Clinical trials: Galectin 3
Spinal Anesthesia
Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery
Ropivacaine is one of commonly used anesthetics for spinal anesthesia. Usually L2-3 or L3-4 intervertebral space is chosen for spinal anesthesia.
- Trial name
- NCT02565303
- Testing
- Intervertebral space, Ropivacaine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Periodontal Diseases
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases
Objectives: The aim of this study is; detection of peptidyl arginine deiminase4 (PAD4), galectin-3 and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) samples of periodontally healthy, gingivitis and…
- Trial name
- NCT04777487
- Testing
- GCF obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Ankylosing Spondylitis
Galectin-3 Level in Ankylosing Spondylitis Patients
Forty-five AS patients and 35 healthy controls were enrolled in this study. Patients diagnosed with AS according to Modified New York criteria were included in the study.
- Trial name
- NCT04746196
- Testing
- Serum galectin-3 concentration was measured.
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Idiopathic Pulmonary Fibrosis (IPF)
A Study to Test the Efficacy and Safety of Inhaled GB0139 in Subjects With Idiopathic Pulmonary Fibrosis (IPF)
This is a randomized, double-blind, placebo-controlled phase 2b trial in subjects with IPF (idiopathic pulmonary fibrosis) investigating the efficacy and safety of GB0139.
- Trial name
- NCT03832946
- Testing
- GB0139
- Where
- 128 sites in United States, Australia and 13 more
- Volunteers
- 172 people
- Sponsor
- Galecto Biotech AB
Myocarditis, Heart Failure
ARrhythmias in MYocarditis
Myocarditis promotes the occurrence of serious cardiac arrhythmias and conduction disorders which may lead to sudden cardiac death, the need for catheter ablation of arrhythmia or implantation of a cardioverter-defibrillator or…
- Conditions
- Myocarditis, Heart Failure, Endomyocardial Biopsy, Arrythmia
- Trial name
- ARMY (NCT03801681)
- Testing
- ECG holter monitoring
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Ailesel Akdeniz Ateşi
"Galectin-3 as a Marker of Subclinical Inflammation in FMF"
The goal of this observational study is to learn about the relationship between serum Galectin-3 levels and subclinical inflammation in patients with Familial Mediterranean Fever (FMF).
- Trial name
- NCT06451471
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Turkish League Against Rheumatism
Vasculitis, Systemic, Kawasaki Disease
Cardiovascular Status of Children 5 Years After Kawasaki Disease
The aim of present study is to determine cardiovascular status of children who had KD in past and to identify possible biochemical markers of cardiovascular damage in those patients.
- Trial name
- CAVASAKI (NCT03750123)
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Stable Angina
Correlational Study on the Biomarkers Application to the Prediction and Diagnosis of Cardiovascular Diseases
Through the literature review , we pick out a series of forward-looking biological indicators as follows : 1. NGAL 2. Cystatin C: 3. Galectin-3: 4. Copeptin: 5. MR-Pro ANP: 6. sST2:
- Trial name
- NCT02179047
- Testing
- coronary angiography
- Where
- Taiwan
- Volunteers
- 214 people
- Sponsor
- Taipei City Hospital
Ulcerative Colitis (UC)
The Effects of a Modified Mediterranean Diet on Ulcerative Colitis Patients
Ulcerative colitis is a chronic disease with a significant impact on quality of life where a substantial proportion of patients fails to achieve disease remission.
- Trial name
- OLIVE-UC-1 (NCT07857447)
- Testing
- Modified Mediterranean Diet, Standard Nutritional Guidance
- Where
- Croatia
- Volunteers
- 62 people
- Sponsor
- University Hospital Sestre Milosrdnice
Transthyretin Amyloidosis
New Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin Amyloidosis
The development of cardiac amyloidosis is caused by the deposition of misfolded, insoluble proteins in the extracellular matrix of tissues.
- Trial name
- NCT06345235
- Testing
- blood test
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- John Paul II Hospital, Krakow
To Measure Galectin-3 in Heart Failure Patients on Commercial Platforms
Blood Collection From Heart Failure Patients to Evaluate for Galectin-3 Measurement Differences Using Various Collection Tubes
Single-site blood collection investigation.
