Clinical trials: GI Tract Disorders
Non-Small Cell Lung Carcinoma, Breast Cancer
A Study of V934/V935 Vaccine in Cancer Participants With Selected Solid Tumors (V934-002)
This is a two-part study to test the safety, tolerability, and immune response for V934/V935 vaccine using a new prime-boost regimen in participants with selected solid tumors.
- Conditions
- Non-Small Cell Lung Carcinoma, Breast Cancer, Melanoma, Upper GI Tract Carcinoma
- Trial name
- NCT00753415
- Testing
- V935, V934-EP
- Volunteers
- 37 people
- Sponsor
- Merck Sharp & Dohme LLC
Probiotics
Use of a Selected Mixture of Probiotic Strains for Degrading Gluten During Digestion
Gluten intake spreads worldwide, being the major food protein consumed in the Western diets (up to 20 g gluten/d). But gluten has unique and unusual features.
- Trial name
- NCT05798689
- Testing
- Probiotic administration and gluten
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Free University of Bozen-Bolzano
Inflammatory Bowel Diseases
Virtual Reality (VR) -Directed Brain Gut Behavioral Treatment (BGBT) for Inflammatory Bowel Disease (IBD) Inpatients
The research is studying virtual reality (VR)-directed brain-gut behavioral therapy (BGBT) as a pain treatment option for hospitalized patients with inflammatory bowel disease (IBD).
- Trial name
- NCT06188793
- Testing
- Virtual reality-directed BGBT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Short Bowel Syndrome, Short Gut Syndrome
A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Investigational Product MP-101 in Subjects With Short Bowel Syndrome Who Have Had an Inadequate Response to Anti-Diarrheals
MP-101 will be evaluated in this study to see if it is safe, tolerable, and can help people with Short Bowel Syndrome. This study will also find out if taking MP-101 can improve the symptoms of Short Bowel Syndrome and reduce the…
- Conditions
- Short Bowel Syndrome, Short Gut Syndrome, SBS, Short Bowel
- Trial name
- NCT02242656
- Testing
- Opium Tincture USP Deodorized
- Where
- 5 sites in United States
- Sponsor
- Marathon Pharmaceuticals, LLC
Anal Cancer, Colorectal Cancer
Assessment of Symptom-Related Cytokines in Lung and Gastrointestinal (GI) Cancer Patients
Primary Objectives: To determine the feasibility of a study that would describe changes of certain circulating inflammatory cytokines (interleukin-1, 6, 8, 10, 12, and tumor necrosis factor-alpha [TNF] and symptoms related to…
- Conditions
- Anal Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00502502
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- M.D. Anderson Cancer Center
Inflammatory Bowel Diseases, Clostridium Difficile Infections
Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients
The goal of this research is to compare alterations of gut microbiota and fecal metabolomics alterations between inflammatory bowel disease patients infected with or without Clostridioides difficile.
- Conditions
- Inflammatory Bowel Diseases, Clostridium Difficile Infections, Microtia
- Trial name
- NCT05714566
- Testing
- Clostridioides difficile toxin detection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Type 1 Diabetes, Hypoglycemia
Neuronostatin - a Glucagonotropic Agent in Humans?
With the present study the investigators wish to delineate the effects of neuronostatin-13 (NST) on glucose-dependent glucagon secretion in humans.
- Conditions
- Type 1 Diabetes, Hypoglycemia, Type1diabetes
- Trial name
- NSTCLAMP (NCT06143267)
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Ulcerative Colitis
Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
Probiotics are one of the adjunctive treatments that have been extensively explored for Ulcerative colitis (UC) disease management.
- Trial name
- NCT06595719
- Testing
- Multi-Strain Probiotics
- Where
- Malaysia
- Volunteers
- 124 people
- Sponsor
- National University of Malaysia
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
DGBI, Depression/Anxiety
Feasibility and Acceptability of an Online ACT Intervention for Disorders of Gut-Brain Interaction - Beta Trial
The goal of this clinical trial is to assess the acceptability, feasibility, and usability of the iACTforDGBI intervention among patients with Disorders of Gut-Brain Interaction (DGBI).
