Clinical trials: GI Tract Disorders
Gut Dysbiosis for TMAO Production From L-carnitine Consumption
Using Gut Microbial Gbu Gene Testing to Estimate Host TMAO Production Capacity
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to TMAO in the body by certain bacteria.
- Trial name
- NCT05980884
- Testing
- L-carnitine
- Where
- Taiwan
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastric Cancer, Precancerous Lesion of Digestive Tract
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution.
- Conditions
- Gastric Cancer, Precancerous Lesion of Digestive Tract, Extrachromosomal DNA
- Trial name
- NCT05956847
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Severe Traumatic Brain Injury
The Systemic Nature of Severe Traumatic Brain Injury
Severe traumatic brain injury (sTBI) is a devastating condition with no targeted therapies available to prevent secondary injury.
- Trial name
- MANTRA (NCT07679126)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Corewell Health West
Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria.
- Conditions
- Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection
- Trial name
- AB-care (NCT06919068)
- Testing
- Colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Major Depressive Disorder, Bipolar Disorder, Mixed
Chinese Longitudinal and Systematic Study of Bioplar Disorder
Affective disorders (mainly including major depressive disorder and bipolar disorder) are common, chronic and highly disabling mental disorders, which lack of objective biological markers.
- Conditions
- Major Depressive Disorder, Bipolar Disorder, Mixed, Affective; Disorder, Organic
- Trial name
- CLASS-BD (NCT05480150)
- Testing
- Escitalopram Oxalate Tablets, Quetiapine Fumarate Tablets, Lurasidone
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Eating Behavior, Obesity
Effect of Gut-Cued Eating on BMI and Efficacy of Open-Label Placebo to Augment Weight Loss
The study will assess the effect of attending to stomach-cues of hunger and fullness on body weight and any additional benefit provided by open-label placebo.
- Conditions
- Eating Behavior, Obesity, Body Weight, Hunger
- Trial name
- GCE (NCT03850990)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Major Depression, Functional Dyspepsia
The Brain-Heart-Gut Connection
Major Depressive Disorder (MDD) often co-occurs with cardiovascular and gastrointestinal symptoms, highlighting the importance of the brain-heart-gut connection in developing comprehensive treatments.
- Conditions
- Major Depression, Functional Dyspepsia, Autonomous Dysfunction
- Trial name
- BHG-CONNECT (NCT06748274)
- Testing
- Transcranial Magnetic Stimulation (TMS), High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- Switzerland
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bern
Infant Colic, Atopic Dermatitis
Use of Bifidobacterium Bifidum in Formula-Fed Infants With Colic, With or Without Atopic Dermatitis
The goal of this clinical trial is to evaluate whether daily probiotic supplementation with Bifidobacterium bifidum (Bifipral® drops) can reduce crying time in formula-fed infants aged 5 months or younger diagnosed with infant…
- Trial name
- NCT07754968
- Testing
- Bifidobacterium bifidum BFP19® and BFP29® (Bifipral®)
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Kidney Calculi, Ureteral Calculi
Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1.
- Trial name
- NCT07043374
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Microbial Colonization, Antibiotic Side Effect
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome.
- Conditions
- Microbial Colonization, Antibiotic Side Effect, Cesarean Section Complications
- Trial name
- CSBabyBiome (NCT06030713)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Gut Inflammation, Overweight and Obese Volunteers
Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.
Inflammatory bowel disease (IBD) affects over 6.8 million people worldwide, with current treatments often causing side effects and poor patient compliance.
- Trial name
- NCT07253155
- Testing
- Probiotic Arm
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Obesity
Direct Measurement of Ingestive Behaviour in Relation to Sex Differences and Gastrointestinal Hormone Levels in Patients After Metabolic and Bariatric Surgery
Bariatric surgery (BS), especially procedures like Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), is the most effective treatment for obesity.
- Trial name
- DIBASH (NCT06538948)
- Testing
- Bariatric Surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity
Weight-loss and Gut-brain Interactions
While exposure to an obesogenic environment has increased for almost every individual in western society, not everyone is equally susceptible to overeating and not everyone becomes obese.
- Trial name
- NCT01740050
- Testing
- Very Low Calorie Diet (VLCD), RYGB, LAGB
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Chronic Kidney Diseases
Impact of Dapagliflozin on Intestinal Microbiota Composition and on the Metabolites Derived From the Intestinal Microbiota in Non-diabetic Chronic Renal Failure Patients
Chronic kidney disease (CKD) is a common disease affecting 10-12% of the adult population and characterize with high-risk cardiovascular morbidity and mortality with progression of CKD.
- Trial name
- DAPA-GUT (NCT05965440)
- Testing
- impact of Dapagliflozin on Intestinal Microbiota on chronic renal failure patients
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Apnea, Sleep
Effects of CPAP on Cognitive Function, Neurocognitive Architecture and Function in Patients With OSA: The SMOSAT Trial
Multiple clinical studies have indicated that obstructive sleep apnea (OSA), the most common chronic sleep disorder, may affect neurocognitive function, and that treatment for continuous positive airway pressure (CPAP) has some…
- Trial name
- NCT02886156
- Testing
- CPAP, BSC
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Obesity, Overweight
Effect of Food Temperature and Diet Composition on Satiety, Satiety Hormones, Chewing Time and Neuronal Activity
Obesity and its related illnesses have become serious health issues, obesity is today the fifth most common cause of death. Obesity rate has dramatically enhanced in both male and female, and across all ages.
- Trial name
- NCT05822167
- Testing
- High Protein Meal at Cold Temperature, High Protein Meal at Warm Temperarute, High Protein Meal at Hot Temperature
- Where
- Pakistan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
Stomach Diseases, Small Intestine Disease
Magnetically Controlled Capsule Endoscopy in Visualization of the UGI and Small Intestine
In this study, we retrospectively analyzed the videos of combined upper digestive tract and small intestine examination under MCE, so as to clarify the feasibility and diagnostic efficacy of MCE in one-time examination of the…
- Trial name
- NCT05069233
- Testing
- UGI+SB
- Where
- China
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
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