Clinical trials: GI Tract Disorders
Autism Spectrum Disorder
Efficacy of Vivomixx on Behaviour and Gut Function in Autism Spectrum Disorder
The purpose of this study is to assess the effects of 3 months supplementation with the multi strain probiotic Vivomixx on the overall function, aberrant behaviours and frequency of gastrointestinal symptoms in children with…
- Trial name
- VIVO-ASD (NCT03369431)
- Testing
- Vivomixx
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University College, London
Gastro Intestinal Bleeding, Ischaemic Heart Diseases
Gastrointestinal Bleeding is Blood Loss in the Digestive Tract, Classified as Upper or Lower. Ischemic Heart Disease is Due to Blocked Heart Arteries. Antiplatelet Drugs Help Prevent Heart Attacks But Increase GI Bleeding Risk, Especially When Used Together as Dual Therapy.
Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries.
- Conditions
- Gastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
- Trial name
- NCT07125651
- Volunteers
- 112 people
- Sponsor
- Assiut University
Obesity
Effects of Prebiotic-based Snacks on the Gut Microbiota and Perceived 'Satisfaction'
To determine the effects of prebiotic 'snacks' on gut health and satisfaction between meals
- Trial name
- NutriSAT (NCT02041975)
- Testing
- Nutriose FB06
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Reading
Liver Fibrosis, Liver Cirrhosis
Influence of Probiotics Administration Before Liver Resection in Liver Disease
Surgical resection is one of the curative treatment modalities for HCC. Limits are postoperative septic and liver functional complications related to an increase in bacterial translocation and systemic endotoxemia.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Permeability; Increased, Hepatocellular Carcinoma
- Trial name
- LIPROCES (NCT02021253)
- Testing
- Probiotic
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Rouen
Functional Dyspepsia, Gastroparesis
Brain-Gut Yoga for Functional Dyspepsia and Gastroparesis (FD-GP)
The purpose of this research study is to assess whether using a yoga-based intervention in practice is feasible (possible) and acceptable to patients with Functional Dyspepsia and/or Gastroparesis (FD-GP).
- Trial name
- FD-GP (NCT06732453)
- Testing
- Seated Yoga Skills Training in Functional Dyspepsia and Gastroparesis (FD-GP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Advanced Biliary Tract Cancer
NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer
This is a study to evaluate the clinical activity of the combination of fluorouracil, leucovorin, and nanoliposomal irinotecan as second-line treatment in patients with advanced biliary tract cancers following gemcitabine and…
- Trial name
- NCT04005339
- Testing
- Nanoliposomal Irinotecan, Leucovorin, Fluorouracil
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Georgetown University
Cholesterol, Elevated, Elevated Cholesterol
A Pilot Study to Explore the Role of Gut Flora in Elevated Cholesterol
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Elevated Cholesterol.
- Trial name
- NCT04148339
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Ultrasonography, Gastrointestinal Disease
Role of Intraoperative Ultrasound in Gastrointestinal (GI) Malignancies
Currently available investigating modalities like CT scans, MRI etc although have a high accuracy in staging of gastrointestinal(GI) tract malignancies, are not correct in all cases .
- Conditions
- Ultrasonography, Gastrointestinal Disease, Malignancy
- Trial name
- NCT01143922
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Obesity, Childhood, Antibiotic Side Effect
Microbiome, Antibiotics, and Growth Infant Cohort
This cross-disciplinary study will assemble and longitudinally follow a large, diverse birth cohort to determine the relationships between early life antibiotic exposure, microbiome development, growth, antibodies, and…
- Trial name
- MAGIC (NCT03001167)
- Where
- United States
- Volunteers
- 509 people
- Sponsor
- Children's Hospital of Philadelphia
Lower Gastrointestinal Bleeding, Diverticular Bleeding
Clinical Trial to Evaluate the Efficacy and Safety of Nexpowder™ for Diverticular Bleeding in the Lower Gastrointestinal Tract
Clinical Trial to Evaluate the Efficacy and Safety of Nexpowder™ for Diverticular Bleeding in the Lower Gastrointestinal Tract
- Trial name
- NCT06939907
- Testing
- Nexpowder™
- Where
- 6 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Next Biomedical Co., Ltd.
Sleep Disturbance, Mood Disturbance
Enhancement of Sleep Quality and Mood Following Supplementation With Lemon Balm in an Adult Population (Lemslp)
This study aims to investigate the effect of a 4-week dietary intervention of 300mg encapsulated aqueous lemon balm extract on measures of sleep quality, mood and well-being, alongside relevant biomarkers of circadian rhythms in…
- Trial name
- NCT05422599
- Testing
- Lemon balm
- Where
- United Kingdom
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Reading
Psoriasis Vulgaris With Metabolic Disorders
Metformin for Treatment of Psoriasis Combined With Disorders of Glucose and Lipid Metabolism
Psoriasis and metabolic disorders are well-known mutual comorbidities. The investigators hypothesized metformin can ameliorate both psoriasis and metabolic disorders mainly via gut microbiota modulation.
- Trial name
- MPGLM (NCT03629639)
- Testing
- Metformin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Central South University
Respiratory Aspiration of Gastric Contents
Gastric Ultrasound for Estimation of the Aspiration Risk Study
The purpose of this research study is to look at the effectiveness of current anesthesia guidelines regarding food and drink prior to surgery in patients who are likely to have food and drink remain in their stomach longer than…
- Trial name
- NCT03310528
- Testing
- Interview questionnaire, Gastric ultrasound exam
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Alzheimer Disease
Effect of Probiotics in Alzheimer's Disease
In this clinical trial, five strains of probiotics (Bifidobacterium breve Bv-889, B. longum subspecies infantis BLI-02, B. bifidum VDD088, B. animalis subsp.
- Trial name
- NCT05145881
- Testing
- Low dose probiotics, Normal dose probiotics
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Hsieh-Hsun Ho
CKD
Study of Oral Uremic Toxin Absorbent and Probiotics to Retard the Progression of Chronic Kidney Disease
In patients with chronic kidney disease (CKD), uremic toxins accumulate when kidney function declines. Those uremic toxins had a greater affinity to circulating proteins are called "protein bound uremic toxins, PBUT." Apart from…
- Trial name
- NCT04819217
- Testing
- Active bamboo charcoal, Probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Ulcerative Colitis (UC), Colorectal Cancer (CRC)
Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer
The goal of this observational pilot study with invasive measurements is to explore whether an ingestible sensor pill can be of use in diagnosis or monitoring of disease in patients with ulcerative colitis or colorectal cancer.
- Trial name
- SPIRIT (NCT07046468)
- Testing
- Ingestion of sensor capsule (twice), Device evaluation questionnaire, Wearing device
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Pancreatic Cancer
Gut Microbiome Modulation to Enable Efficacy of Checkpoint-based Immunotherapy in Pancreatic Adenocarcinoma
A multi-institutional, single arm pilot study of antibiotics and pembrolizumab for the treatment of surgically resectable pancreatic cancer.
- Trial name
- NCT03891979
- Testing
- Pembrolizumab, Ciprofloxacin 500mg PO BID days 1-29, Metronidazole 500mg PO TID days 1-29
- Where
- United States
- Sponsor
- NYU Langone Health
Obesity, Childhood
Pediatric Obesity Related Metabolite Profile and Gut Microbiota
In this study, the investigators aimed to observe changes in the gut microbial composition before and after the weight-loss intervention, including dietary control and exercise, in obese children.
- Trial name
- NCT03812497
- Testing
- Individualized Education Program
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Endstage Renal Disease
Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis
End-stage renal disease (ESRD) is associated with multiple comorbidities such as cardiovascular disease, anemia, mineral and bone disorders, malnutrition, body wasting, muscle loss (sarcopenia), neurological problems and…
- Trial name
- PLAN (NCT02976688)
- Testing
- Sodium Propionate
- Volunteers
- 15 people
- Sponsor
- Azienda Sanitaria ASL Avellino 2
Undernutrition
Microbiota and Protein-energy Wasting (MIDIWA)
Oral supplementation with branched chain amino acids (BCAA) increases the levels of circulating BCAA, stimulates BCAA uptake in muscles, and decreases amino acid release from muscle, eventually promoting muscle anabolism.
- Trial name
- MIDIWA (NCT02962089)
- Testing
- Branched chain amino acids (BCAA)
- Where
- 5 sites in Switzerland
- Volunteers
- 37 people
- Sponsor
- University Hospital, Geneva
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