Clinical trials: Gastric Bypass
Morbid Obesity
Early Feasibility for Safety & Device Functionality of SFM Anastomosis Device Used in 3 Procedures (SNAP-S) or (SNAP-PS) or (J-J)
The objectives of this study are to assess the initial safety and device functionality of the SFM Anastomosis System including delivery systems when used to create a duodenal-ileal (D-I) anastomosis either during sleeve…
- Trial name
- GIW-SFM (NCT06199635)
- Testing
- Self-Forming Magnetic Anastomosis Device and Delivery System
- Where
- 2 sites in Chile, India
- Volunteers
- 28 people
- Sponsor
- GI Windows, Inc.
Hypoglycemia, Reactive
Pasireotide in the Treatment of Hypoglycemia Following Gastric Bypass Surgery
Postprandial hyperinsulinemic hypoglycemia is a well-known and potentially severe complication of Roux-en-Y gastric bypass (RYGB), and the treatment options are limited.
- Trial name
- NCT03514576
- Testing
- Pasireotide 0.3 MG/ML, Meal tolerance test (MTT)
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- Zealand University Hospital
Overweight
Carbohydrates and Gut Hormones After Gastric Bypass Surgery
To investigate the secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1), after ingestion of glucose and fructose as separate monosaccharides or combined in the disaccharides sucrose and isomaltulose and the…
- Trial name
- NCT02879955
- Testing
- Glucose + Fructose, Sucrose, Isomaltulose
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Weight Loss
RYGB AL 150cm BPL 100cm vs RYGB AL 100cc BPL 150cm
A Roux-en-Y gastric bypass will be performed in all the cases. Patients will be randomized according the limb lengths: Group 1: Alimentary limb (AL) 150cm and biliopancreatic limb (BPL) 100cm Group 2: AL 100cm and BPL 150cm…
- Trial name
- NCT03838276
- Testing
- AL 150 BPL100, AL 100 BPL 150
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Elche
Obesity, Morbid
Omega Gastric Bypass (150cm) Compared to the Roux-en-Y Gastric Bypass (YOMEGA-2 Multicentric Trial)
Obesity with its consequences such as type 2 diabetes, high blood pressure, dyslipidemia, fatty liver disease, sleep apnea and cancers, remains a major healthcare problem worldwide.
- Trial name
- YOMEGA-2 (NCT06057597)
- Testing
- Laparoscopic OAGB, Laparoscopic RYGB
- Where
- France
- Volunteers
- 368 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bariatric Surgery
MINI Bypass Versus Roux-en-Y Bypass: Differences in HOrmonal Secretions at 2 Years of Surgery
Gastric bypass with omega loop technic (OLGB) seems to be as effective as gastric bypass roux-en-Y (RYGB the reference) for the management of obesity and type 2 diabetes, but with less early surgical complications and more…
- Trial name
- MINIBHO (NCT03482895)
- Testing
- Blood sampling, Feces sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Meal, Obesity, Morbid
Microstructural Analysis of Ingestive Behavior After Roux-en-Y Gastric Bypass - Pilot
The ability to assess ingestion in fine detail over the time course of a liquid meal allows for comparison of early and late meal features of drinking and may help dissociate manipulations (surgical, neural, pharmacological…
- Conditions
- Meal, Obesity, Morbid, Food Deprivation, Bariatric Surgery
- Trial name
- NCT03747445
- Testing
- Roux-en-Y gastric bypass
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marco Bueter
Obesity, Morbid
Different Limb Lengths in Gastric Bypass Surgery (SLIM) - Part 3: Metabolism and Inflammation
Investigation of underlying metabolic mechanisms and impact on the two surgical procedures on inflammatory factors.
- Trial name
- SLIM - Part 3 (NCT05471037)
- Testing
- Long Biliopancreatic Limb LRYGB, Short Biliopancreatic Limb LRYGB
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery.
The primary goal of the study is to determine if orlistat 60mg (Alli) is effective in helping patients achieve a required 10% weight loss goal prior to bariatric surgery.
- Trial name
- NCT01035333
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Albany College of Pharmacy and Health Sciences
Obesity
Omega Loop Versus Roux-en-Y Gastric Bypass
Several prospective trials and metaanalysis have demonstrated the superiority of bariatric surgery on the medical treatment of obesity.
- Trial name
- YOMEGA (NCT02139813)
- Testing
- Laparoscopic Mini-gastric bypass, Procedure of reference in bariatric surgery
- Where
- 9 sites in France
- Volunteers
- 256 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Bariatric Surgery
Swap Anesthetic Versus Continuous Desflurane in Adults Undergoing Bariatric Surgery
This randomized, parallel-group, non-inferiority clinical trial aims to evaluate whether an anesthetic swap strategy consisting of sevoflurane followed by desflurane 30 minutes before the end of surgery is non-inferior to…
- Trial name
- SWAP (NCT07748247)
- Testing
- Desflurane, Sevoflurane-Desflurane
- Where
- Chile
- Volunteers
- 82 people
- Sponsor
- Clínica Dávila
Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone
Randomized Trial Comparing Gastric Bypass With and Without Cholecystectomy
The main objective of this pilot study is to show feasibility to collect peri-operative and postoperative clinical data of the study group of gastric bypass without cholecystectomy compared with the control group of gastric…
- Conditions
- Roux-en-Y Gastric Bypass, Cholecystitis; Gallstone, Gallbladder Diseases
- Trial name
- NCT04324515
- Testing
- Robotic gastric bypass with or without cholecystectomy
- Where
- Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Geneva, Switzerland
Gastric Bypass Surgery Pain Management
Transcranial Magnetic Stimulation Effects on Pain Perception
The purpose of this research study is to investigate the effects of Transcranial Magnetic Stimulation on pain perception. TMS is a non - invasive technique that uses electromagnetic pulses to temporarily stimulate specific brain…
- Trial name
- TMS (NCT01861574)
- Testing
- Real TMS 45 min, Real TMS 4 Hours
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Medical University of South Carolina
Type 2 Diabetes
Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID)
This research study will investigate the safety and effectiveness of weight loss surgery for overweight persons with type 2 diabetes.
- Trial name
- SOLID (NCT01040468)
- Testing
- Roux-en-Y Gastric Bypass surgery, Laparoscopic Adjustable Gastric Banding surgery, Intensive Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Bariatric Surgery, Gastric Bypass
Study to Examine the Effect of Gastric Bypass Surgery on Venlafaxine ER Blood Levels
The purpose of the study is to determine whether a significant and predictable change in bioavailability of extended-release venlafaxine occurs following Roux-en-Y gastric bypass.
- Conditions
- Bariatric Surgery, Gastric Bypass, Roux-en-Y Gastric Bypass
- Trial name
- NCT01867255
- Testing
- venlafaxine ER (extended-release) 75 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Obese Patients, Obese Patients With Bariatric Surgery
Bariatric Surgery and Gut Microbiota Changes Over Time
The goal of this observational study is to learn how bariatric surgery affects gut bacteria and gut-related metabolic products over time in adults with obesity.
- Conditions
- Obese Patients, Obese Patients With Bariatric Surgery, Gut Microbiota, Healthy Participants
- Trial name
- RYGB-MICROGUT (NCT07381140)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Gastric Bypass Surgery
The Effects of Probiotic Supplementation on the Results of Gastric Bypass Surgery
In this study, patients undergoing the bariatric surgery will be assigned to take either probiotic capsules or placebos from 1 month before surgery to 3 months after the surgery.
- Trial name
- NCT02708589
- Testing
- probiotic
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- National Nutrition and Food Technology Institute
Obesity, Morbid, Surgery
Indocyanine Green Test in Bariatric Surgery
Indocyanine green (ICG) can be injected into the human bloodstream and it allows us to show stomach vascularity in real time
- Conditions
- Obesity, Morbid, Surgery, Leak, Anastomotic
- Trial name
- NCT05476159
- Testing
- Indocyanine green solution, Gastric bypass
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Hypoglycemia, Gastric Outlet Obstruction
Endoscopic Ultrasound-guided Large Diameter Lumen-apposing Metal Stent Gastro-gastrostomy for Bypass Reversal in Patients With Roux-en-y Gastric Bypass
The primary objective of this open-label pilot study is to investigate whether an endoscopically placed lumen apposing metal stent is an effective alternative to surgery in patients that have a clear indication for reversal of…
- Conditions
- Hypoglycemia, Gastric Outlet Obstruction, Steatohepatitis, Parenteral Support
- Trial name
- LABOR (NCT05640947)
- Testing
- The Hot AXIOS™ Stent and Electrocautery-Enhanced Delivery System
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Gastric Bypass, Obesity
Meal Stimulating After Roux-en Y Gastric Bypass
In many studies, gastric bypass surgery led to total remission of type 2 diabetes (T2DM) as early as 1 - 2 days after surgery before any real weight loss has occurred.
- Trial name
- NCT00915980
- Testing
- gastric bypass surgery and testing
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital