Clinical trials: Gastric Bypass
Obesity
Cerebrospinal Fluid Biomarkers in Bariatric Surgery
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms.
- Trial name
- NCT04350892
- Testing
- Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Very Low Calorie Diet (VLCD)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Columbia University
Gastric Emptying, Roux-en-Y Gastric Bypass
Bariatric Procedures and Changes Gastric Passage
Gastric emptying measured with scintigraphy in patients after standard Roux-en-Y Gastric Bypass (S-RYGB), Banded-RYGB (B-RYGB) or Extended pouch-RYGB (E-RYGB).
- Conditions
- Gastric Emptying, Roux-en-Y Gastric Bypass, Bariatric Surgery
- Trial name
- BIP (NCT04972357)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Rijnstate Hospital
Post-bariatric Hypoglycaemia, Roux-en-Y Gastric Bypass
Forecasting and Preventing Post-Bariatric Hypoglycaemia WP 1
The overall aim of this study is to prevent hypoglycemic events in patients with hypoglycemia after a meal and to develop a sustainable hypoglycemia correction strategy.
- Trial name
- PBH Forecast (NCT05212207)
- Testing
- CGM, smartwatch, and electronic diary
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Lia Bally
Pain, Postoperative Pain
REduced Pain After Bariatric Surgery - Gastric Bypass
This study aims to analyze the effect of laparoscopic guided transversus abdominis plane (LG-TAP) block compared to placebo for postoperative analgesia following laparoscopic gastric bypass.
- Conditions
- Pain, Postoperative Pain, Acute Pain, Analgesia
- Trial name
- REPABS-BPG (NCT06614257)
- Testing
- LG-TAP block with local anesthetic, Port site infiltration, LG-TAP block with saline solution
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Ulcer, Gastric, Bile Reflux
Evaluation of Biliary Reflux After Mini-gastric Bypass With Using the Biliary Reflux Index
MGB is considered to be the best alternative to Roux-en-Y gastric bypass (RYGB) due to the shorter operation time and fewer possible complications.
- Trial name
- NCT04845438
- Testing
- fibrogastroscopy, biopsy of the gastric mucosa, microscopy biopsy materials, using Bile Reflux Index
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Private Healthcare Institution Clinical Hospital RGD-Medicine
Post-bariatric Surgery
The Effect of Supervised Exercise on Physical Fitness and Energy Expenditure in Post Bariatric Surgery Patients
It is hypothesized that the patients in the EXDA group will be able to complete a structured exercise program at a level sufficient to accumulate at least 2000 kcal per week, and that the structured endurance activity will…
- Trial name
- NCT00793832
- Testing
- supervised exercise, Diet advice
- Volunteers
- 33 people
- Sponsor
- University of Texas Southwestern Medical Center
Obesity & Overweight, Bariatric Surgery
Rosuvastatin and Losartan Pharmacokinetics After Bariatric Surgery
This prospective, open-label, non-randomized pharmacokinetic study will evaluate how Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy affect systemic exposure to single oral test doses of rosuvastatin and losartan.
- Conditions
- Obesity & Overweight, Bariatric Surgery, Pharmacokinetics After Oral Intake, Drug Absorption
- Trial name
- BARI-PK (NCT07748273)
- Testing
- Rosuvastatin, Losartan (Control)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital das Clínicas de Ribeirão Preto
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Gastric Bypass
Mini Gastric Bypass vs Roux enY Gastric Bypass
The primary aim of this research project is to assess the safety and efficacy of the MGB operation in the UK
- Trial name
- MGB vs RYGB (NCT03673969)
- Testing
- Gastric bypass
- Where
- United Kingdom
- Sponsor
- Doncaster And Bassetlaw Hospitals NHS Foundation Trust
Gastroesophageal Reflux Disease, Morbid Obesity
Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass
The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.
