Clinical trials: GI-bleeding
Gastroduodenal Ulcer, Marginal Ulcer
Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT02724150
- Testing
- Omeprazole High dose, Omeprazole Low dose
- Where
- Syria
- Sponsor
- Damascus Hospital
Gastrointestinal Bleedings
Efficacy of Small Bowel Preparation in Capsule Endoscopy
The best preparation of small bowel is still unknown. The primary aim of this study is to evaluate the polyethylene glycol (PEG) impact of small bowel preparation for unexplained gastrointestinal bleeding exploration.
- Trial name
- PREPINTEST (NCT01267981)
- Testing
- Standard diet, Standard Diet + 500 ml of polyethyleneglycol, Standard diet + 2 liters of polyethylene glycol the day before + 500ml of polyethylene glycol
- Where
- 17 sites in France
- Volunteers
- 858 people
- Sponsor
- University Hospital, Brest
Occult GI Bleeding
A Prospective Evaluation of Same Day Bidirectional Endoscopy for Occult Bleeding
This study is a prospective evaluation of patients with occult (hidden) GI bleeding without iron deficiency. Such patients usually undergo a diagnostic colonoscopy as a standard of care.
- Trial name
- NCT00636597
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- US Department of Veterans Affairs
GI Bleeding
High Dose Oral Omeprazole in High Risk UGIB
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding.
- Trial name
- NCT04394663
- Testing
- High-dose oral omeprazole, Standard IV PPI
- Where
- 2 sites in Thailand
- Volunteers
- 128 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Atrial Fibrillation (AF), Major Gastrointestinal Bleeding (MGIB)
Resumption of Anticoagulation After Major Gastrointestinal Bleeding in Patients With Atrial Fibrillation
Prospective multicenter observational study on resumption of anticoagulant therapy after major gastrointestinal bleeding in patients with atrial fibrillation
- Trial name
- RAFTING-GIB (NCT07901699)
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- Società Italiana di Medicina Interna
Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage
Registry for Upper Gastrointestinal Bleeding
This project aims to evaluate the data on all patients undergoing endoscopic therapy for upper gastrointestinal bleeding.
- Trial name
- NCT04211194
- Testing
- Upper GI Endoscopy
- Where
- United States
- Volunteers
- 2,999 people
- Sponsor
- AdventHealth
Gastro Intestinal Bleeding, Ischaemic Heart Diseases
Gastrointestinal Bleeding is Blood Loss in the Digestive Tract, Classified as Upper or Lower. Ischemic Heart Disease is Due to Blocked Heart Arteries. Antiplatelet Drugs Help Prevent Heart Attacks But Increase GI Bleeding Risk, Especially When Used Together as Dual Therapy.
Gastrointestinal bleeding is blood loss in the digestive tract, classified as upper or lower. Ischemic heart disease is due to blocked heart arteries.
- Conditions
- Gastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
- Trial name
- NCT07125651
- Volunteers
- 112 people
- Sponsor
- Assiut University
Acute Upper Gastrointestinal Bleeding, Acute Variceal Bleeding
Timing of Endoscopy in Cirrhotic Patients With Acute Variceal Bleeding
Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in patients with liver cirrhosis.
- Trial name
- NCT06031402
- Testing
- Endoscopy
- Where
- China
- Volunteers
- 368 people
- Sponsor
- General Hospital of Shenyang Military Region
Peptic Ulcer Bleeding
Tegoprazan Versus Lansoprazole for Endoscopic Ulcer Healing in Bleeding Peptic Ulcers
This clinical trial compares two medicines used to treat bleeding stomach ulcers in people in Indonesia. The researchers want to find out whether tegoprazan or lansoprazole is better at healing these ulcers after 2 weeks of…
- Trial name
- NCT07708545
- Testing
- Tegoprazan tablet, Lansoprazole capsules
- Where
- 3 sites in Indonesia
- Volunteers
- 162 people
- Sponsor
- Universitas Indonesia
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
GI Bleeding, Perforation Colon
Evaluation of the Clinical Utility of Endoscopic Closure Using a Dual Action Tissue (DAT) Clip
This study is designed as a multicenter prospective data recording study to document the performance of the DAT clip as part of standard medical care of patients. No experimental interventions will be performed.
- Conditions
- GI Bleeding, Perforation Colon, Perforation Bowel, Perforation Duodenal
- Trial name
- NCT05852457
- Testing
- DAT Clip
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- AdventHealth
Hemorrhage, Hemorrhagic Shock
Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock
This single-center, prospective, randomized controlled trial was approved by the institutional ethics committee and overseen by an independent data and safety monitoring board.
- Conditions
- Hemorrhage, Hemorrhagic Shock, Upper Gastrointestinal Bleeding (UGIB)
- Trial name
- NCT07129031
- Testing
- low-titer O-group whole blood, 1:1:1 component transfusion, ABO- and Rh-compatible whole blood
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital
Acute Upper Gastrointestinal Bleeding
Factors Predicting the Need for Endoscopic Intervention in Non-variceal Upper Gastrointestinal Bleeding
Gastrointestinal system bleedings are medical emergencies and the most common cause of hospital admissions related to digestive system diseases.
- Trial name
- NCT05979025
- Where
- Turkey (Türkiye)
- Volunteers
- 262 people
- Sponsor
- Ankara City Hospital Bilkent
Gastro Intestinal Bleeding, Polyps
Nexpowder to Prevent Delayed Bleeding After Endoscopic Resection
Safety and effectiveness of a new hemostatic system to prevent delayed bleeding after endoscopic resection in a selected high-risk population (NEXPOWDER- ENDOHS).
- Trial name
- NEX-ENDOHS (NCT06096948)
- Testing
- NEXPOWDER-ENDOHS
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasme University Hospital
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Cystic Fibrosis Liver Disease, Portal Hypertension Due to Cystic Fibrosis (Disorder)
Pre-emptive Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Cystic Fibrosis Related Liver Disease
Portal hypertension (PHT) and its sequelae are the most clinically important manifestation in cystic fibrosis related liver disease (CFLD), with end-stage liver failure as a late and rare manifestation.
- Conditions
- Cystic Fibrosis Liver Disease, Portal Hypertension Due to Cystic Fibrosis (Disorder), Portal Hypertension, Noncirrhotic
- Trial name
- NCT05037643
- Testing
- TIPS
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent
Peptic Ulcer Hemorrhage
Supplementary Angiographic Embolization for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common disorder. Despite optimal endoscopic and medical treatment, there is a high risk of rebleeding and high mortality.
- Trial name
- NCT01125852
- Testing
- Angiographic embolization, Therapeutic endoscopy
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- Odense University Hospital
Gastro Intestinal Bleeding, Hematemesis
Study of Early Endocapsule (EC) in Clinical Decision Unit Versus Standard of Care Work-up for GI Bleeding
This study will evaluate the use of the Olympus EndoCapsule EC-10 video capsule compared with the standard of care workup for patients in the Clinical Decision Unit who have symptoms of gastrointestinal (GI) bleeding.
- Conditions
- Gastro Intestinal Bleeding, Hematemesis, Melena
- Trial name
- NCT03955055
- Testing
- Video Capsule Endoscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Christopher Marshall
GastroIntestinal Bleeding, Anemia
Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation.
- Trial name
- FIERCE (NCT05060731)
- Testing
- Oral iron supplementation, Intravenous iron supplementation
- Where
- Hungary
- Volunteers
- 570 people
- Sponsor
- University of Pecs
Endoscopic Surgical Procedures
Endoscopic Hand Suturing in the Prevention of Gastrointestinal Bleeding After Gastric Endoscopic Submucosal Dissection.
Endoscopic hand-suturing (EHS) is a significant improvement in gastrointestinal advanced endoscopic procedures. Evidence supporting its effectiveness in clinical practice is limited due to its recent introduction and limited…
- Trial name
- NCT06779266
- Testing
- Suturing, Clipping, No closure
- Where
- Poland
- Volunteers
- 179 people
- Sponsor
- Jagiellonian University