- Trial name
- iACTforDGBI (NCT07175402)
- Testing
- Acceptance and Commitment Therapy (ACT), Psychoeducation
- Where
- Sweden
- Volunteers
- 27 people
- Sponsor
- Örebro University, Sweden
Irritable Bowel Syndrome
Influence of Ear Vagus Nerve Stimulator on Patients With IBS
Irritable bowel syndrome (IBS) is a very common functional digestive disorder characterized by chronic abdominal pain and altered bowel habits in the absence of biological or structural abnormalities.
- Trial name
- NCT06321237
- Testing
- Vagus nerve stimulation for 8 weeks, Vagus nerve stimulation for the first 4 weeks, Vagus nerve stimulation for the last 4 weeks
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huaping Xie
Celiac Disease
Impact of a Low-FODMAP Gluten-free Diet on Gut Microbiota and Circulating miRNAs in Celiac Disease Patients
15 patients with refractory celiac disease (RCD) and 15 patients with CD responsive to the GFD between the ages of 21 and 60 will be enrolled.
- Trial name
- FODMAP2019 (NCT04655495)
- Testing
- Low FODMAPs /balanced gluten free diet
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Obesity & Overweight, Perimenopausal Women
Prebiotic Inulin for Late-Reproductive Individuals
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1.
- Conditions
- Obesity & Overweight, Perimenopausal Women, Prebiotics, Inulin
- Trial name
- PILI (NCT07724522)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- George Washington University
Healthy, Obesity
Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students
The main medical and social purpose of the project "It's trendy to be healthy!" is the promotion of healthy lifestyles and healthy eating among student youth.
- Conditions
- Healthy, Obesity, Nutrition, Healthy, Vitamin D Deficiency
- Trial name
- NCT05073029
- Testing
- nutrition program and modification of physical activity, synbiotic (Fructooligosaccharides+Lactobacillus rhamnosus GG ATCC 53103, 4.0х109 colony forming units - CFU), vitamin D3
- Where
- 2 sites in Ukraine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
H.Pylori Gastrointestinal Disease
Second Line Bismuth Containing Quadruple Therapy With Supplementary Probiotic
This study is designed to evaluate the clinical outcome of second line Bismuth containing quadruple therapy with supplementary probiotic for Helicobacter pylori eradication
- Trial name
- NCT05577572
- Testing
- Probiotics packets
- Where
- 4 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Ulcerative Colitis
Dynamic Changes of Gut Microbiota in UC After FMT
A prospective study to investigate the dynamic changes of gut microbiota through colonic transendoscopic enteral tubing in patients with ulcerative colitis after fecal microbiota transplantation.
- Trial name
- NCT03949257
- Testing
- colonic transendoscopic enteral tubing
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Colonic Cancer
Aquamin and Prevention of Colon Cancer
In the proposed study, investigators will conduct a 90-day dietary intervention study in human subjects. Thirty individuals at risk for adenomatous colon polyp formation will be randomized to receive a calcium and…
- Trial name
- NCT02647671
- Testing
- Aquamin®, Calcium Carbonate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- James Varani
Autism Spectrum Disorder
Randomized Double-blind Clinical Trial With L.Reuteri Supplementation in Children With Autism Spectrum Disorder
The aim of this study is to assess the effects of a 6-months probiotic supplementation on behavioral profiles, microbiota and metabolic profiles, inflammatory biomarkers, gastrointestinal disturbances, in children with Autism…
- Trial name
- NCT04293783
- Testing
- L.Reuteri
- Where
- 2 sites in Italy
- Volunteers
- 43 people
- Sponsor
- University of Rome Tor Vergata
Obesity
A Pilot Trial of Nabilone for the Treatment of Obesity
Obesity is a serious health problem which increases the likelihood of developing other life-changing medical conditions. Despite increasing knowledge about the neural and metabolic basis of obesity, the development of effective…
- Trial name
- NCT04801641
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Dyspepsia, Functioanl Dyspepsia
Effect of Digestive Enzymes as Add on Therapy on Patients With Functional Dyspepsia.
The goal of this clinical trial is to assess the effect of digestive enzymes in improving dyspeptic symptoms in patients with functional dyspepsia.
- Conditions
- Dyspepsia, Functioanl Dyspepsia, Epigastric Pain Syndrome, Epigastric Fullness
- Trial name
- NCT07578402
- Testing
- Digestive enzyme 325mg, PPI 20 mg + Domperidone 10 mg
- Where
- Bangladesh
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rakibul Mostafa
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