT06554314
- Testing
- probiotics
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Urinary Tract Infections
Impact of Cranberry Juice Consumption on Gut and Vaginal Microbiota in Post-menopausal Women
This study was a randomized, placebo-controlled, crossover, pilot dietary intervention. Ocean Spray Cranberries, Inc provided the experimental and placebo beverages, which have been validated and used in previous studies [26-29].
- Trial name
- NCT04680325
- Testing
- Juice daily consumption
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Neuroendocrine Neoplasm of Lung, Neuroendocrine Neoplasm of Gastrointestinal Tract (Disorder)
Risk Factors for Neuroendocrine Neoplasms
Recent studies show an increase in neuroendocrine neoplasms, especially for the digestive tract. Previous studies suggest various risk factors that were observed for various tumor sites, e.g.
- Trial name
- NCT06282016
- Testing
- Case-control study (no intervention)
- Where
- Germany
- Volunteers
- 14,250 people, healthy volunteers welcome
- Sponsor
- Bavarian Cancer Registry
Food Allergy
Improvement of Foodallergy Diagnostic in Gastrointestinal Tract
Currently, diagnostic possibilities for the detection of food allergy in the gastrointestinal tract are scarce. The endoscopic segmental Lavage is the method of choice, but it´s controversial.
- Trial name
- NCT03151252
- Testing
- Cytobrush
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Psoriasis
Assessment of Gut Absorption of Experimental Medication BMS-986165 in Healthy Males
The purpose of this study is to evaluate sites of gut absorption of BMS-986165 in males
- Trial name
- NCT03873415
- Testing
- BMS-986165
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cystic Fibrosis
Development Of An Innovative Panel of Methods To Measure Intestinal Macronutrient Digestion, Absorption, and Function
Malnutrition is a significant problem in children and adults with Cystic fibrosis (CF). An impaired intestinal digestion and absorption capacity is one of the main factors responsible for the malnutrition in CF.
- Trial name
- NCT01494909
- Testing
- Ensure plus
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Hypercholesterolemia
Measuring the Impact of Dietary Supplementation With a New Baking Product on Gut Microbiota and Cholesterol Metabolism
Study hypothesis: Diet integrated with food prepared with olive, buckwheat, peas and chestnut flour as in PreBIOil product combination can modify the gut microbiota and the cholesterol metabolism.
- Trial name
- NCT02664428
- Testing
- PreBIOil, Control
- Where
- 2 sites in Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Fondazione Edmund Mach
Depression, Anxiety
Snack Foods and Their Impact on Mental Health and the Gut-brain Axis
The aim of this study is to investigate the effects of snack foods on mental health and the gut-brain axis, in adults with mild to moderate symptoms of depression and anxiety.
- Trial name
- NutriMood (NCT06087471)
- Testing
- Intervention snack, Control Snack
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- King's College London
Graft Rejection, Transplantation
Regenerative Cellular Therapies, Physiology, Pathology and Developmental Biology
This study aims to use tissue from deceased organ donors to investigate organ physiology, developmental biology, as well as the development of future regenerative cellular therapies.
- Conditions
- Graft Rejection, Transplantation, Diabetes Mellitus
- Trial name
- RCT (NCT02469207)
- Testing
- Removal of tissue post-mortem
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Obesity (Disorder)
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro.
- Trial name
- NCT07505212
- Testing
- Gallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prairie View A&M University
eHealth, Dietary Modification
One Year Home Monitoring and Treatment of IBS Patients
The purpose of this study Is to evaluate if a 4 weeks probiotic VSL#3 treatment and a strict LFD for 4 weeks are equally good in treating IBS symptoms in IBS patients with diarrhoea or mixed predominance and further evaluate the…
- Conditions
- eHealth, Dietary Modification, Probiotics, Microbiome
- Trial name
- NCT03586622
- Testing
- Low FODMAP diet (LFD), VSL#3®
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome
Autonomic Reactivity and Personalized Neurostimulation
Disorders of gut-brain interaction (DGBI) affect up to 25% of U.S. children. Patients often suffer from disabling, multisystem comorbidities that suggest a common root (sleep disturbances, fatigue, anxiety, etc).
- Conditions
- Functional Gastrointestinal Disorders (FGIDs), Cyclic Vomiting Syndrome, Functional Dyspepsia, Dysautonomia
- Trial name
- NCT06863207
- Testing
- Percutaneous electrical nerve field stimulation, Hypnotherapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Insulin Sensitivity, 24-hour Glucose Control
Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis
Advancing age is associated with gut dysbiosis, low-grade chronic inflammation, progressive insulin resistance, and increased risk of type 2 diabetes (T2D).
- Trial name
- NCT05358171
- Testing
- HIgh UPF controlled diet, No UPF controlled diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Allergic Disorder, Food Hypersensitivity
Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age…
- Conditions
- Allergic Disorder, Food Hypersensitivity, Food Allergy in Children
- Trial name
- NCT05442658
- Testing
- Microbiota
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
PreDiabetes, Insulin Sensitivity
Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese
Overweight/obese Chinese and prediabetes will be recruited and divided into three age-matched groups including high intensity exercise, moderate intensity exercise, and non-exercise groups.
- Trial name
- NCT03240978
- Testing
- exercise intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
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