Clinical trials: Gastric Bypass
Gastric Bypass, Body Weight
Pharmacokinetic Evaluation of Moxifloxacin Administered Intravenously and Orally in Healthy Volunteers Who Have Had a Gastric Bypass
Roux-and-Y gastric bypass is one of the most common forms of bariatric surgery; due to a reduction in size of the stomach and intestine, the available surface area for the absorption of oral drugs is strongly decreased.
- Trial name
- DRUG10_MOXI (NCT01130922)
- Testing
- moxifloxacin per IV, moxifloxacin per os
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Ghent
Hypothermia, Morbid Obesity
The Efficacy of External Warming During Laparoscopic Bariatric Surgery
External warming is routinely used in general surgery to offset the deleterious effects of hypothermia. It entails deployment of a disposable, external heating blanket attached to a regulated hot-air pump.
- Conditions
- Hypothermia, Morbid Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03429205
- Testing
- No external heating used during surgery, External heating blanket used during surgery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Morbid Obesity
Changes in Ingestive Behaviour Following Gastric Bypass
The gastric bypass procedure is known to be one of the most successful treatments for morbid obesity and Type 2 diabetes mellitus, and has been shown to decrease appetite, energy intake, body weight and glycemia both in the short…
- Trial name
- NCT03113305
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Weight Loss
Impact of Biliopancreatic Limb Lenght on Long-term Weight Loss After Roux-en-Y Gastric Bypass
Patients were randomly assigned into 2 groups: those patients undergoing RYGB with a BPL of 70cm and those ones undergoing RYGB with a BPL of 120 cm. Excess BMI loss 5 years after surgery was investigated
- Trial name
- NCT03607305
- Testing
- BP limb 70cm, BP limb 120cm
- Volunteers
- 506 people
- Sponsor
- Hospital General Universitario Elche
Morbid Obesity
The Influence of Aerobic Endurance Training After Roux-en-Y-Gastric Bypass
The aim of this study was to assess the efficiency of aerobic physical exercise (APE) on weight loss, body composition and co-morbidities in patients after laparoscopic Roux-en-Y Gastric bypass (RYGBP).
- Trial name
- AET (NCT00875186)
- Testing
- aerobic endurance training
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Small Gestational Age (SGA), Hypoglycemia After Gastric Bypass
Glycemic Variability During Pregnancy After Bariatric Surgery
Pregnancies after Metabolic and Bariatric Surgery (MBS) are linked to increased incidence of small-for-gestational-age (SGA) neonates.
- Conditions
- Small Gestational Age (SGA), Hypoglycemia After Gastric Bypass, Glycemic Variability
- Trial name
- NCT07731165
- Testing
- Intermittently Scanned Continuous Glucose Monitoring (isCGM)
- Where
- Portugal
- Volunteers
- 47 people
- Sponsor
- Centro Hospitalar Universitário de Santo António
Metabolic and Bariatric Surgery
Tailored One Anastomosis Gastric Bypass
One Anastomosis Gastric Bypass (OAGB) is the most common metabolic and bariatric surgery (MBS) in Israel, recognized for its effectiveness in achieving sustainable weight loss and mitigating obesity-related diseases.
- Trial name
- OAGB-TL (NCT06829381)
- Testing
- Tailored BPL length, Control - BPL 180 cm
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gastric Bypass, Parathyroid Hormone
Trial Of Paricalcitol and Cholecalciferol(Vitamin D3) in the Treatment Of Secondary Hyperparathyroidism in Patients After ROUX-EN-Y Gastric Bypass Surgery
Evaluate the efficacy of paricalcitol, cholecalciferol, and placebo in the reduction of parathyroid hormone in patients after Roux-en-Y gastric bypass surgery (RYGB).
- Trial name
- ExtenD (NCT01138475)
- Testing
- Paricalcitol, Cholecalciferol
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Kerstyn C. Zalesin, M.D.
Pain, Postoperative Pain
REduced Pain After Bariatric Surgery - Gastric Bypass
This study aims to analyze the effect of laparoscopic guided transversus abdominis plane (LG-TAP) block compared to placebo for postoperative analgesia following laparoscopic gastric bypass.
- Conditions
- Pain, Postoperative Pain, Acute Pain, Analgesia
- Trial name
- REPABS-BPG (NCT06614257)
- Testing
- LG-TAP block with local anesthetic, Port site infiltration, LG-TAP block with saline solution
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Morbid Obesity
Effect of Number of Meals on Metabolism After Weight Loss Surgery
The purpose of this study is to determine the effect of meal size and texture on the levels of incretin hormone, GLP-1, after Gastric Bypass Surgery (GBP).
- Trial name
- LAF 28 (NCT02929212)
- Testing
- Solid Meal, Liquid Meal, Acetaminophen
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Columbia University
Severe Obesity
Bypass Equipoise Sleeve Trial (BEST)
This is nationwide registry-based randomised clinical multicenter trial in which patients will be randomised to gastric bypass (RYGB) or sleeve gastrectomy (SG).
