Clinical trials: Gait Disorder
Amputation, Diabetes
Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit
The fit of the residual limb within a prosthetic socket is a primary concern for many amputees. A poor fit can lead to skin irritation, tissue breakdown, and pain.
- Conditions
- Amputation, Diabetes, Leg Injuries, Traumatic Amputations
- Trial name
- NCT00117793
- Testing
- Total Surface Bearing Suction Socket, Vacuum assisted socket system
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Stroke
Effects of an Overground Propulsion Neuroprosthesis in Community-dwelling Individuals After Stroke
This interventional study evaluates the effects of an overground propulsion neuroprosthesis that delivers adaptive neurostimulation assistance to the paretic plantarflexors and dorsiflexors of people post-stroke.
- Trial name
- NCT06459401
- Testing
- Propulsion Neuroprosthesis
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Boston University Charles River Campus
Cerebral Palsy
Investigating the Effect of Stochastic Resonance Vibration on Gait and Balance and Upper Extremity Function in Children With Cerebral Palsy
The purpose of this research study is to determine the effects of wearable vibration devices for children with cerebral palsy and impaired arm function.
- Trial name
- NCT04388787
- Testing
- Stochastic resonance (SR) wraps
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Virginia Commonwealth University
Stroke
Sensory Augmentation Methods in Stroke
Many chronic stroke survivors have poor walking balance, contributing to an increased risk of falls and fear of falling. One factor contributing to these balance deficits is a reduced ability to place the feet appropriately when…
- Trial name
- SAM (NCT03988400)
- Testing
- Sensory Augmentation, Random Vibration
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes Mellitus
Memory Aid by Intranasal Insulin in Diabetes (MemAID)
The main purpose of this study is to find the long-term effects of daily administration of 40 IU of intranasal insulin (INI) as compared to placebo (sterile saline) on cognition and memory in people with type 2 diabetes mellitus…
- Trial name
- MemAID (NCT02415556)
- Testing
- Regular Human Insulin
- Where
- 2 sites in United States
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cerebral Palsy, Children
Does Increasing Auditory Cueing Affect Gait Parameters in Children With Cerebral Palsy During a Functional Task?
To determine the clinical efficacy of auditory cueing using a cross over design to investigate whether increasing auditory cueing frequency by 20% above self paced cadence affects gait parameters in children with Cerebral Palsy…
- Trial name
- NCT02666560
- Testing
- Auditory Cueing
- Volunteers
- 19 people
- Sponsor
- Institute of Child Health
Depressive Disorder
Levodopa and Exercise for Older Adults With Depression and Psychomotor Slowing
In this new research study, 80 adults aged > 60 years with a significant depressive disorder and slowed processing and/or gait speed will be randomized to receive levodopa (L-DOPA; which the Candidate has previously shown to…
- Trial name
- NCT04650217
- Testing
- Carbidopa/levodopa, Exercise training, Control
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
Stroke
Adaptive Hip Exoskeleton for Stroke Gait Enhancement
This work will focus on new algorithms for robotic exoskeletons and testing these in human subject tests. Individuals who have previously had a stroke will walk while wearing a robotic exoskeleton on a specialized treadmill as…
- Trial name
- NCT05536739
- Testing
- Hip exoskeleton, Baseline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Georgia Institute of Technology
Stroke
A Novel Mechanics-based Intervention to Improve Post-stroke Stability
The purpose of this study is to determine whether a novel treadmill training intervention can improve the gait stabilization strategy used by individuals who have experienced a stroke.
- Trial name
- NCT02964039
- Testing
- Error reduction, Error augmentation, Activity matched control
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Orthostatic Hypotension, Idiopathic Parkinson Disease
Lundbeck TOMs Orthostatic Hypotension
Orthostatic hypotension (OH), which consists in a significant reduction in blood pressure levels upon standing from a seated position, may affect approximately one in three patients with Parkinson's disease (PD).
- Trial name
- NCT04510922
- Testing
- Droxidopa 100 MG [Northera]
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Alberto Espay, MD, MSc
Parkinson's Disease
Genetic Influences on Response to Gait Rehabilitation in Parkinson's Disease
The aging Veteran population, together with high exposure to Agent Orange or other herbicides during military service, has made diseases such as Parkinson's disease (PD), currently affecting more than 80,000 Veterans, a major…
- Trial name
- Gen-Ex (NCT03607695)
- Testing
- Gait training
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
Lipoic Acid for Progressive Multiple Sclerosis (MS)
The purpose of the study is to determine if lipoic acid can preserve mobility and protect the brain in progressive forms of multiple sclerosis.
- Trial name
- LAPMS (NCT03161028)
- Testing
- Lipoic acid
- Where
- 11 sites in United States, Canada
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee
Effect of Knee Pain on Walking Biomechanics
The goal of this study is to determine if pain in one knee influences loading of the other knee during different types of walking.
- Trial name
- NCT05670236
- Testing
- Lidocaine Hydrochloride
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Stroke
Development of Walk Assist Device to Improve Community Ambulation
Hypothesis/Specific Aims: The purpose of this study is to determine the effect of training with the Stride Management Assist (SMA) device vs.
- Trial name
- NCT01994395
- Testing
- The Stride Management Assist (SMA) System, Impairment based therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Biofeedback to Increase Propulsion During Walking After Stroke
Approximately 15,000 Veterans are hospitalized for stroke each year with new cases costing an estimated $111 million for acute inpatient, $75 million for post-acute inpatient, and $88 million for follow-up care over 6 months…
- Trial name
- NCT02667392
- Testing
- Gait Training with Biofeedback, Gait Training with Verbal Feedback
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
The purpose of the study is to learn about the effect of GOCOVRI (Amantadine extended release) on activity levels and measures of gait and balance quality in people with Parkinson's disease (PD) and levodopa induced dyskinesia…
- Trial name
- NCT04387773
- Testing
- GOCOVRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome
Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Postacute Sequelae of Sars-CoV-2
The purpose of the pilot study is to examine acceptability and proof of concept effectiveness of a wireless TENS technology to address PASC associated FM.
- Conditions
- Postacute Sequelae of Sars-CoV-2, Post-Acute COVID-19 Syndrome, Widespread Chronic Pain, Fatigue Syndrome, Chronic
- Trial name
- NCT05200858
- Testing
- TENS - high-dose, TENS - low-dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Knee Osteoarthritis
Wedged Orthoses and Knee Osteoarthritis
The five-year goal of this project is to investigate the effect of in-shoe wedged orthoses on lower extremity function in patients with knee osteoarthritis. In general, our aims address the long-term effects of orthoses.
- Trial name
- NCT00420147
- Testing
- wedged inshoe orthosis, neutral inshoe orthosis
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Down Syndrome
Gait in Children With Down Syndrome While Wearing Orthoses
On average, Down syndrome (DS) occurs once in every 700 live births and results in life-long disability and increased risk for comorbidities.1 Individuals with DS are also susceptible to secondary physical impairments and…
- Trial name
- NCT01598350
- Testing
- Supramalleolar Orthoses (Cascade)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Puget Sound
Stroke
Combined Cognitive and Gait Training
Recent research in gait training for stroke survivors showed that coordinated gait components can be best restored using the following interventions together: coordination exercises, over ground gait training, and body weight…
- Trial name
- CogGait (NCT02362282)
- Testing
- Gait training, cognitive training, Arm training
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development