Clinical trials: GI-bleeding
Bleeding Peptic Ulcers
Hemostasis of Active Gastrointestinal (GI) Luminal Tract Bleeding
The objective of this study is to show that Hemospray is effective in achieving initial hemostasis and documenting rate of further bleed when compared to standard of care.
- Trial name
- HALT (NCT01306864)
- Testing
- Hemospray Kit
- Where
- 12 sites in Canada, Hong Kong and 2 more
- Volunteers
- 67 people
- Sponsor
- Cook Group Incorporated
Venous Thromboembolism, Deep Venous Thrombosis
A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE
This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and bleeding in patients with gastrointestinal…
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism
- Trial name
- MAGNOLIA (NCT05171075)
- Testing
- Abelacimab, Dalteparin
- Where
- 117 sites in United States, Australia and 18 more
- Volunteers
- 417 people
- Sponsor
- Anthos Therapeutics, Inc.
Hemorrhage, Anemia
Capsule Endoscopy Versus Conservative Therapy for Obscure Gastrointestinal Bleeding
This study is a single center prospective randomized control trial comparing the utility of performing capsule endoscopy compared to conservative management with oral iron therapy as the initial course of action in patients with…
- Trial name
- NCT01837030
- Testing
- Ferrous sulfate, Capsule Endoscopy
- Where
- United States
- Sponsor
- Medical University of South Carolina
Obscure Gastrointestinal Bleeding, Iron-Deficiency Anemia
Endoscopic Evaluation for Iron Deficiency Anemia in Patients on Antithrombotic Therapy
This is a single-center, randomized pilot study evaluating the feasibility and safety of two management strategies for patients on antithrombotic therapy who present with obscure gastrointestinal bleeding (OGIB).
- Conditions
- Obscure Gastrointestinal Bleeding, Iron-Deficiency Anemia, Antithrombotic Therapy
- Trial name
- BEACON-IDA (NCT07089030)
- Testing
- Standard endoscopic evaluation, Conservative Medical Management
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
Upper Gastrointestinal Bleeding
PuraStat® Combined With Adrenaline Versus Standard of Care in Upper Gastrointestinal Bleeding
PuraStat® is a novel gel that offers several advantages over traditional hemostatic powders. Its transparency allows for continuous visualization of the bleeding site, and it can be applied in narrow spaces or in combination with…
- Trial name
- NCT06896409
- Testing
- PuraStat® combined with Adrenaline, Standard of Care
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Tallaght University Hospital
Upper Gastrointestinal Bleeding (UGIB), Glasgow-Blatchford Score
External Validation of the Glasgow-Blatchford Bleeding Score in a Tunisian Population
This study aims to externally validate the Glasgow-Blatchford Score (GBS) in a Tunisian population presenting with non-traumatic upper gastrointestinal bleeding.
- Trial name
- NCT07089277
- Where
- Tunisia
- Volunteers
- 250 people
- Sponsor
- Hôpital Universitaire Sahloul
Upper Gastrointestinal Bleeding
Efficacy Test of Real-Time Upper Gastrointestinal Monitoring System
A monitoring system was developed for detecting upper gastrointestinal (UGI) rebleeding. This system consists of (1) a tiny endoscopy, (2) a wearable device, and (3) a software.
- Trial name
- NCT03680950
- Testing
- Upper Gastrointestinal Monitoring System
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- National Cheng-Kung University Hospital
Venous Thromboembolism, Gastro Intestinal Bleeding
Reducing Gastrointestinal Bleeding With Proton Pump Inhibitor Therapy in Acute Venous Thromboembolism
The investigators are studying whether treatment with a proton pump inhibitor called omeprazole reduces gastrointestinal bleeding in older adults taking blood thinners for a blood clot (venous thromboembolism).
- Conditions
- Venous Thromboembolism, Gastro Intestinal Bleeding, Blood Clot
- Trial name
- NCT06393868
- Testing
- Omeprazole 20 mg Oral Tablet
- Where
- 7 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Ottawa Hospital Research Institute
Gastrointestinal Bleeding
The Effectiveness of Video-capsule Endoscopy in Gastrointestinal Bleeding of Obscure Origin
The study objective is to compare the cost-effectiveness of VCE to push enteroscopy in patients with gastrointestinal bleeding of obscure origin with a negative initial work-up.
- Trial name
- NCT01424254
- Testing
- Capsule GIVEN IMAGING, Push-Enteroscopy
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Occult Gastrointestinal Bleeding, Upper Gastrointestinal Bleeding (UGIB)
PillSense Use in Anemia and Hemoccult
In this study, participants will be offered a PillSense™ capsule, a small capsule to swallow, which can detect the presence of blood in the upper digestive tract within about 10 minutes.
- Trial name
- PillSense™ (NCT06951490)
- Testing
- PillSense™
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- AdventHealth
Gastrointestinal Hemorrhage, Hematemesis; With Ulcer
Efficacy and Safety of Nexpowder™ for Non-variceal, Upper Gastrointestinal Bleeding
The purpose of this pilot clinical trial is to confirm the efficacy and safety of Nexpowder™ for hemostasis in pilot cohort of patients with NVUGIB in Singapore
- Conditions
- Gastrointestinal Hemorrhage, Hematemesis; With Ulcer, Endoscopy
- Trial name
- NCT06269588
- Testing
- Nexpowder
- Where
- Singapore
- Volunteers
- 24 people
- Sponsor
- Changi General Hospital
Upper Gastrointestinal Bleeding
HALP as a Novel Score for Prediction of Mortality and re_bleeding in Upper GIT Bleeding
Evaluation of the prognostic utility of the HALP score in patients with upper gastrointestinal bleeding, particularly in predicting re_bleeding risk and mortality in internal medicine department in Sohag University Hospitals.
- Trial name
- NCT07114042
- Testing
- Upper endoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Diarrhea Bloody
Improvements Through the Use of a Rapid Multiplex PCR Enteric Pathogen Detection Kit in Children With Hematochezia
Children presenting for emergency department (ED) care with bloody diarrhea (i.e. hematochezia) represent a diagnostic challenge.
- Trial name
- NCT03362970
- Testing
- BioFire Gastrointestinal Panel FilmArray®, Standard of Care
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Calgary
Lower GI Bleeding
Acute Lower gastroIntestinal BleedIng (ALIBI Study) in Italy
Unlike upper GI bleeding, for LGIB there is still a paucity of data on clinical presentation, patient characteristics, pathways of care and outcomes for LGIB patients.
- Trial name
- ALIBI (NCT04364412)
- Where
- Italy
- Volunteers
- 1,198 people
- Sponsor
- Valduce Hospital
Upper Gastrointestinal Bleeding (UGIB), Emergency Department Patient
A New Risk Score for the Emergency Department in Patients With Upper Gastrointestinal Bleeding
Abstract Background: The aim of this study was to develop a simpler, more practical, and highly effective risk scoring system for patients presenting to the emergency department with upper gastrointestinal bleeding.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Emergency Department Patient, Risk Scores
- Trial name
- NCT06878183
- Testing
- Routine laboratory tests of the patients were examined (such as hemogram, biochemistry, bleeding parameters).
- Where
- Turkey (Türkiye)
- Volunteers
- 589 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Nonvariceal Upper Gastrointestinal Bleeding
Comparison of Oral Rabeprazole vs. iv Omeprazole in Mild to Moderate Nonvariceal Upper Gastrointestinal Bleeding
Introduction: Proton pump inhibitor (PPI) is the drug of choice used in patients with non-variceal upper gastrointestinal tract bleeding (UGIB).
- Trial name
- NCT00861640
- Testing
- Intravenous Omeprazole, Oral Rabeprazole
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Gastroduodenal Ulcer, Marginal Ulcer
Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT02724150
- Testing
- Omeprazole High dose, Omeprazole Low dose
- Where
- Syria
- Sponsor
- Damascus Hospital
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Colon Cancer, Inflammatory Bowel Diseases
Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
The study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Gastrointestinal Bleed, Colon Polyp
- Trial name
- NCT05726097
- Testing
- polyethylene glycol, sodium phosphate, polyethylene glycol + ascorbic acid
- Where
- Sweden
- Volunteers
- 147 people
- Sponsor
- Region Skane
Lower Gastrointestinal Bleeding
Oakland-Jairath Score Validation
Lower gastrointestinal bleeding (LGIB) is a common presentation in the Emergency Room. It can deteriorate into severe adverse event. However some are discharged before these events occur.
- Trial name
- NCT03935360
- Testing
- Oakland-Jairath Risk Score
- Where
- 6 sites in Canada
- Volunteers
- 344 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's