Clinical trials: GI Tract Disorders
Childhood Obesity
Effect of POSTbiotics Supplementation on Microbiome in OBese Children: the POST-OB Study
This study evaluates the possible effect of postbiotics supplementation, combined with interventions aimed at improving diet and lifestyle, on gut microbiota composition and metabolite production.
- Trial name
- POST-OB (NCT04151823)
- Testing
- Vitamin D3, Immunofos, Promotion of physical activity
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan
Glucose Intolerance, Obesity
Effect of a Low-carb Dietary Intervention in Obese Patients: a Pilot Trial
Effects of a 6 months low-carb dietary intervention on glycemic control, body composition and gut-brain interaction in obese and lean patients with and without glucose intolerance or diabetes
- Trial name
- NCT04234373
- Testing
- Low Carb diet
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Lisdexamphetamine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03497169
- Testing
- Lisdexamfetamine Dimesylate
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Insulin Sensitivity, Overweight or Obesity
Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
Objective 1: Characterize indices of systemic inflammation and gut microbiota composition and function after chronic (12 weeks) intake of pulses compared to control diet in human OW/OB-IR participants.
- Conditions
- Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
- Trial name
- PS (NCT04267705)
- Testing
- Control, Black bean, Chickpea
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
General Population (no Specific Condition or Disease)
Evaluation of Reminder Strategies (Emails and Text Messages) to Increase Participation in the Le French Gut E-cohort
This study is a randomized controlled trial nested in the "Le French Gut" e-cohort aiming to test the efficacy of 4 reminder strategies (emails and/or SMS with standard and/or institutional wording) in increasing participation of…
- Trial name
- NCT07473466
- Testing
- 3 standard email reminders, 3 institutional email reminders, 3 SMS reminders
- Where
- France
- Volunteers
- 20,487 people, healthy volunteers welcome
- Sponsor
- SKEZI
Overweight
Effect of Weizmania Coagulans BC99 Intervention on Gut Microbiota and Metabolic Markers in Overweight/Obese Adults
The main purpose of this study is to verify the effects of Weizmania Coagulans BC99 on the gut microbiota and fat related markers (TG, TC, HDL, LDL) in overweight/Obese adult subjects.
- Trial name
- NCT06077383
- Testing
- Weizmania Coagulans BC99
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Qilu Hospital of Shandong University
Parkinson's Disease Aggravated
Microbiota Modification for the Treatment of Motor Complication of Parkinson´s Disease
In recent years, abnormalities in gut microbiota have been identified in patients with Parkinson´s disease having a possible role in motor manifestations.
- Trial name
- NCT04730245
- Testing
- sodium phosphate enema, oral rifaximin and polyethylene glycol
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Torre Médica Santé
Depression, Anxiety
The Correlation Characteristics Between Mental Health and Gut Microbiota of College Students in Qingyuan Vocational Education City
The goal of this observational study is to learn about the mental health status and gut microbiota characteristics of college students in Qingyuan Vocational Education City.
- Trial name
- NCT06595095
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Intestinal Diseases, Helminthiasis
Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut Microflora
Albendazole is a main anti-helminth, however there is a lack of data regarding its efficacy in the school children population. The aim of this study is to evaluate the efficacy of the albendazole one versus two and three doses…
- Trial name
- NCT01192802
- Testing
- albendazole
- Where
- Gabon
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Albert Schweitzer Hospital
Rett Syndrome, Dysbiosis
Protective Role of Pre-/ Post-biotics on Gut Inflammation, Dysbiosis, and Life Quality in Rett Syndrome (Biotics_RTT)
The study will examine the potential efficacy and safety of two pre- and post-biotics on markers for gut inflammation and intestinal microbiota ecology in patients with Rett syndrome.
- Conditions
- Rett Syndrome, Dysbiosis, Epilepsy, Quality of Life
- Trial name
- Biotics_RTT (NCT05420805)
- Testing
- ALAC, inulin, FOS, and sodium butyrate, Sodium butyrate and zinc oxide
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Microbial Colonization
Investigating the Impact of Humiome B2 (Colon Delivered Riboflavin) and Riboflavin-overproducer Probiotic Strain Limosilactobacillus Reuteri AMBV339 on Intestinal and Vaginal Microbiome and Health of Healthy Adult Women (The VIAB2L Project)
The goal of this clinical trial is to learn if the probiotic strain Limosilactobacillus reuteri AMBV339 or colon-delivered riboflavin or their combination can change the gut and vaginal microbiome and metabolomics.
- Trial name
- VIAB2L (NCT06425081)
- Testing
- Limosilactobacillus reuteri AMBV339, Humiome B2, Limosilactobacillus reuteri AMBV339 + Humiome B2
- Where
- Belgium
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Gastrointestinal Disease, Inflammatory Bowel Disease (IBD)
Elemental 028 Extra Case Studies
Elemental 028 Extra is a nutritionally complete ACBS approved amino acid-based (elemental) feed designed to provide adequate daily amounts of both macronutrients and micronutrients when used as a sole source of nutrition and to…
- Conditions
- Gastrointestinal Disease, Inflammatory Bowel Disease (IBD), Short Bowel, Malabsorption
- Trial name
- E028E (NCT06877923)
- Testing
- Elemental 028 Extra
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nutricia UK Ltd
Crohn Disease
Can Intermittent Fasting Induce Weight Loss and Improve Gut Health as Compared to Standard Medical Care in Patients With Obesity/High BMI and Crohn's Disease.
Diet is a determinant of gut microbial diversity and composition and is recognized as a potential environmental trigger for IBD; for example, high-fat diets are associated with increased risk of CD in pre-clinical models, with…
- Trial name
- CD-Fast (NCT05230160)
- Testing
- Intermittent Fasting
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Esophagogastroduodenoscopy
AQCS for Detection of Early Cancer and Precancerous Lesions on Upper Gastrointestinal Tract
The purpose of our study was to assess the performance of esophagogastroduodenoscopy automatic quality-control system in real-time quality control of EGD.
- Trial name
- NCT04720924
- Testing
- Computer-aided Real-time Automatic Quality-control System
- Where
- 6 sites in China
- Volunteers
- 1,840 people
- Sponsor
- Shandong University
Parkinson Disease, Genetic Predisposition
Study of the Genome, Gut Metagenome and Diet of Patients With Incident Parkinson's Disease
A case-control study to identify microbiome and genetic differences between healthy subjects and patients with incident Parkinson's disease.
- Trial name
- NCT04119596
- Testing
- 16S rRNA gene sequencing, DNA-microarray genotyping
- Where
- Russia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Atlas Biomed
Healthy
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite…
- Trial name
- AFC-SPICES (NCT02035241)
- Testing
- Spices 1, Spices 2, Spices 3
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity, Insulin Resistance
Fiber and Insulin Sensitivity
Based on previous research of the investigators group, the investigators hypothesize that slowly fermentable fibers with a high degree of polymerization that increase SCFA specifically in the distal colon are expected to have…
- Trial name
- NCT04714944
- Testing
- Whole fiber product
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Hypercholesterolemia
Red Yeast Rice for Primary Prevention of Hypercholesterolemia
This two-year observational study will be conducted at the outpatient clinic of the Department of Traditional Chinese Medicine of Taoyuan Chang Gung Hospital from February 26, 2024 to December 31, 2025.
- Trial name
- NCT06301906
- Testing
- LipoCol Forte Capsule 600mg twice a day
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Chang Gung Memorial Hospital
Pneumonia, Urinary Tract Infections
Prehospital Assessment Units - a Matched Cohort Study
This study aimed to evaluate the prehospital assessment unit (PAU) by admission within 48 hours, 7 days, respectively and on survival.
- Conditions
- Pneumonia, Urinary Tract Infections, Fall, Infections
- Trial name
- NCT05654909
- Testing
- Prehospital assessment unit
- Where
- Denmark
- Volunteers
- 10,849 people
- Sponsor
- Prehospital Center, Region Zealand
Hepatocellular Carcinoma, Liver Cancer
Gut Microbiota in People With Hepatocellular Carcinoma (HCC)
Background: There are about 100 trillion microbial cells in a person s gut. This is called the human gut microbiota. When this is disrupted, it can lead to many diseases.
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, Liver Cell Caricinoma, Liver Neoplasm
- Trial name
- NCT02599909
- Sponsor
- National Cancer Institute (NCI)
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