Clinical trials: GI-bleeding
Upper Gastrointestinal Bleeding
Oral vs Intravenous and Proton Pump Inhibitor (PPI）for Peptic Ulcer Bleeding (PUB)
A bleeding peptic ulcer remains a serious medical problem with significant morbidity and mortality. Endoscopic therapy significantly reduces further bleeding, surgery, and mortality in patients with bleeding peptic ulcers and is…
- Trial name
- NCT01123031
- Testing
- lansoprazole, esomeprazole
- Sponsor
- Changhua Christian Hospital
Portal Hypertension, Cirrhosis
The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed
Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies.
- Conditions
- Portal Hypertension, Cirrhosis, Hematemesis, Melena
- Trial name
- NCT00534677
- Testing
- Terlipressin, Octreotide
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- Aga Khan University
Congenital Heart Disease, Upper Gastrointestinal Bleeding
Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease
Infants with congenital heart disease often require an intervention during their first year of life. Infants are generally admitted to a cardiac intensive care unit and are routinely prescribed stress ulcer prophylaxis to…
- Conditions
- Congenital Heart Disease, Upper Gastrointestinal Bleeding, Stress Ulcer, Infection
- Trial name
- SUPPRESS-CHD (NCT03667703)
- Testing
- Famotidine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Children's Hospital
Gastrointestinal Bleeding
Tranexamic Acid for The Treatment of Gastrointestinal Bleeding
Studies showed that in cases of gastrointestinal bleeding, injection tranexamic acid decreasing the risk of death and the need of surgical intervention.
- Trial name
- NCT03540368
- Testing
- Tranexamic acid injection
- Where
- Indonesia
- Volunteers
- 48 people
- Sponsor
- Universitas Indonesia
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Obscure Gastrointestinal Bleeding, Angiodysplasia
Long-term Effects of Thalidomide for Recurrent Gastrointestinal Bleeding Due to Vascular Malformation
Background: Repeated episodes of bleeding from gastrointestinal vascular malformations refractory to endoscopic or surgical therapy often pose a major therapeutic challenge.
- Conditions
- Obscure Gastrointestinal Bleeding, Angiodysplasia, Gastric Antral Vascular Ectasia, Thalidomide
- Trial name
- NCT00964496
- Testing
- Thalidomide, Iron
- Volunteers
- 55 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Colonic Diverticula, Angiodysplasia
Study of Hemospray for Lower Gastrointestinal Hemorrhage
This study is to evaluate the performance of Hemospray for the teatment of nonvariceal lower gastrointestinal bleeding.
- Conditions
- Colonic Diverticula, Angiodysplasia, Colonic Polyp
- Trial name
- NCT02099435
- Testing
- Hemospray
- Where
- 4 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Cook Group Incorporated
Liver Cirrhosis
Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis
The management of acute upper gastrointestinal bleeding (UGIB) is challenging in patients with cirrhosis, as it is responsible for severe complications and high mortality rates.
- Trial name
- NCT04489108
- Testing
- Tranexamic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Lower Gastrointestinal Bleeding
MSCT Angiography in Bleeding
Lower gastrointestinal bleeding occurs distal to the ligament of treitz and may involve the small bowel, colon and rectum . Active lower gastrointestinal bleeding is a common, potentially life threatening medical presentation…
- Trial name
- NCT03464513
- Testing
- Multislice CT Angiography
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Non-variceal Upper GI-bleeding With High Risk of Recurrency - OTSC (Over-the-scope-clip) Versus Standard Therapy (STING2)
Prospective-randomized multi-center trial. Patients with high risk of recurrent GI-bleeding (non-variceal) are identified and randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard…
- Trial name
- STING2 (NCT03331224)
- Testing
- OTSC, Endoscopic Standard therapy (combining two methods)
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Upper Gastrointestinal Bleeding
Efficacy Test of Real-Time Upper Gastrointestinal Monitoring System
A monitoring system was developed for detecting upper gastrointestinal (UGI) rebleeding. This system consists of (1) a tiny endoscopy, (2) a wearable device, and (3) a software.
- Trial name
- NCT03680950
- Testing
- Upper Gastrointestinal Monitoring System
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Cheng-Kung University Hospital
Gastro Intestinal Bleeding
Clinical-biological Score for Upper Gastrointestinal Bleeding
Gastrointestinal bleeding is a frequent reason for consultation in the Emergency Department. It is a real emergency associated with fairly significant morbidity and mortality.
- Trial name
- NCT05688501
- Testing
- descriptiv group
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Hôpital Universitaire Sahloul
Peptic Ulcer Bleeding
The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers
Patients with comorbidities have an increased risk of ulcer re-bleeding, especially within the 14 days after first bleeding event.
- Trial name
- DDE (NCT01591083)
- Testing
- esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
- Where
- Taiwan
- Volunteers
- 474 people
- Sponsor
- National Cheng-Kung University Hospital
Gastro Intestinal Bleeding
The Value of End-tidal Capnography in Gastrointestinal Bleeding
Gastrointestinal bleeding is a condition that frequently presents to emergency departments and can be fatal if diagnosis and treatment are delayed.
- Trial name
- NCT06345456
- Testing
- End-tidal capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Izmir Katip Celebi University
Arteriovenous Malformation, Gastrointestinal Bleed
Case-Specific Health Care Professional Clinical Survey for Concerto Versa™ Detachable Coils
The purpose of the Case-Specific Health Care Professional (HCP) Clinical Survey for Concerto Versa™ Detachable Coils, also known as the Concerto Versa HCP Clinical Assessment, is to collect early clinical data from HCPs to assess…
- Conditions
- Arteriovenous Malformation, Gastrointestinal Bleed, Gastric Varices, Hemorrhoid
- Trial name
- NCT07639853
- Testing
- Concerto Versa™ Detachable Coils
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medtronic Endovascular
Gastrointestinal Hemorrhage, Diabetes Complications
Therapeutic Conflicts and Multimorbidity
Clinical practice guidelines do not take into account multimorbidity and various potential therapeutic conflicts. Identifying and quantifying therapeutic conflicts is crucial in multimorbid patients having more than two acute or…
- Conditions
- Gastrointestinal Hemorrhage, Diabetes Complications, Multimorbidity
- Trial name
- NCT02928939
- Testing
- drug-drug or drug-disease interaction
- Where
- Switzerland
- Volunteers
- 1,101 people
- Sponsor
- University of Zurich
Hemorrhage, Trauma
RE-BLEED: A Digital Platform for Identifying Bleeding Patients - a Feasibility Study
The RE-BLEED feasibility study aims to develop and test a real-time digital platform, whereby bleeding patients in-hospital can be identified and approached for their consent to participate in future research studies.
- Conditions
- Hemorrhage, Trauma, Gastro Intestinal Bleeding
- Trial name
- RE-BLEED (NCT05608577)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Esophageal and Gastric Varices
Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
The purpose of this study is to develop a grading system for esophageal varices using capsule endoscopy in patients with portal hypertension and cirrhosis.
- Trial name
- NCT00475592
- Testing
- Esophageal Capsule Endoscopy, Upper Gastrointestinal Endoscopy
- Where
- United States
- Sponsor
- Johns Hopkins University
Haematochezia
Clinical Characteristics, Etiologies, and Outcomes of Patients With Haematochezia at Al-Rajhi University Hospital.
Haematochezia is the passage of bright red or maroon blood or blood clots from the rectum, usually originates from a source in lower parts of the gastrointestinal (GI) tract In addition, haematochezia can be seen in patients with…
- Trial name
- NCT07157228
- Volunteers
- 70 people
- Sponsor
- Assiut University
Peptic Ulcer Bleeding, Hypoalbuminemia
The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia
To test whether intravenous albumin can decrease the rebleeding rate or shorten the duration of hospitalization in patients with peptic ulcer bleeding and hypoalbuminemia.
- Trial name
- NCT01822600
- Testing
- Human albumin, Omeprazole
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Cheng-Kung University Hospital