- Trial name
- NCT00951093
- Testing
- Gastric bypass
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinica Gastrobese
Gastroesophageal Reflux Disease
Transoral Fundoplication Prior to Sleeve Gastrectomy Versus RNY Gastric Bypass on GERD Symptoms in Bariatric Patients
A retrospective and prospective cohort study to compare the effect of completing a Transoral Fundoplication procedure prior to Laparoscopic Sleeve Gastrectomy surgery to Laparoscopic Roux-en-Y Gastric Bypass in bariatric patients…
- Trial name
- NCT05365087
- Testing
- Transoral Fundoplication and Sleeve Gastrectomy, Gastric Bypass
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Lexington Health Incorporated
Superior Mesenteric Artery Syndrome, Duodenal Obstruction
Comparison of One Anastomisis Gastric Bypass and Duodeno-Jejunostomy for Treating SMA Syndrome
The goal of this clinical trial is to find out which surgery works better to treat people with a rare condition called Superior Mesenteric Artery Syndrome (SMAS).
- Conditions
- Superior Mesenteric Artery Syndrome, Duodenal Obstruction, Weight Loss, Gastrointestinal Disease
- Trial name
- NCT06970093
- Testing
- One Anastomosis Gastric Bypass, Duodenojejunostomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2
Management of Type 2 Diabetes After Gastric Bypass Surgery
Gastric bypass surgery has been proposed as an effective treatment strategy for type 2 diabetes mellitus (T2DM), but thus far algorithms for the management of T2DM immediately after surgery have not been established.
- Trial name
- NCT01213563
- Testing
- Actrapid insulin+Gloucose, Actrapid insulin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Post-operative Pain Management
Efficacy of Exparel (TM) on Post-operative Pain After Laparoscopic Gastric Bypass Using Circular EEA Stapler
This will be a comparative study between two cohorts of patients undergoing Roux-en-Y Gastric bypass. One cohort (75 patients) will receive FDA approved Exparel® (liposome bupivacaine injection solution) injections…
- Trial name
- NCT03187379
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Matthew Kroh
Observational
Stapler Post-market Observational Study
The purpose of this observational study is to evaluate the safety and performance of the Endoscopic Linear Cutter Stapler and reloads from Fengh Medical used in laparoscopic Roux-en-Y gastric bypass surgery to create anastomoses.
- Trial name
- NCT02922205
- Testing
- Endoscopic Linear Cutter Stapler and reloads
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Duomed
Laparoscopic-Roux-en-Y Gastric Bypass, Obesity
Gastric Bypass With Different Lengths of the Bilipancreatic Limb
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) has been the most performed bariatric surgical intervention until a few years ago, due to its good results in terms of weight loss and remission of comorbidities such as hypertension…
- Conditions
- Laparoscopic-Roux-en-Y Gastric Bypass, Obesity, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- BPG-1 (NCT05334173)
- Testing
- Roux-en-Y Gastric Bypass (RYGB) measuring the lengh of the common limb
- Where
- 3 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Hospital Universitario de Fuenlabrada
Obesity & Overweight
Scannographic Predictive Factors of Change of Strategy During Metabolic Bariatric Surgery
Background: Laparoscopic Roux-en-Y Gastric By-pass (LRYGB) is not always feasible due to intraoperative difficulties, necessitating a change during surgical procedure.
- Trial name
- SCANOBE (NCT07296224)
- Where
- France
- Volunteers
- 288 people
- Sponsor
- Central Hospital, Nancy, France
Morbid Obesity
SAS-J Compared to OAGB and LSG as a Treatment for Morbid Obesity
150 morbidly obese patients divided into to equal groups, group A underwent single anastomosis sleeve jejunal bypass and group B underwent mini gastric bypass, group C underwent sleeve gastrectomy.
- Trial name
- NCT03821688
- Testing
- SAS-JB, OAGB, LSG
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Minia University
Morbid Obesity, Obesity
TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass
This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity.
- Trial name
- TSBL-OAGB (NCT07796503)
- Testing
- TSBL-based biliopancreatic limb length determination, BMI-based biliopancreatic limb length determination
- Where
- Kazakhstan
- Volunteers
- 100 people
- Sponsor
- National Scientific Center of Surgery named after A.N.Syzganov
Diabetes, Bariatric Surgery
Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care
This study is a randomized trial that evaluates the effect of metformin addition or not to standard care on the duration of diabetes remission after bariatric surgery.
- Conditions
- Diabetes, Bariatric Surgery, Metformin
- Trial name
- DiabOUT (NCT04581447)
- Testing
- Metformin, Standard Care, Standardized meal
- Where
- 16 sites in France
- Volunteers
- 126 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris