Clinical trials: Gastric Varices
Cirrhoses, Liver
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis.
- Trial name
- NCT07267260
- Testing
- Vonoprazan 20 mg
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- King Edward Medical University
Fundal Gastric Varices, Endoscopic Ultrasound (EUS)-Guided Coil Deployment
Clip and Coil in Fundal Gastric Varices With a Large Shunt
Endoscopic ultrasound (EUS)-guided coil deployment is a promising technique for the endoscopic management of gastric varices. However, coil migration may occur in patients with large drainage collaterals.
- Conditions
- Fundal Gastric Varices, Endoscopic Ultrasound (EUS)-Guided Coil Deployment, Titanium Clips, Ectopic Embolization
- Trial name
- NCT07263503
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Portal Hypertension Related to Cirrhosis, Esophageal Varices
2D-shear Wave Spleen Elastography in Clinically Significant Portal Hypertension and High-risk Varices
The primary objective of this study is to evaluate the role of spleen shear wave elastography (SWE-SSM) for ruling in and ruling out clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic…
- Trial name
- NCT07122622
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
TIPS, Portal Hypertension
TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease
Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal…
- Conditions
- TIPS, Portal Hypertension, Porto-Sinusoidal Vascular Disease, Refractory Ascite
- Trial name
- TIPS-PSVD (NCT07163689)
- Where
- France
- Volunteers
- 360 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Portal Hypertension, Cirrhosis
Safety of Discontinuing NSBBs in Cirrhotic Patients With Managed Primary Aetiological Factors
This multicentre, prospective cohort study aims to enrol 375 patients with cirrhosis who meet the following criteria: 1. effective management or elimination of the primary aetiological factor (i.e., sustained virological response…
- Conditions
- Portal Hypertension, Cirrhosis, Varices, Esophageal
- Trial name
- NCT06549673
- Where
- 8 sites in Australia, China and 3 more
- Volunteers
- 375 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Varices, Liver Cirrhosis
A Digital Tongue Diagnosis Model for High- and Low-risk Esophagogastroduodenal Varices in Cirrhosis
The aim of this observational study is to establish an AI deep learning model that can dianosie high-risk varices for patients with cirrhosis effeciently.
- Conditions
- Esophageal Varices, Liver Cirrhosis, Sublingual Varices, Portal Hypertension
- Trial name
- NCT05979935
- Testing
- tongue diagnosis
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Qilu Hospital of Shandong University
Hepatocellular Carcinoma, Esophageal Varix
Prophylactic Endoscopic Variceal Ligation in Patients With High-risk Esophageal Varices Receiving Atezo/Bev for HCC
The goal of this study is to evaluate whether prophylactic endoscopic variceal ligation (EVL) can prevent esophageal variceal bleeding in patients with hepatocellular carcinoma (HCC) receiving atezolizumab and bevacizumab…
- Conditions
- Hepatocellular Carcinoma, Esophageal Varix, Bleeding Esophageal Varices
- Trial name
- ESCOAT (NCT06819566)
- Testing
- Endoscopic variceal ligation (EVL)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Asan Medical Center
Gastric Varices Bleeding
Efficacy and Safety of Contrast EUS-Guided Tissue Glue/Coil Devascularization vs. BRTO for Preventing Recurrent Gastric Variceal Bleeding
The goal of this clinical trial is to compare the effectiveness of EUS-guided tissue glue/coil injection and BRTO in preventing rebleeding of gastric varices (GVs) in patients with portal hypertension and GVs (including those…
- Trial name
- NCT07049146
- Testing
- EUS-guided tissue glue/coil injection, BRTO
- Where
- China
- Volunteers
- 242 people
- Sponsor
- West China Hospital
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal and/or Gastric Varices, Hepatocellular Carcinoma (HCC)
Esophageal Varices Prophylaxis in Hepatocellular Carcinoma Treated With Atezolizumab and Bevacizumab
The goal of this prospective cohort study is to evaluate the progression of esophagogastric varices in patients treated with atezolizumab-bevacizumab.
- Trial name
- NCT06961526
- Testing
- Esophageal band ligation
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Tanta University
Esophageal Varices
Fecal Calprotectin for Prediction of Esophageal Varices in Cirrhotic Patients
The goal of this cross-sectional observational study is to evaluate the accuracy of fecal calprotectin versus non-invasive scores in assessing the presence and grading of esophageal varices in Egyptian patients.
- Trial name
- NCT06908798
- Testing
- fecal calprotectin
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Tanta University
Esophageal Varices
Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices
The goal of this randomized controlled trial is to evaluate the cross-section band ligation technique versus the stepladder band ligation technique in esophageal varices prophylaxis.
- Trial name
- NCT06881082
- Testing
- endoscopic band ligation with cross-section technique, Endoscopic band ligation using stepladder technique
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Tanta University
Esophageal and Gastric Varices
Evaluation of Endoscopic Treatment Effect Based on HVPG
This study aims to evaluate the endoscopic treatment effect and related influencing factors of patients with esophageal and gastric varices based on HVPG.
- Trial name
- NCT06863519
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Variceal Bleeding
Efficacy and Safety of Intravenous Vitamin K1 in Management of Acute Variceal Bleeding
The administration of Vitamin K1 (Vit-K1) injection is frequently utilized in clinical practice for managing upper gastrointestinal bleeding (UGIB) associated with liver cirrhosis, despite insufficient evidence supporting its…
- Trial name
- NCT06839352
- Testing
- Vitamin K1
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Viral Hepatitis B, Viral Hepatitis D
Replicor Compassionate Access Program
The goal of this compassionate access program is to provide early access to REP 2139-Mg for patients with HBV mono-infection or HBV / HDV co-infection who either have advanced (decompensated) cirrhosis or who have failed to…
- Conditions
- Viral Hepatitis B, Viral Hepatitis D, Cirrhosis, Liver, Decompensated Cirrhosis
- Trial name
- RCAP (NCT05683548)
- Testing
- REP 2139-Mg, Tenofovir Disoproxil Fumarate, Pegylated interferon alpha2a
- Where
- 13 sites in Austria, France and 3 more
- Sponsor
- Replicor Inc.
Hepatocellular Carcinoma (HCC), Esophageal Varices
Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC
The goal of this clinical trial is to evaluate whether endoscopic variceal ligation (EVL) or carvedilol is more effective at preventing the first esophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
- Trial name
- P-HCC-CVL (NCT06594744)
- Testing
- Endoscopic variceal ligation, Carvedilol
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hepatocellular Carcinoma, Liver Cirrhosis
Liver and Spleen Stiffness to Predict the Presence of Esaphageal Varices in Cirrhotic With Advanced HCC
Elasto-HCC is a prospective, uncontrolled, multicenter observational study involving several hepatology centers in Italy. Patients with liver cirrhosis and advanced hepatocellular carcinoma (HCC) who will need to undergo systemic…
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Portal Hypertension
- Trial name
- ELASTO-HCC (NCT06773260)
- Testing
- Liver and Spleen stiffness measurement.
- Where
- 12 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliero Universitaria Policlinico Modena
Bleeding Gastric Varices, Cirrhosis
"Early TIPS" Versus Glue Obliteration to Prevent Rebleeding From Gastric Varices
The primary objective of the study is to demonstrate the superiority of an "early tips" strategy over standard treatment by glue obliteration (G0) in preventing bleeding recurrence or death at one year after a non GOV1 gastric…
- Trial name
- GAVAPROSEC (NCT03705078)
- Testing
- Transjugular Portosytemic Shunt (TIPS), glue obliteration
- Where
- 20 sites in France
- Volunteers
- 104 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon