Clinical trials: Gait Disorders
Parkinson Disease
Continuous Wearable Monitor for the Detection and Release of Freezing of Gait.
The proposed system (haptic module and insole device) for daily in-community use that detects the occurrence of freezing of gait (FOG) in people with Parkinson's disease (PD).
- Trial name
- NCT06385392
- Testing
- Haptic module and insole device
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- HealthPartners Institute
Niemann-Pick Disease, Type C
VTS-270 to Treat Niemann-Pick Type C1 (NPC1) Disease
Due to different study designs, the sponsor separated Part C into a separate registration (NCT04958642), leaving Parts A/B here in NCT02534844.
- Trial name
- NCT02534844
- Testing
- Parts A/B: Adrabetadex
- Where
- 29 sites in United States, Australia and 7 more
- Volunteers
- 56 people
- Sponsor
- Mandos LLC
Knee Osteoarthritis, Knee Pain
The Effect of AposTherapy on Knee Pain
AposTherapy is a home based exercise program utilizing footwear that causes exercise with normal activity that may significantly improve function in patients with knee osteoarthritis since patients with knee osteoarthritis have…
- Trial name
- AposKnee (NCT03171168)
- Testing
- AposTherapy, Traditional Physical Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Montefiore Medical Center
Parkinson's Disease
Laser Light Cues for Gait Freezing in Parkinson's Disease
The purpose of this study is to gather data to see if the Laser Cane and/or U-Step Walker with laser accessory is more effective in aiding with gait freezing than a regular cane/U-Step Walker in patients who have idiopathic…
- Trial name
- NCT00320242
- Testing
- 1 mo baseline before visual cue
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Beth Israel Deaconess Medical Center
Parkinson's Disease
A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease
The purpose of this study is to evaluate the effect of AMPYRA on a number of symptoms in Parkinson's disease. AMPYRA is a medication approved by FDA for gait dysfunction in multiple sclerosis.
- Trial name
- NCT01491022
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Miami
Healthy, Gait, Frontal
Optimization of Hip-exoskeleton Weight Attributes
The investigators are examining how weight distribution affects the way people walk, in terms of joint kinematics, kinetics, and muscle activity.
- Trial name
- NCT05120115
- Testing
- Weight belt
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Stroke, Gait, Hemiplegic
Gait Training Combined With Behavioral Strategies for People With Stroke
A variety of rehabilitation techniques focused on improving disability after stroke have shown significant changes on walking speed, and endurance. Also, the administration of combined techniques showed better results.
- Conditions
- Stroke, Gait, Hemiplegic, Behavior and Behavior Mechanisms
- Trial name
- NCT04546217
- Testing
- Treadmill training + transfer package (TT+TP), Treadmill training (TT)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Cerebellar Ataxia, Spinocerebellar Ataxias
Using Real-time fMRI Neurofeedback and Motor Imagery to Enhance Motor Timing and Precision in Cerebellar Ataxia
The aim of the research is to improve motor function in people with cerebellar ataxia by using neuroimaging methods and mental imagery to "exercise" motor networks in the brain.
- Conditions
- Cerebellar Ataxia, Spinocerebellar Ataxias, Cerebellar Degeneration
- Trial name
- NCT05436262
- Testing
- Real-time fMRI with neurofeedback of motor imagery
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University
Parkinson's Disease
Efficacy Study of Amantadine to Treat Gait Dysfunction and Freezing in Parkinson's Disease
The purpose of this study is to explore the efficacy of the drug Amantadine for the treatment of freezing of gait in patients with Parkinson's Disease.
- Trial name
- NCT01652534
- Testing
- Amantadine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Down Syndrome
Gait in Children With Down Syndrome While Wearing Orthoses
On average, Down syndrome (DS) occurs once in every 700 live births and results in life-long disability and increased risk for comorbidities.1 Individuals with DS are also susceptible to secondary physical impairments and…
- Trial name
- NCT01598350
- Testing
- Supramalleolar Orthoses (Cascade)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Puget Sound
Parkinson's Disease
The Effect of Donepezil on Gait and Balance in Parkinson's Disease
This study involves Parkinson's disease (PD). Symptoms include slow movement, tremor, and muscle rigidity. Current medications for the treatment of PD do not improve gait and balance difficulties in individuals with PD.
- Trial name
- NCT01521117
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
Transcranial Direct Current Stimulation (tDCS) and Parkinson's Disease
The use of low level electrical stimulation when applied over the head, also called transcranial direct current stimulation (tDCS), is being tested by several groups of researchers to see if tDCS can improve movements of persons…
- Trial name
- NCT01100762
- Testing
- Cranial Electric Stimulation (CES), Treadmill, CES and Treadmill
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Parkinson Disease
Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease
The objective of this study is to further the understanding and application of 60Hz subthalamic deep brain stimulation (STN-DBS) in Parkinson's patients with gait disorder.
- Trial name
- NCT04184791
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwell Health
Parkinson Disease
Modafinil for Freezing of Gait (FOG) in Parkinson's Disease (PD)
Freezing of gait is a late stage complication of Parkinson's disease in which patients note that their feet feel stuck or glued to the ground.
- Trial name
- NCT03083132
- Testing
- modafinil 50mg
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Arkansas
Parkinson Disease
Effect of GOCOVRI (Amantadine, Extended Release Capsules) on Gait in Parkinson's Disease
The purpose of the study is to learn about the effect of GOCOVRI (Amantadine extended release) on activity levels and measures of gait and balance quality in people with Parkinson's disease (PD) and levodopa induced dyskinesia…
- Trial name
- NCT04387773
- Testing
- GOCOVRI
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Stroke
Walk Assist Device to Improve Community Ambulation
The goal of this research study was to examine the immediate effects of a prototype wearable robotic stride management assist device (SMA) designed by Honda R\&D® on clinical walking performance, walking energetics, gait…
- Trial name
- NCT03222505
- Testing
- Honda Stride Assist Device ON, No Device Worn
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Diabetes
Vacuum Suspension: Effects on Tissue Oxygenation, Activity and Fit
The fit of the residual limb within a prosthetic socket is a primary concern for many amputees. A poor fit can lead to skin irritation, tissue breakdown, and pain.
- Conditions
- Amputation, Diabetes, Leg Injuries, Traumatic Amputations
- Trial name
- NCT00117793
- Testing
- Total Surface Bearing Suction Socket, Vacuum assisted socket system
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease
Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD
Early stage Parkinson disease (PD) is characterized by a 'honeymoon' phase in terms of responsiveness of motor symptoms, including gait, to dopaminergic pharmacotherapy.
- Trial name
- FOG (NCT03647137)
- Testing
- Detailed motor testing, including FoG, in PD subjects
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Gait Disorders
ActiveStep Comparative Effectiveness Trial
The investigators are conducting a multi-center randomized prospective trial comparing a standard physical therapy gait and balance program with a gait and balance program that includes the ActiveStep™ treadmill.
- Trial name
- RACE (NCT01006967)
- Testing
- ActiveStep Treadmill, Physical Therapy
- Where
- 8 sites in United States
- Volunteers
- 506 people
- Sponsor
- Jon D. Lurie
Stroke, Hemiplegic Gait
An Exploratory Clinical Study on a Variable Speed and Sensing Treadmill System (VASST) for Hemiparetic Gait Rehabilitation
To conduct a feasibility clinical trial to test a novel patient sensing automated treadmill device devised by local engineers for subacute hemiplegic stroke patients for gait rehabilitation.
- Trial name
- VASST (NCT01811680)
- Testing
- Variable Speed and Sensing Treadmill
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- Tan Tock Seng Hospital