- Trial name
- BEST (NCT02767505)
- Testing
- gastric bypass, Sleeve gastrectomy
- Where
- 21 sites in Norway, Sweden
- Volunteers
- 1,752 people
- Sponsor
- Göteborg University
Gastric Outlet Obstruction, Pancreatic Cancer
Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy
The aim of this observational study is to compare the outcomes of three different procedures performed for the management of malignant Gastric Outlet Obstruction due to Pancreatic Cancer.
- Trial name
- GOOSE (NCT06071507)
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Obesity, Morbid, Metabolic Syndrome
Non-randomized Prospective Comparison Between SASI Bipartition and RYGB
The main aim of this project is to assess the safety and efficiency of the SASI Bipartition.
- Conditions
- Obesity, Morbid, Metabolic Syndrome, Bariatric Surgery Candidate, Postoperative Complications
- Trial name
- NCT04469712
- Testing
- SASI Bipartition, Gastric bypass
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- Aleris Hospital
Laparoscopic-Roux-en-Y Gastric Bypass, Obesity
Gastric Bypass With Different Lengths of the Bilipancreatic Limb
Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) has been the most performed bariatric surgical intervention until a few years ago, due to its good results in terms of weight loss and remission of comorbidities such as hypertension…
- Conditions
- Laparoscopic-Roux-en-Y Gastric Bypass, Obesity, Diabetes Mellitus, Type 2, Hypertension
- Trial name
- BPG-1 (NCT05334173)
- Testing
- Roux-en-Y Gastric Bypass (RYGB) measuring the lengh of the common limb
- Where
- 3 sites in Spain
- Volunteers
- 94 people
- Sponsor
- Hospital Universitario de Fuenlabrada
Obesity, Bariatric Surgery Candidate
Diet-induced Thermogenesis in Patients With Postoperative Roux-in-Y Gastric Bypass (RYGBP) Weight Regain
Introduction: According to the National Health and Nutrition Examination Survey 2009-2010, 78 million American adults are obese.
- Conditions
- Obesity, Bariatric Surgery Candidate, Protein-energy; Imbalance
- Trial name
- RYGBP (NCT02422212)
- Testing
- patients eat a mixed solid meal
- Where
- 3 sites in Brazil
- Volunteers
- 45 people
- Sponsor
- Silvia Leite Faria
Obesity, Outpatient Surgery
The Same-Day and One Day Gastric Bypass by Use the "FundoRing" Method (Same-Day_FundoRing Trial)
Outpatient surgery means that patient have surgery and often go home the same day. Safety and utilization outcomes were similar between outpatient and inpatient bariatric surgery, and outpatient was associated with shorter…
- Conditions
- Obesity, Outpatient Surgery, Same-Day Surgery
- Trial name
- NCT07189416
- Testing
- Laparoscopic One Anastomosis Gastric Bypass by Use the "FundoRing" method with Enhanced Recovery Protocol and Remote Monitoring in Ambulatory Surgery Center with Integrated Apartments
- Where
- Kazakhstan
- Volunteers
- 200 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Obesity, Morbid, Gastric Bypass
Effects of Gastric Bypass Surgery and Calcium Metabolism and the Skeleton
Obesity is a chronic illness of staggering proportions. Because weight loss through diet and exercise is difficult to attain and maintain, there has been escalating interest in bariatric surgery, including Roux-en-Y gastric…
- Trial name
- NCT01330914
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Bariatric Surgery Candidate, Bile Acid, Elevated Serum
Metabolic Effects of Endogenous Bile Acids After Gastric Bypass Surgery
Non-randomized, open-label, parallel-group clinical study evaluating the effects of endogenous bile acids on changes in plasma fibroblast growth factor-19 (FGF-19) and glucose metabolism by extended depletion of circulating bile…
- Conditions
- Bariatric Surgery Candidate, Bile Acid, Elevated Serum, Glucose Metabolism Disorders
- Trial name
- Bile-bar (NCT06925997)
- Testing
- Colesevelam
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Pain, Postoperative
TAP Blockade for Pain Control in One-Anastomosis Gastric Bypass
Patients will be randomized into 2 groups: TAP: Patients undergoing TAP blockade, associated with intravenous Acetaminophen analgesia IV: Patients receiving only intravenous Acetaminophen analgesia Postoperative pain 24 hours…
- Trial name
- NCT03775018
- Testing
- Transversus abdominis plane blockade, Intravenous analgesia
- Volunteers
- 140 people
- Sponsor
- Hospital General Universitario Elche
Obese Patients
External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery
Adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption (ANI guided rescue) compared to placebo, without increasing…
- Trial name
- NCT07809425
- Testing
- Investigatore hypothesize that adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption., Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate).
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University