Clinical trials: Gastric Bypass
Bariatric Surgery
Novel Technique in Closure of Mesenteric Defects After Laparoscopic Roux-en-Y Gastric Bypass and Its Effect on Internal Hernia: a Case-control Study
This study is to investigate the rate of internal hernia after laparoscopic Rox-en-Y gastric bypass when the defects are closed using cyano-acrylate glue.
- Trial name
- NCT04788199
- Testing
- Closure of mesenteric defects using glue
- Where
- United Kingdom
- Volunteers
- 928 people
- Sponsor
- Mansoura University
Obesity, Bariatric Surgery
Effects of Bariatric Surgery on Insulin
This study, conducted at the NIH Clinical Research Unit (CRU) at the Phoenix Indian Medical Center, will compare the effects of two methods of bariatric surgery, the adjustable BAND and Roux-en-Y gastric bypass, on insulin.
- Conditions
- Obesity, Bariatric Surgery, Gastric Bypass, Weight Loss
- Trial name
- NCT00535600
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Severe Obesity, Bariatric Surgery
Study on Impact of Lifestyle Change and Weight Loss Before Bariatric Surgery
The purpose of the trial is to determine whether a preoperative lifestyle intervention (targeting diet, exercise, and preparation for surgery) will favorably impact obesity-related parameters prior to bariatric surgery and…
- Trial name
- PREP (NCT00623792)
- Testing
- Preoperative lifestyle Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duquesne University
Bariatric Surgery
The Metabolic Effects of Prebiotic Supplementation After Roux-en-Y Gastric Bypass Surgery
In this study, it is aimed to evaluate whether the addition of prebiotics to patients' post-operative diets increases Roux-en-Y Gastric Bypass surgery effects.
- Trial name
- NCT03517345
- Testing
- Prebiotic, Control
- Volunteers
- 32 people
- Sponsor
- Istanbul University
Roux-en-y Anastomosis Site, Obesity, Morbid
Robotic Versus Laparoscopic Roux En-y Gastric Bypass
This study retrospectively identified 33 consecutive obese patients who underwent either laparoscopic or robotic gastric bypass procedures over a 2-year period.
- Conditions
- Roux-en-y Anastomosis Site, Obesity, Morbid, Bypass Complication, Anastomosis; Complications
- Trial name
- NCT05746936
- Testing
- Roux en-Y gastric bypass
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- University of Foggia
Bariatric Surgery, Roux-en Y Gastric Bypass
Gastro-Intestinal Digestion and Physiology After Bariatric Surgery
The goal of this clinical trial is to characterize gastrointestinal digestion and physiology in patients after bariatric surgery, or people living with obesity.
- Conditions
- Bariatric Surgery, Roux-en Y Gastric Bypass, Sleeve Gastrectomy, Obesity & Overweight
- Trial name
- GIBa (NCT07286968)
- Testing
- Gastro-intestinal aspiration, Telemetric
- Where
- Netherlands
- Volunteers
- 51 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bariatric Surgery, Obesity
Ovarian Reserve and Bariatric Surgery
The expansion of the obesity epidemic is accompanied with an increase in bariatric procedures, in particular in women of reproductive age.
- Conditions
- Bariatric Surgery, Obesity, Reproductive Health, Fertility
- Trial name
- BARIAOVO (NCT04583150)
- Testing
- Bariatric surgery
- Where
- 14 sites in France
- Volunteers
- 238 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Morbid
BASUN - Risks for Malnutrition, Metabolic Bone Disease and Impaired Oral Health After Obesity Treatment
Weight-reducing obesity surgery (OS) generally gives good results but complications are common; e.g. impaired weight loss, weight regain, bowel pain, diarrhea, vitamin/mineral deficiency, osteoporosis and impaired dental health.
- Trial name
- BASUN (NCT03152617)
- Where
- Sweden
- Volunteers
- 1,400 people
- Sponsor
- Göteborg University
Obese Patients, Bariatric Surgical Pain
Non-opioid Anesthesia Based on Thoracic Paravertebral Block During Laparoscopic Sleeve Gastrectomy
Regional anesthesia is a technique in which a local anesthetic is injected near a nerve or spinal cord to block sensation, motor stimulation, and pain.
- Conditions
- Obese Patients, Bariatric Surgical Pain, Bariatric Surgery (Sleeve Gastrectomy ), Non-Opioid Pain Management
- Trial name
- NCT07084753
- Testing
- Levobupivacaine, Dexamethasone contained in the solution for thoracic paravertebral block, Adrenaline
- Where
- Croatia
- Volunteers
- 36 people
- Sponsor
- IVO JURISIC
Obesity, Morbid
Effect of Biliopancreatic Diversion on Glucose Homeostasis
Biliopancreatic diversion (BPD) surgery results in greater resolution of type 2 diabetes than all other bariatric surgical procedures, and it is hypothesized that this procedure has specific beneficial effects on glucose…
- Trial name
- BPD-Mingrone (NCT03111953)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Biliopancreatic Diversion Surgery
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Endotracheal Intubation, Rapid Airway Management Positioner
Evaluation of the Rapid Airway Management Positioner
The purpose of this study is to determine if the Rapid Airway Management Positioner (RAMP, AirPal, Center Valley, PA) is a useful positioning device for direct laryngoscopy and tracheal intubation in obese patients undergoing…
- Trial name
- RAMP (NCT00581230)
- Testing
- Laryngoscopy with RAMP, Laryngoscopy without RAMP
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
Fructose-induced Intestinal de Novo Lipogenesis
8 healthy volunteers, 8 pre-bypass obese subjects, 8 subjects between 12-18 months post-bypass, and 8 subjects matched to the post-bypass patients will be studied in two sub-studies Sub-study 1) after ingestion of two or three…
- Trial name
- FIDNL (NCT01792089)
- Testing
- fat+protein meal, Fat + protein + 13C fructose meal, Fat+protein+13C fructose+glucose meal
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Laparoscopic Gastric Bypass Surgery, Ketamine
Perioperative Ketamine for Pain With Gastric Bypass
Opioid medications such as morphine, hydrocodone and oxycodone are standard for treating pain after surgery, however there are disadvantages.
- Trial name
- NCT03448068
- Testing
- Ketamine, Standard therapy
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Postprandial Hypoglycemia, End-stage Renal Disease (ESRD)
Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease
Post-meal low blood sugar (postprandial hypoglycemia) is a common problem after certain stomach surgeries like gastric bypass or stomach removal.
- Conditions
- Postprandial Hypoglycemia, End-stage Renal Disease (ESRD), Gastrectomy, Glucose Metabolism Disorders
- Trial name
- AnPHy-ReD (NCT07580079)
- Testing
- Anakinra (interleukin-1 receptor antagonist)
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Marc Donath
Obesity and Obesity-related Medical Conditions
Bariatric Surgery vs. Semaglutide vs. Tirzepatide
The recent introduction of the new generation of anti-obesity medications (AOMs) will change the future of obesity treatment. These highly effective medications, such as high-dose semaglutide and tirzepatide, are hormone…
- Trial name
- NCT06803888
- Testing
- Bariatric Surgery, Semaglutide, Tirzepatide
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Ali Aminian
Diabetes Mellitus Type 2 in Obese
DMBSS-A Randomized Trial of Different Laparoscopic Gastric Bypass Surgery in Patients With Obesity-related T2DM
The investigators would like to conduct a randomized clinical trial to compare the efficacy of diabetes treatment between different gastric bypass procedures involving type 2 diabetics patients with BMI from 27.5 to 35 kg/m2
- Trial name
- DMBSS (NCT01989988)
- Testing
- LMGB, LRYGB, SADJB
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Min-Sheng General Hospital
Bariatric Surgery Candidate, Pain, Postoperative
The Effect of Liposomal Bupivacaine on Post Operative Pain and Narcotic Use After Bariatric Surgery
This study is prospective, randomized trial in which the efficacy of liposomal bupivacaine (Exparel®) is compared to standard bupivacaine local surgical site injection in reducing total IV and oral morphine equivalents required…
- Trial name
- Exparel (NCT03196505)
- Testing
- Exparel 266 MG Per 20 ML Injection, Bupivacaine
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity
Clinic-based Nasopharyngoesophagogastroscopy Following Bariatric Surgery
This study aims to determine that this new technology, nasopharyngoendoscopy, is just as effective in diagnosing problems as the current gold standard.
- Trial name
- EGScan (NCT01602991)
- Testing
- clinic-based nasopharyngoendoscopy, Standard Endoscopy
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dennis Hong MD
Type 2 Diabetes
Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID)
This research study will investigate the safety and effectiveness of weight loss surgery for overweight persons with type 2 diabetes.
- Trial name
- SOLID (NCT01040468)
- Testing
- Roux-en-Y Gastric Bypass surgery, Laparoscopic Adjustable Gastric Banding surgery, Intensive Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Obesity
Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures
This is a cross-sectional study enrolling 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB) 11 age- and weight-matched female subjects 10 normal weight (Body Mass Index 19-25 kg/m2)…
- Trial name
- NCT02160379
- Testing
- standard test meal
- Where
- Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Lausanne