Clinical trials: GI Tract Disorders
Gastroesophageal Reflux
MSG and Gastrointestinal Motility
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Trial name
- NCT01009658
- Testing
- Monosodium glutamate, Sodium chloride
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gunma University
Colorectal Cancer, Diet Habit
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
A Mediterranean Diet (MedDiet), a largely plant-based dietary pattern, is relevant to CRC prevention and microbial production of anti-cancer metabolites in observational studies.
- Trial name
- Bridge CRC (NCT04753359)
- Testing
- Med, WL
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer
This trial studies the role of the gut microbiome and effectiveness of a fecal transplant on medication-induced gastrointestinal (GI) complications in patients with melanoma or genitourinary cancer.
- Conditions
- Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8, Clinical Stage IA Cutaneous Melanoma AJCC v8, Clinical Stage IB Cutaneous Melanoma AJCC v8
- Trial name
- NCT03819296
- Testing
- Best Practice, Biospecimen Collection, Endoscopic Procedure
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- M.D. Anderson Cancer Center
Malnutrition, Pressure Ulcer
Pressure Ulcers in Patients Receiving Enteral Nutrition Therapy and Their Relationship With Gut Microbiota
Participants will be randomly assigned to the experimental group where they will be given enteral nutrition formula rich in zinc and arginine plus a symbiotic (Probinul- Ca.Di.GROUP S.r.l.) once a day for 90 days or the control…
- Trial name
- NCT03627910
- Testing
- symbiotic, zinc and arginine
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Radiomics, Multi-omics
Neurophenotype Predicts CD Disease Progression
The goal of this observational study is aimed to develop a novel multimodal neuroimaging-based model to characterize the neurophenotype of Crohn's Disease patients and assess its ability for predicting disease progression, using…
- Trial name
- NCT06452550
- Testing
- Logistic regression (LR) prediction models
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Amlodipine
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT02904291
- Testing
- Amlodipine
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Healthy Subjects
On the Impact of Common Sweetening Agents on Glucose Regulation, Cognitive Functioning and Gut Microbiota
The study intention is to investigate, in healthy humans, effects of 3 commonly used sweeteners on cardiometabolic risk markers, cognitive functions, and influences on gut microbiota composition.
- Trial name
- NCT02580110
- Testing
- Sucrose, Stevia glycosides, saccharin
- Where
- Sweden
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Lund University
Cognitive Decline, Mild
Cognition, Flavonoids, Exercise, Gut Microbiome
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants…
- Trial name
- NCT06495190
- Testing
- Blueberry, Walking, Stretching
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Hypoparathyroidism
Effects of a Liquid Meal and Gut Hormones (GIP and GLP-2) on Bone Remodeling in Participants With Hypoparathyroidism.
Hypoparathyroidism (hypoPT) is characterized by low levels of PTH. In this study we will test the effects of a liquid meal on the bone remodeling in participants with hypoparathyroidism.
- Trial name
- KS-4-HypoPT (NCT03728959)
- Testing
- Liquid meal (Nutridrink), GIP, GLP-2
- Where
- Denmark
- Volunteers
- 7 people
- Sponsor
- University of Copenhagen
Kidney Failure, Chronic
The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)
The purpose of this study is to investigate the differences of gut Microbiome/Metabolite between ESRD patients and healthy subjects.
- Trial name
- NCT03010696
- Testing
- No interventions, questionnaire, collect specimen
- Where
- 4 sites in China
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- China Agricultural University
Crohn's Disease, Inflammatory Bowel Diseases
Beta-Hydroxybutyrate Feasibility Treating IBD
This clinical trial aims to understand the feasibility of patients taking ketone body supplement beta-hydroxybutyrate (BHB) for 4 weeks with a confirmed diagnosis of Crohn's disease and starting new therapy for active disease.
- Trial name
- BHB (NCT06351124)
- Testing
- Feasibility of beta-hydroxybutyrate supplementation to reduce inflammation in patients with Crohn's
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas at Austin
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Breast Cancer
Gut Microbiome Components Predict Response to Neoadjuvant Therapy in HER2-positive Breast Cancer Patients : A Prospective Study
In this study the characteristics and alterations of the gut microbiome during neoadjuvant therapy for HER2-positive breast cancer patients are studied, as well as the relation between the gut microbiome and probability of pCR.
- Trial name
- NCT05444647
- Testing
- stool and blood collection
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Obesity, Morbid
Bariatric Surgery and Pharmacokinetics of Chlorprothixene
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines.
- Trial name
- NCT03449485
- Testing
- Chlorprothixene
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- Norwegian University of Science and Technology
Parkinson Disease
Impact of C-Mill Rehabilitation on the Gut-Brain Axis in Parkinson's Disease
The GM-REHAB-2025 study aims to evaluate the impact of physiotherapy interventions using the C-Mill treadmill, with and without semi-immersive virtual reality, on gut microbiota and metabolic parameters in patients with…
- Trial name
- NCT07434089
- Testing
- C-Mill technology treadmill equipped with semi-immersive VR, C-Mill treatment without semi-immersive virtual reality (VR), Conventional physiotherapy training
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Ulcerative Colitis (UC)
Seaweed Extract (Fucoidan) for Gut Inflammation in Ulcerative Colitis
What is the research question being addressed? Does combining Turbinaria ornata-derived fucoidan with standard therapy lead to a significantly higher rate of gut health restoration-defined by increased fecal short-chain fatty…
- Trial name
- SEA-GUT (NCT07786389)
- Testing
- Low molecular weight fucoidan and standard care
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Allama Iqbal Medical College
Breast Cancer, Adjuvant Chemotherapy
Relationship Between Gut Microbiome and Adjuvant Chemotherapy in Patients With Early Breast Cancer
Breast cancer is the most common cause of cancer death in women. Adjuvant chemotherapy significantly reduces the risk of recurrence of high-risk breast cancer.
- Trial name
- NCT03702868
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Sun Yat-sen University
Nutrition
Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease
The purpose of this study is to see if intestinal bacteria plays a role in choline metabolism (a form of choline monitored in this study is called phosphatidylcholine, also known as lecithin).
- Trial name
- Glory (NCT01519310)
- Testing
- Antibiotic (metronidazole and ciprofloxacin)/probiotic
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Diabetes Mellitus, Type 2
Effect of Metformin on Gut Peptides , Bile Acids and Lipid Profiles in Type 2 Diabetics
Metformin is a biguanide that is marketed as an oral anti-diabetic drug. Metformin treatment in concert with diet and exercise is the consensus first-line treatment for type 2 diabetes mellitus (T2DM), and therefore it will…
- Trial name
- NCT01357876
- Testing
- Metformin
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
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