Clinical trials: GI Tract Disorders
Esophageal Cancer
Perioperative SDD to Prevent Infectious Complications After Esophagectomy
The primary aim of the PERSuaDER-trial is to evaluate the effect of SDD on infectious complications after esophagectomy, focussed on the prevention of pneumonia
- Trial name
- PERSuaDER (NCT05865743)
- Testing
- SDD
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 854 people
- Sponsor
- Radboud University Medical Center
Colon Cancer, Head and Neck Cancer
Assessing the Value of a Dosage of Anti-cetuximab in the Therapeutic Management of Patients With Colon Cancer or Upper Aero-digestive Tract and Candidates for Treatment With Cetuximab
The main objective of this study is to validate the utility of IgE anti-cetuximab in the treatment strategy to identify patients at risk for a severe allergic reaction to cetuximab (grade 3 or 4 of the classification of NCI) and…
- Conditions
- Colon Cancer, Head and Neck Cancer, Allergic Reaction
- Trial name
- IgES (NCT01436617)
- Testing
- blood sample
- Where
- 10 sites in France
- Volunteers
- 303 people
- Sponsor
- Centre Francois Baclesse
Obesity
The Incretin Secretion in the Gut System Related to the Physiological Stimulus
Insulin secretion and insulin sensitivity are related with an inverse, hyperbolic function, the so called disposition index, that shows the critical importance of the ß-cell dysfunction for the development of T2DM.
- Trial name
- NCT00994435
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Catholic University of the Sacred Heart
HIV Infections
Four-Drug Combination Therapy With Zidovudine, Lamivudine, 1592U89 (Abacavir), and 141W94 (Amprenavir) in HIV-Infected Patients
The purpose of this study is to see if the multidrug combination of zidovudine (ZDV), lamivudine (3TC), 1592U89 (abacavir [ABC]), and 141W94 (amprenavir [APV]) is a safe and effective treatment for HIV-infected patients and if…
- Trial name
- NCT00006617
- Testing
- Abacavir sulfate, Amprenavir, Lamivudine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Type 2 Diabetes
The Interaction Between Protein Intake, Gut Microbiota and Type 2 Diabetes in Subjects With Different Ethnic Backgrounds
Context and justification: There is growing evidence that the gut microbiota is a key element in the pathophysiology of cardio-metabolic diseases (CMD) such as Type 2 Diabetes (T2D).
- Trial name
- MICRODIET (NCT03732690)
- Testing
- Diet HP, Diet LP
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gestational Diabetes Mellitus in Childbirth, Neurodevelopmental Disorders
Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
The prospective multicenter study GD-Brain provides a better knowledge on the basis of neurological impairment in children born to mothers with gestational diabetes (GDM).
- Trial name
- GD-BRAIN (NCT03032991)
- Where
- Spain
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Change in Fasting Plasma LDL-cholesterol Concentration After the Consumption of Quinoa
Effects of Quinoa Consumption on Markers of Cardiovascular Risk and Gastrointestinal Health
Quinoa is possible alternative to wheat, corn and rice due to its high nutritional value and possible properties against cardiovascular diseases and for improving gut health.
- Trial name
- NCT03036618
- Testing
- Quinoa, Wheat
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Pancreatic Cancer, Gastrointestinal Neoplasms
Permission to Collect Blood Over Time for Research
To determine whether biomarkers assessed in blood samples can be used to detect individuals at risk for developing blood clots or worsening of their underlying disease.
- Conditions
- Pancreatic Cancer, Gastrointestinal Neoplasms, Colon Rectal Cancer Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00767234
- Testing
- Observation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation
Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus
This study aims to investigate the effects of intensive medical nutrition therapy on blood sugar control, systemic inflammation, and gut barrier function in adults with type 2 diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation, Intestinal Permeability, Glycemic Control
- Trial name
- NCT07037212
- Testing
- Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Serap Balaban Barta
Postoperative Ileus
The Effect of Rocking Chair Movement on the Start of Bowel Functions in Patients With Gastrointestinal System Surgery
The Effect of Rocking Chair Movement on the Start of Bowel Functions in Patients With Gastrointestinal System Surgery The research will be carried out as a randomized controlled experimental study in patients with open…
- Trial name
- NCT04466319
- Testing
- Rocking Chair
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Eskisehir Osmangazi University
Bladder and Bowel Dysfunction
Bladder and Bowel Dysfunction in Children
Background: Bladder and bowel dysfunction (BBD) is characterized by lower urinary tract symptoms accompanied by bowel complaints. BBD is a common condition in childhood.
- Trial name
- NCT05318365
- Testing
- Polyethylene Glycol 3350, Urotherapy
- Where
- 3 sites in Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Attention Deficit-Hyperactivity Disorder
Biomarker Research in ADHD: the Impact of Nutrition
Attention deficit hyperactivity disorder (ADHD) is the most common childhood behavioural disorder, causing significant impediment to a child's development. The exact aetiology of ADHD is still unknown.
- Trial name
- BRAIN (NCT03440346)
- Testing
- Few-foods diet
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Wageningen University
Colorectal Cancer
Microbiome-based Diagnostic Tool for the Screening of Colorectal Cancer (GUILTI)
Colorectal cancer (CRC) is one of the most common cancer and cause of cancer death worldwide. Population-based screening programs for average risk populations have proven effective in reducing both incidence and mortality of CRC…
- Trial name
- GUILTI (NCT06738173)
- Testing
- Gut microbiome testing
- Where
- Italy
- Volunteers
- 1,202 people
- Sponsor
- Catholic University of the Sacred Heart
Inflammatory Bowel Diseases, Mild Cognitive Impairment
Cognitive Impairment and Affective Mood Disorders in Patients With IBD
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests.
- Conditions
- Inflammatory Bowel Diseases, Mild Cognitive Impairment, Depression, Anxiety
- Trial name
- COGN-IBD-1 (NCT05760729)
- Testing
- Cognitive testing
- Where
- 3 sites in Romania
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Depression, Anxiety Disorder
Effect of Lactobacillus Plantarum 299v Supplementation on Major Depression Treatment
The aim of the study is to determine the influence of supplementation of probiotic Lactobacillus Plantarum 299V vs. placebo of probiotic during antidepressant monotherapy with SSRI (Selective Serotonin Reuptake Inhibitor) in…
- Trial name
- NCT02469545
- Testing
- Lactobacillus Plantarum 299v, Crystalline cellulose powder, Escitalopram
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
REM Sleep Behavior Disorder
Gut Microbiota in the Progression of Alpha-synucleinopathies
The aim of this study is to correlate baseline gut microbiota features and the progression of neurodegeneration in the established cohort of patients with early Parkinson's disease.
- Trial name
- NCT05353868
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 490 people
- Sponsor
- Chinese University of Hong Kong
Sarcopenia
The Characteristics of Gut Microbiota in Patients With Sarcopenia and the Development of Probiotics
The primary aim of this study is to identify the composition and characteristics of the gut microbiota in patients with sarcopenia in older adults, and compare these with the gut microbiota characteristics of older adults and…
- Trial name
- NCT07334210
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Vitamin A Deficiency
Vitamin A, Stool Microbiota and Vaccine Response in Bangladeshi Infants
Vitamin A deficiency (VAD) increases the risk of death from infections in infants and young children. The World Health Organization (WHO) recommends high-dose vitamin A supplementation (VAS) from 6-59 months of age to reduce the…
- Trial name
- NCT02027610
- Where
- 3 sites in United States, Bangladesh
- Volunteers
- 258 people
- Sponsor
- USDA, Western Human Nutrition Research Center
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