Clinical trials: Gastric Bypass
Hypoglycemia Non-Diabetic, Gastric Bypass Surgery
Glucose Monitoring in Treatment of Postprandial Hypoglycemia After Gastric Bypass Surgery
The goal of this clinical trial is to learn if continuous glucose monitoring works to treat postprandial hypoglycaemia in patients who have undergone gastric bypass surgery.
- Trial name
- HypoSurge (NCT06468865)
- Testing
- Continuous glucose monitor (Dexcom® G7)
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sykehuset i Vestfold HF
Gastric Cancer, Gastric Outlet Obstruction
Stomach-Partitioning Versus Conventional Gastrojejunostomy for Malignant Gastric Outlet Obstruction: A Multicenter Randomized Controlled Trial
Gastric outlet obstruction (GOO) complicates locally advanced or metastatic gastric cancer and severely impairs oral intake, nutritional status, and quality of life.
- Trial name
- NCT07561073
- Testing
- stomach-partitioning gastrojejunostomy, conventional gastrojejunostomy
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Guangxi Medical University
Type 2 Diabetes, Obesity
Changes in Incretins Response and Glycemic Control After Gastric Bypass Surgery in Type 2 Diabetic Patients Versus Healthy
The purpose of this study is to determine the early changes in gut hormonal, and other metabolites with known relations to the glycemic homeostasis.
- Trial name
- NCT01820273
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lund University
Obesity & Overweight, Bariatric Surgery
Rosuvastatin and Losartan Pharmacokinetics After Bariatric Surgery
This prospective, open-label, non-randomized pharmacokinetic study will evaluate how Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy affect systemic exposure to single oral test doses of rosuvastatin and losartan.
- Conditions
- Obesity & Overweight, Bariatric Surgery, Pharmacokinetics After Oral Intake, Drug Absorption
- Trial name
- BARI-PK (NCT07748273)
- Testing
- Rosuvastatin, Losartan (Control)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Obesity
Exendin-9,39 and Satiety After Bariatric Surgery
The overall aim of the application is to determine the contribution of the elevated incretin hormone concentrations seen after certain types of bariatric surgery to the regulation of food intake and satiety.
- Trial name
- NCT02779075
- Testing
- Saline, Exendin-9,39
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Diabetes Mellitus, Type 2
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02710370
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Morbid Obesity
Early Feasibility for Safety & Device Functionality of SFM Anastomosis Device Used in 3 Procedures (SNAP-S) or (SNAP-PS) or (J-J)
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a duodenal-ileal (D-I) anastomosis either during sleeve…
- Trial name
- GIW-SFM (NCT06199635)
- Testing
- Self-Forming Magnetic Anastomosis Device and Delivery System
- Where
- 2 sites in Chile, India
- Volunteers
- 28 people
- Sponsor
- GI Windows, Inc.
Obesity
Bariatric Surgery Telemedicine Study
The purpose of this study is to evaluate a new educational program for people who have recently had gastric bypass surgery. This program involves both the use of newly developed wireless home monitoring technology (medication…
- Trial name
- NCT01378897
- Testing
- MedSignals®pillbox,Omron pedometer,VitalSignals®weight scale
- Where
- United States
- Sponsor
- Baystate Medical Center
Type 2 Diabetes
The Importance of GLP-1 in Post RYGB Improvement in Glycaemic Control Type 2 Diabetic Subjects
After Roux-en-Y gastric bypass (RYGB) meal induced GLP-1 secretion is dramatically increased, while beta-cell function is increased in type 2 diabetic (T2D) subjects.
- Trial name
- NCT01579981
- Testing
- Roux-en-Y Gastric Bypass
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Hvidovre University Hospital
Internal Hernias
Internal Hernias After Gastric Bypass Can be Prevented Safely With Primary Closure of All Mesenteric Defects With Clips
The purpose of this study is to determine whether closure of all mesenteric defects with clips at the time of Gastric bypass, can avoid the complication of late bowel obstruction- internal hernias
- Trial name
- NCT01595230
- Testing
- Closing the mesenteric defects with clips during opration
- Where
- 2 sites in Denmark
- Volunteers
- 405 people
- Sponsor
- Region Zealand
Obesity, Morbid, Weight Loss
"Tailored" Bilio-Pancreatic Limb Length and Weight Loss After Mini-Gastric Bypass
Retrospective review of prospectively collected blinded patient data. To Address simple question: In cases of Mini-Gastric Bypass performed using the Original Technique what (if any) is the relation between the Bilio-pancreatic…
- Conditions
- Obesity, Morbid, Weight Loss, Bariatric Surgery Candidate, Power
- Trial name
- BplVsWtLoss (NCT04440306)
- Testing
- Mini-Gastric Bypass - Original Technique
- Where
- India
- Volunteers
- 191 people
- Sponsor
- Kular Hospital
Morbid Obesity, Opioid Use
Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Anesthetic agents, including opioids can modulate the altered immune function in patients with obesity through mechanisms that involve the expression and release of cytokines.
- Conditions
- Morbid Obesity, Opioid Use, Fentanyl Adverse Reaction, Cytokine Storm
- Trial name
- NCT04854252
- Testing
- Fentanyl
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- University of Guadalajara
Diabetes Mellitus, Obesity
Single Loop DJB Sleeve Gastrectomy for Poorly Controlled T2DM
Type 2 diabetes mellitus (T2DM) is a chronic progressive illness affecting a substantial percentage of the general population. While pharmacotherapy remains the mainstay of treatment, around 60% of patients cannot achieve the…
- Conditions
- Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT03125369
- Testing
- Sleeve gastrectomy + duodeno-jejunal bypass, Roux-Y gastric bypass
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes, Obesity
Changes in Glucose Metabolism After Roux-en-Y Gastric Bypass
Besides causing weight loss Roux-en-Y gastric bypass (RYGB) has profound effect on glucose metabolism leading to remission of type 2 diabetes early after surgery. However the mechanisms for this improvement remain uncertain.
- Trial name
- NCT01993511
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Morbid Obesity
Comparison of Mini Gastric Bypass and Roux-en-Y Gastric Bypass
This study compares Roux-en-Y gastric bypass with single anastomosis gastric bypass in a randomized prospective setting. This study also adresses the issue of bile reflux after MGB.
- Trial name
- RYSA (NCT02882685)
- Testing
- Roux-en-y gastric bypass, Single anastomosis gastric bypass
- Where
- 2 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Type 2 Diabetes Mellitus
The Contribution of Incretin Hormones to the Amelioration of Glucose Metabolism After Roux-en-Y Gastric Bypass
The study is being undertaken to understand how a gastric bypass can affect a subject's diabetes even prior to their losing significant amounts of weight.
- Trial name
- NCT01843855
- Testing
- Exendin 9,39
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Adrian Vella
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Type2 Diabetes, NAFLD
Effects of VLCD and Bariatric Surgery in Patients With Type 2 Diabetes
The investigators are therefore interested to explore the effects of VLCD and different bariatric surgery procedures to changes in the physical deposition of fat in organs which regulate glucose metabolism (i.e.
- Conditions
- Type2 Diabetes, NAFLD, Obesity
- Trial name
- BARIATRICMRI (NCT05092399)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Diabetes Mellitus, Type 2, Insulin Resistance
New Frontiers on Bariatric Surgical Procedures: Classical Bypass for Type-2 Diabetic Patients With Obesity Grade I
Bariatric surgery leads to remission of type 2 diabetes in morbid obese patients in 80% (Roux-en-Y gastric bypass)to 90% (biliopancreatic diversion and duodenal switch) of cases.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566189
- Testing
- Roux-en-Y Bypass Gastroplasty
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- University of Campinas, Brazil
Liver Diseases
Hepatic Effects of Gastric Bypass Surgery
Liver disease in the morbidly obese is thought to occur due to the long-term presence of fat deposits in the liver, resulting in inflammation and scarring of the liver over time, which reduces liver function.
- Trial name
- NCT00701376
- Testing
- liver biopsy
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- The Cleveland Clinic