Clinical trials: Gastric Acid Reflux
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Gastro-oesophageal Reflux
A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg.
- Trial name
- NCT00464308
- Testing
- Esomeprazole, Rabeprazole
- Where
- 25 sites in Australia
- Volunteers
- 1,392 people
- Sponsor
- Janssen-Cilag Pty Ltd
Pulmonary Aspiration of Gastric Contents
A Multicentre Preoperative Fasting Audit
The new European Society of Anaesthesiology and Intensive Care (ESAIC) preoperative fasting guideline recommends a one hour minimum fasting time for clear fluids.
- Trial name
- EUROFAST (NCT05519969)
- Where
- Sweden
- Volunteers
- 307,162 people
- Sponsor
- Uppsala University
Esophagitis, Reflux
Clinical Trial of Reconstruction After Proximal Gastrectomy
1) To explore a simple, safe, post-proximal gastrectomy reconstruction method with good absorption and digestive function in order to improve patients' postoperative quality of life; 2) To fill the gap in the comparison of…
- Trial name
- NCT05418920
- Testing
- left-opening single-flap technique, double-flap group technique
- Volunteers
- 250 people
- Sponsor
- Oncogastroenterology Committee of Chinese
Gastroesophageal Reflux Disorder
Efficacy and Safety of Ondansetron Versus Metaclopromide Treatment in Infants With Gastro Oesophageal Reflux
This study aimed to fill the gaps by comparing the efficacy and safety of ondansetron versus metoclopramide for the control of gastroesophageal reflux disorder in children 1-12 months of age, presenting at the outdoor department…
- Trial name
- NCT06898268
- Testing
- Metoclopramide, Ondansetron
- Where
- Pakistan
- Volunteers
- 290 people
- Sponsor
- Muhammad Aamir Latif
Gastroesophageal Reflux
Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI)
The purpose of this study is to determine the effect of vonoprazan compared to esomeprazole for preventing heartburn symptoms over a 4-week treatment period in participants who have a partial response to treatment with…
- Trial name
- NCT02743949
- Testing
- Vonoprazan, Esomeprazole
- Where
- 39 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 256 people
- Sponsor
- Takeda
Obesity, Weight Loss
Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry
The purpose of this registry study is to collect data through medical chart review and in patient visits on the efficacy and safety of various Endoscopic Bariatric therapies (EBTs).
- Conditions
- Obesity, Weight Loss, Gastro Esophageal Reflux, Bariatric Surgery Candidate
- Trial name
- EBT (NCT04494048)
- Testing
- Endoscopic Bariatric Therapies
- Where
- United States
- Volunteers
- 9,999 people
- Sponsor
- Weill Medical College of Cornell University
Esophagitis, Reflux, Esophagitis, Peptic
Efficacy and Safety of Dexlansoprazole MR and Lansoprazole on Healing of Erosive Esophagitis
The purpose of this study is to assess the efficacy and safety of 8 weeks of once-daily (QD) treatment with dexlansoprazole modified release (MR) 60 mg or 90 mg or lansoprazole 30 mg in healing subjects with endoscopically proven…
- Trial name
- NCT00251693
- Testing
- Dexlansoprazole MR, Lansoprazole
- Where
- 140 sites in United States, Australia and 13 more
- Volunteers
- 2,038 people
- Sponsor
- Takeda
Gastro Esophageal Reflux
A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-212-A in healthy subjects.
- Trial name
- NCT06025773
- Testing
- Lansoprazole 15 mg, Lansoprazole 15mg/Calcium carbonate 600mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks)
Does Pre-operative Gastric Ultrasound Influence Anaesthetic Decision-Making in Chronic Pain Patients? A Prospective Observational Cohort.
Gastric POCUS has been validated and shown to be an accurate diagnostic tool in both healthy individuals and medically complex patient populations.