- Trial name
- NCT01980862
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Fujirebio Diagnostics, Inc.
Non-obstructive Azoospermia
Testicular Proteins for Sperm Retrieval Prediction Protein1, Testis-Expressed Gene 101, and Lectin Galactoside-binding Protein in Predicting Surgical Sperm Retrieval in Men With Non-Obstructive Azoospermia
Generally, azoospermia is characterized as obstructive (OA) or nonobstructive (NOA). Surgical spermatozoa retrieval results vary in success rates.
- Trial name
- Genomics (NCT06154954)
- Testing
- Semen analysis
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Atrial Fibrillation, Stroke
Galectin-3 for Thromboembolic Formation in Patients With Atrial Fibrillation CHA₂DS₂-VASc Scoring
Atrial Fibrillation is considered as one of a common cardiac arrhythmia that presented with rapid and irregular rhythm and has an increased incidence.There are different types of atrial fibrillation one of these is paroxysmal…
- Trial name
- NCT03413072
- Volunteers
- 140 people
- Sponsor
- Assiut University
Recurrent Multiple Myeloma, Refractory Multiple Myeloma
Selvigaltin With Standard of Care Treatment for the Treatment of Relapsed/Refractory Multiple Myeloma
This phase I trial studies the side effects and best dose of selvigaltin when given together with standard of care treatment (daratumumab-hyaluronidase, carfilzomib, dexamethasone) in treating patients with multiple myeloma that…
- Trial name
- NCT07082270
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute
Periodontitis, Periodontal Inflammation
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.
This study aims to evaluate gingival crevicular fluid Galectin-3 and Interleukin-1beta levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in…
- Trial name
- NCT05449093
- Testing
- Periodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Idiopathic Pulmonary Fibrosis
RCT (Randomized Control Trial) of TD139 vs Placebo in HV's (Human Volunteers) and IPF Patients
This study will be divided into 2 parts. Part 1 is a randomized, double-blind, single centre, placebo-controlled, single ascending dose (SAD) phase I study designed to assess the safety, tolerability, PK and PD (Pharmacodynamic)…
- Trial name
- NCT02257177
- Testing
- Inhaled TD139
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galecto Biotech AB
Galectin 3, Healthy Aging
G3P-01 in Volunteers With Elevated Galectin-3
G3P-01 is an investigational pectin extracted, enriched and purified from commercial squash puree intended for human consumption.
- Trial name
- Galaxy (NCT06398821)
- Testing
- G3P-01
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- General Practitioners Research Institute
Heart Failure, Cardiomyopathies
Galectin-3 Binding Protein in Cardiovascular Disease and Chronic Heart Failure
The purpose of this study is to determine whether galectin-3 binding protein plasma levels can predict adverse cardiovascular events in patients with coronary artery disease and/or heart failure.
- Conditions
- Heart Failure, Cardiomyopathies, Coronary Artery Disease
- Trial name
- GALACTIC (NCT01210157)
- Where
- Germany
- Volunteers
- 373 people
- Sponsor
- Heidelberg University
Placenta Accreta, Third Trimester
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies
Placenta Accreta Spectrum (PAS) represents a significant cause of maternal morbidity and mortality, causing complications that surpass those posed by most routine obstetric issues.
- Trial name
- NCT05945446
- Testing
- Galectin 3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Metastatic Melanoma
Peptide Vaccinations Plus GM-CT-01 in Melanoma
The purpose of this study is to determine whether the intravenous and/or GM-CT-01 administration can correct Tumor Infiltrating Lymphocytes (TIL) anergy and induce a more efficient and long-lasting anti-tumoral immune response…
- Trial name
- NCT01723813
- Testing
- Tumor specific peptides: MAGE-3.A1 and / or NA17.A2, Galectin-3 inhibitor: GM-CT-01 systemic injections, Galectin-3 inhibitor: GM-CT-01 Peri-tumoral administration
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain