Clinical trials: GI-bleeding
Peptic Ulcer Hemorrhage
Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients
The purpose of this study is to determine whether a long-term prophylactic use of esomeprazole 20 mg twice daily or once daily has prevention effectiveness in reducing the recurrence of peptic ulcer bleeding after ulcer healed…
- Trial name
- Eso_1y_R6PUB (NCT02456012)
- Testing
- oral esomeprazole 20 mg twice daily, oral esomeprazole 20 mg once daily
- Where
- Taiwan
- Volunteers
- 268 people
- Sponsor
- Hsiu-Chi Cheng
Gastrointestinal Hemorrhage, Postoperative Hemorrhage
The Major Bleeding Risk Following Hepatectomy
This study examined long-term incidence rates of major bleeding associated with hepatectomy. The investigators used data from Taiwan's National Health Insurance Research Database.
- Conditions
- Gastrointestinal Hemorrhage, Postoperative Hemorrhage, Surgery--Complications
- Trial name
- NCT04748081
- Testing
- hepatectomy
- Where
- Taiwan
- Volunteers
- 5,265 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Lower GI Bleeding
Acute Lower gastroIntestinal BleedIng (ALIBI Study) in Italy
Unlike upper GI bleeding, for LGIB there is still a paucity of data on clinical presentation, patient characteristics, pathways of care and outcomes for LGIB patients.
- Trial name
- ALIBI (NCT04364412)
- Where
- Italy
- Volunteers
- 1,198 people
- Sponsor
- Valduce Hospital
Rectal Bleeding
Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis
Randomized trial of Argon Plasma Coagulation compared with Argon Plasma Coagulation and Hemospray in the therapy of bleeding from Radiation Proctitis
- Trial name
- NCT02233933
- Testing
- Hemospray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Myocardial Infarction, Helicobacter Pylori Infection
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction
Background: Potent antithrombotic therapy has improved prognosis for patients with acute myocardial infarction (MI) significantly, however, at a price of increased bleeding risk. Helicobacter pylori (H.
- Conditions
- Myocardial Infarction, Helicobacter Pylori Infection, GastroIntestinal Bleeding, Cardiovascular Diseases
- Trial name
- HELP-MI (NCT05024864)
- Testing
- Urea breath test (UBT)
- Where
- 35 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Peptic Ulcer
Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding
To assess the efficacy and safety of the early administration of somatostatin in infusion during 72 hours plus 2 boluses, compared to placebo in the control of acute severe UGIB with suspicion of PUB.
- Trial name
- NCT00152399
- Testing
- Somatostatin UCB (drug)
- Where
- 22 sites in Belgium, France and 4 more
- Volunteers
- 370 people
- Sponsor
- UCB Pharma
Small Bowel Bleeding
Early Videocapsule Endoscopy for Upper Gastrointestinal Bleeding
The objective of this study is to determine whether early video capsule endoscopy (VCE) immediately after a negative gastroscopy in the setting of suspected upper gastrointestinal bleeding (UGIB) improves patient outcomes as…
- Trial name
- NCT05108844
- Testing
- Videocapsule endoscopy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Gastrointestinal Bleeding, Cirrhosis
Effects of the Administration of Ornithine Phenylacetate in Patients With Cirrhosis and Upper Gastrointestinal Bleeding
The main objective is to evaluate the effectiveness of the experimental drug to reduce plasma ammonia concentration at a dose that is safe and well tolerated.
- Trial name
- NCT01434108
- Testing
- Ornithine-phenylacetate
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Gastrointestinal Bleeding
Safety Study of Octreotide Injection to Prevent GI Bleeding in Patients With Left Ventricular Assist Device (LVAD)
The investigators hypothesize that octreotide LAR (Long Acting Release) safely decreases GI bleeding in patients with a left ventricular assist device (LVAD).
- Trial name
- NCT01707225
- Testing
- Octreotide LAR Depot
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Gastrointestinal Hemorrhage
Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial
This study tests the feasibility of a large study of stress ulcer prophylaxis in critically ill children. Children admitted to the Pediatric Intensive Care Unit who are expected to require mechanical ventilation for more than 48…
- Trial name
- PIC-UP (NCT02929563)
- Testing
- Pantoprazole
- Where
- 7 sites in Canada
- Volunteers
- 116 people
- Sponsor
- McMaster University
Bleeding
Potassium-competitive Acid Blocker Versus Double Dose Proton Pump Inhibitors in High High-risk Peptic Ulcer Bleeding
This randomized clinical trial will enroll patients at National Cheng Kung University Hospital who have upper gastrointestinal ulcer bleeding, have undergone endoscopic hemostasis, and have a Rockall score of 6 or higher.
- Trial name
- NCT07772700
- Testing
- Vonoprazon, Esomeprazole
- Volunteers
- 108 people
- Sponsor
- National Cheng-Kung University Hospital
Angiodysplasia
Pasireotide for the Treatment of Gastrointestinal Angiodysplasia in Endoscopic Treatment Failure
The angiodysplasias may be responsible for recurrent gastrointestinal bleeding and in some cases bleeding remaining inaccessible to endoscopic treatment.
- Trial name
- ANGIOPAS (NCT02622906)
- Testing
- Pasireotide
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Robert Benamouzig
Hemorrhage, Anemia
Capsule Endoscopy Versus Conservative Therapy for Obscure Gastrointestinal Bleeding
This study is a single center prospective randomized control trial comparing the utility of performing capsule endoscopy compared to conservative management with oral iron therapy as the initial course of action in patients with…
- Trial name
- NCT01837030
- Testing
- Ferrous sulfate, Capsule Endoscopy
- Where
- United States
- Sponsor
- Medical University of South Carolina
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Anticoagulants, Drug Interactions
Shared Decision for Drug Interactions in Oral Anticoagulation
The purpose of this project is to implement and evaluate a shared-decision making (SDM) tool called DDInteract that was developed to support decision making for drug-drugs interactions while on oral anticoagulants.
- Trial name
- DDInteract (NCT06401863)
- Testing
- Shared Decision Making Tool
- Where
- 3 sites in United States
- Volunteers
- 610 people
- Sponsor
- University of Utah
Gastrointestinal Hemorrhage
Evaluation the Performance of Given Diagnostic System in Detection of Bleeding Events in the Small Bowel
Obscure gastrointestinal bleeding (OGIB) has been one of the most challenging area in the field of gastroenterology, as small bowel is beyond the reach of ordinary endoscopes like oesophagogastroduodenoscopy (OGD) and…
- Trial name
- NCT01441219
- Testing
- Colon 2
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Chinese University of Hong Kong
Necrotizing Enterolitis
NIRS and Doppler to Predict NEC in Risk Neonates
The main objective is to evaluate the interest of cerebro-splanchnic oxygenation ratio (CSOR) for early diagnosis of necrotizing enterocolitis (NEC) in neonates with rectal bleeding and/or abdominal distension.
- Trial name
- NeoNIRS (NCT01833000)
- Testing
- Cerebral and splanchnic ear infrared spectroscopy (NIRS) and mesenteric Doppler
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Montpellier
Peptic Ulcer Bleeding
Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
The investigators used two different doses of esomeprazole (40 mg IV q.d. and 40 mg IV q6h for three days followed by esomeprazole 40 mg q.d.
- Trial name
- lowdosePPI (NCT04407832)
- Testing
- heat probe or hemoclip
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital
Gastrointestinal Hemorrhage, Anemia
Efficacy of Parenteral Iron Supplementation After Gastrointestinal Bleeding in Subjects Over 65
The upper and lower gastrointestinal bleeding, not related to portal hypertension, is a common disorder in the elderly. Indeed, in 1996, in a French study, the median age of patients hospitalized for upper gastrointestinal…
- Trial name
- FerHem (NCT01690585)
- Testing
- Ferinject 1000 mg, Sodium chlorure 0,9 %
- Where
- 13 sites in France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Rouen
Pilot Study, Clips
Clinical Trial of Metal-Reinforced Teeth Designed for Endoscopic Clips
Postoperative gastrointestinal complications following ESD, EMR, and EFTR procedures, such as gastrointestinal bleeding, diverticula, fistulas, perforations, and stent fixation, can be effectively treated through gradual…
- Trial name
- NCT06285955
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing 302 Hospital