Clinical trials: GI Tract Disorders
Ulcerative Colitis, Crohn Disease
A Multicentered Prospective Cohort Study of Chinese IBD Patients
Inflammatory bowel disease(IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic and recurrent nonspecific intestinal inflammation with high disability rate.
- Trial name
- NCT05386290
- Testing
- Infliximab, Vedolizumab, Ustekinumab
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Acute Myeloid Leukemia, Graft-versus-host-disease
Changes in the Gut Microbiota of Patients Undergoing Allogeneic Stem Cell Transplantation (COLLECT)
COLLECT is a monocentric, prospective, observational study, which aims to assess the association between changes in the intestinal microbiota and the incidence of gastrointestinal graft-versus-host diseases (GvHD).
- Conditions
- Acute Myeloid Leukemia, Graft-versus-host-disease, Allogeneic Hematopoietic Stem Cell Transplantation, Stem Cell Transplant Complications
- Trial name
- COLLECT (NCT03148197)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Cologne
Sarcopenia, Older Adults
Distinct Exercise Modalities on Gut Microbiome
Sarcopenia is a multifactorial muscular disease with detrimental clinical consequences, impairing physical function, functional independence, quality of life, need for long-term care and premature mortality.
- Trial name
- DEMGUTS (NCT06545123)
- Testing
- Concurrent exercise training
- Where
- Portugal
- Volunteers
- 69 people
- Sponsor
- Faculty of Sports- Research Center in Physical Activity, Health and Leisure
Irritable Bowel Syndrome, Healthy Subjects
Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction
Patients with disorders of gut-brain interaction (DGBI) often present gastrointestinal symptoms that do not show noticeable irregularities in standard examinations.
- Conditions
- Irritable Bowel Syndrome, Healthy Subjects, Functional Gastrointestinal Disorders, Laryngopharyngeal Reflux
- Trial name
- NCT06205446
- Testing
- Healthy subjects : abdominal breathing, Laryngopharyngeal reflux disease subjects : abdominal breathing, Dyspepsia subjects : abdominal breathing
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Acute Myeloid Leukemia With FLT3/ITD Mutation, Allogeneic Hematopoietic Stem Cell Transplantation
The Gut Microbiome and Sorafenib Maintenance Therapy in FLT3-ITD Positive AML After Allo-HSCT
This prospective trial investigates the effect of sorafenib maintenance therapy in FLT3-ITD positive AML patients after allo-HSCT in terms of gut microbiome.
- Trial name
- NCT05596968
- Testing
- Sorafenib
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Peritoneal Neoplasms
Pharmacokinetic, Safety and Efficacy Study of Nanoparticle Paclitaxel in Patients With Peritoneal Cancers
The purpose of this study is to evaluate the safety, pharmacokinetics and preliminary efficacy of an intraperitoneally administered suspension of nanoparticulate paclitaxel in patients with refractory malignancies principally…
- Trial name
- NCT00666991
- Testing
- nanoparticulate paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- CritiTech, Inc.
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Postoperative Delirium, Cardiac Disease
Multi-omics Analyses Reveal Microbiota-gut-brain Axis in ICU Patients With Post-cardiac Surgery Delirium
This case-control study is planned to recruit patients who meet the enrollment conditions, receive cardiac surgery (cardiac valve surgery or coronary artery bypass surgery) and cardiopulmonary bypass, and sign the informed…
- Conditions
- Postoperative Delirium, Cardiac Disease, Gastrointestinal Microbiome
- Trial name
- NCT05628480
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China National Center for Cardiovascular Diseases
Gut Microbiome, Inflammation
Targeted Metabolomics to Decipher Dietary Contributions to Pediatric Inflammatory Bowel Disease (IBD) - Main Study
The overall goal of the study is to investigate the dietary differences between children with well-controlled inflammatory bowel disease (IBD) and those with active disease by using targeted food metabolomics.
- Conditions
- Gut Microbiome, Inflammation, Irritable Bowel Syndrome
- Trial name
- TAMED IBD (NCT05014243)
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Irritable Bowel Syndrome
Effects of Low FODMAP Diet on Leaky Gut
The pathophysiology of Irritable bowel syndrome (IBS) is multifactorial involving complex interplay of altered intestinal permeability, mucosal immune activation, visceral hypersensitivity and gut dysbiosis.
- Trial name
- NCT04526808
- Testing
- FODMAP diet
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Deaconess Medical Center
Type 2 Diabetes
Effect of Bile Acid Sequestration on Postprandial GLP-1 Secretion, Glucose Homeostasis and Gut Microbiota
Accumulating evidence suggests that bile acids and bacteria in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis.
- Trial name
- NCT02061124
- Testing
- Sevelamer 1600 mg TID for 7 days
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
ADHD, Gastrointestinal
ADHD, Gut Problems and Synbiotic
The scope of this study is to evaluate the impact of a synbiotic product (a combination of probiotic bacteria and prebiotics) on symptoms reported by participants with ADHD.
- Conditions
- ADHD, Gastrointestinal, Emotion Regulation Abilities
- Trial name
- NCT07717359
- Testing
- Synbiotic Cap Gut-Brain
- Volunteers
- 174 people
- Sponsor
- Super Synbiotics AB
Melanoma, Stage II
Explorative Study on Addition of High-fiber Dried Chicory Root in Patients With an Intermediate to High-risk Cutaneous Melanoma.
Exploring the effect of supplementation with daily addition of prebiotic dried chicory root (WholeFiberTM) for 6 weeks on fecal SCFA levels, gut microbial composition and immune cell composition in minimal stage II A melanoma…
- Trial name
- MELFIB (NCT07206017)
- Testing
- prebiotic dried chicory root (WholeFiber)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Allergic Rhinitis
Effect of a Multistrain Probiotic on Allergic Rhinitis Symptoms and Gut Microbiota Composition in Atopic Patients
The purpose of the current study is to evaluate the efficacy of administering a multistrain probiotic in adult human subjects suffering from allergic rhinitis and evaluate both symptomatology through validated questionnaires and…
- Trial name
- NCT05344352
- Testing
- Multistrain Probiotic
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Università degli Studi di Ferrara
Patient Participation
Targeting the Gut Dysbiosis to Treat Inflammation-driven Synaptopathy in MS
Inflammatory synaptopathy is a prominent pathogenic process in multiple sclerosis (MS) induced by imbalanced immune system homeostasis. Its persistence causes excitotoxic neuronal damage, leading to motor and cognitive deficits.
- Trial name
- Pre-Pro-MS (NCT05779449)
- Testing
- Prebiotics and Probiotics supplementation, peripheral blood withdrawal, Transcranial Magnetic Stimulation (TMS)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Neuromed IRCCS
Multiple Sclerosis, Long Covid
Fatigue Investigation Using Digital Outcomes
This study investigates objective methods to measure and monitor fatigue in patients with post-COVID-19 condition (long COVID) and multiple sclerosis (MS), and includes a group of healthy volunteers for comparison.
- Conditions
- Multiple Sclerosis, Long Covid, Healthy
- Trial name
- FIDO (NCT07783074)
- Where
- 6 sites in Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Liliana Barrios
Ischemic Stroke
A Study of the Relationship of Gut Microbial Composition and Stroke Outcome
The purpose of this study is to investigate the relationship between gut microbiome (bacteria in the gut), inflammation and the injured brain.
- Trial name
- GEMSTONE (NCT03470506)
- Testing
- Stool Samples
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Virginia
Appetite, Energy Intake
Appetite Regulation and Mycoprotein
The purpose of this study is to investigate the effect of eating various levels of mycoprotein (Quorn) on feelings of appetite, energy intake and levels of gut hormones in overweight volunteers.
- Trial name
- mycoprotein (NCT02053025)
- Testing
- mycoprotein, control protein
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Digestive Health, Quality of Life
Effect of a Fermented Dairy Protein With Prebiotic Fiber on GI Complaints
A positive impact of a fermented dairy protein with prebiotic fiber supplement on self-reported GI complaints and wellbeing has been suggested (Wardenaar et al. 2024).
- Trial name
- NCT06946017
- Testing
- Fermented dairy protein with prebiotic fiber supplement
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Plasma Cell Disorders
Gut Microbiome Studies in Patients With POEMS Syndrome and Other Plasma Cell Disorders
A Study to Evaluate Gut Microbiome with POEMS Syndrome and Other Plasma Cell Disorders
- Trial name
- Microbiome (NCT06252948)
- Testing
- Non-interventional study (observational)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.