- Conditions
- Gastric Ultrasound, Gastric Ultrasound in Chronic Opioid Use (≥2 Weeks), Gastric Ultrasound in Poorly Controlled Acute-on-chronic Pain, Gastric Ultrasound in Acute Opioid Administration Within 24 Hours Prior to the Procedure
- Trial name
- NCT07537582
- Where
- United Arab Emirates
- Volunteers
- 140 people
- Sponsor
- Danat Al Emarat Hospital
Clinically Severe Obesity, Gastroesophageal Reflux Disease
Gastric Bypass After Previous Anti-reflux Surgery
The goal of this study is to describe the clinical presentation, indications, and operative treatment as well as assess the morbidity, mortality, and overall performance of revisional Roux-en-Y gastric bypass (RYGB) after either…
- Trial name
- RYGBafterARS (NCT01041105)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Stomach Neoplasms, Esophageal Neoplasms
Impact of Gastric Tube Reconstruction Widths on Quality of Life for Esophagogastric Cancers
The incidence of cancer of the esophagogastric junction has rapidly risen in recent three decades, and surgery still remains the optimum therapy.
- Trial name
- NCT01911832
- Testing
- esophagojejunostomy after total gastrectomy, Roux-en-Y gastrojejunostomy after subtotal gastrectomy, wide tube reconstruction after subtotal gastrectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Esophagitis, Reflux, Esophagitis, Peptic
Comparison of Dexlansoprazole MR to Placebo on the Ability to Maintain Healing in Subjects With Healed Erosive Esophagitis
The purpose of this study is to assess the ability of once-daily (QD) treatment with Dexlansoprazole modified-release (MR) 60 mg and 90 mg and placebo in maintaining healing of erosive esophagitis (EE).
- Trial name
- NCT00255151
- Testing
- Dexlansoprazole MR
- Where
- 100 sites in United States
- Volunteers
- 451 people
- Sponsor
- Takeda
Oesophageal Reflux, Gastric Reflux
Efficacy and Speed of Action of a Product to Control Gastric Hydration and Gastroesophageal Reflux
A Randomised, Placebo-Controlled Clinical Trial off the Efficacy and Rapidity of Action of a Product Containing Sodium Alginate, Calcium and Magnesium Salts, Hyaluronic Acid and Aloe Vera to Control Oesophageal-Gastric pH and…
- Conditions
- Oesophageal Reflux, Gastric Reflux, Hyperactivity; Stomach
- Trial name
- AQUAA (NCT05060744)
- Testing
- Antacid, Control
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Uriach Consumer Healthcare
Achalasia, Paraesophageal Hernia
Minimally Invasive Surgery of the Gastro-esophageal Junction
This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ).
- Conditions
- Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula
- Trial name
- MISGEJ (NCT01799967)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Anti-Reflux Alimentary Reconstruction, Laparoscopic Proximal Gastrectomy
A 3-Arm Study Comparing the Efficacy of Anti-Reflux Reconstruction Protocols After Laparoscopic Proximal Gastrectomy
The efficacy of three different alimentary reconstruction methods after proximal gastrectomy will be investigated in this study in a prospective, multicenter, randomized controlled trial.
- Conditions
- Anti-Reflux Alimentary Reconstruction, Laparoscopic Proximal Gastrectomy, Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction
- Trial name
- NCT06347757
- Testing
- Anti-Reflux Alimentary Reconstruction After Laparoscopic Proximal Gastrectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Northern Jiangsu People's Hospital
Gastrectomy, Obesity
Endoscopic vs. Suction Device Calibration in Sleeve Gastrectomy
This study aims to compare the difference in staple usage and post-operative GERD (heartburn) between patients that had an endoscope used versus patients that had a suction calibration system used on them during "laparoscopic…
- Trial name
- NCT03939819
- Testing
- ViSiGi® 3D suction calibration device, Esophagogastroduodenoscopy (EGD) calibration
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Emory University
Gastric Content Aspiration
GLP-1 Receptor Agonist Use and Incidence of Retained Gastric Food on Endoscopy
This study will enroll patients ages 18 and over who are in one of the following groups 1) taking a GLP-1 receptor agonist medication 2) not taking a GLP-1 receptor agonist (control group), are undergoing EGS and have…
- Trial name
- NCT05875636
- Testing
- Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Medical University of South Carolina
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Anesthesia, Gastric Ultrasound
Gastric Emptying Time in Traumatic Injuries
The investigators plan to do serial sonographic examinations of the gastric antrum (quantity, quality) to estimate the gastric emptying time and dependant factors after traumatic injurys.
- Conditions
- Anesthesia, Gastric Ultrasound, Sonography, Point of Care Ultrasound (POCUS)
- Trial name
- NCT06643325
- Testing
- Gastric ultrasound
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Kantonsspital Winterthur KSW