Clinical trials: Gastric Varices
Variceal Bleeding, Cirrhosis
Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding
This study is performed to compare the efficacy of terlipressin, somatostatin, and octreotide in patients with variceal bleeding for the control of variceal bleeding in combination with endoscopic therapy.
- Trial name
- NCT00966355
- Testing
- Terlipressin, Somatostatin, Octreotide
- Where
- South Korea
- Volunteers
- 1,034 people
- Sponsor
- Korea University
Esophagogastric Varices, Portal Hypertension
Treatment Outcomes for Portal Hypertension Esophageal and Gastric Varices
This study is a single-center, prospective cohort study based on real-world data. Patients with portal hypertension and esophagogastric varices were enrolled and divided into an endoscopic treatment group and a non-endoscopic…
- Trial name
- NCT07358663
- Where
- China
- Volunteers
- 1,384 people
- Sponsor
- Shanghai Zhongshan Hospital
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust
Esophageal Varices, Portal Hypertension
Improve the Strategies of Endoscopic and Interventional Treatment of Gastroesophageal Hemorrhage in Portal Hypertension
Endoscopic esophageal variceal ligation combined with gastric variceal embolization using tissue glue is currently the first-choice method for preventing rebleeding in patients with cirrhosis and portal hypertension.
- Trial name
- NCT06970509
- Where
- 10 sites in China
- Volunteers
- 1,450 people
- Sponsor
- Shanghai Zhongshan Hospital
Gastric Varices
Primary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal bleeding.
- Trial name
- NCT02468180
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Cirrhoses, Liver
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis.
- Trial name
- NCT07267260
- Testing
- Vonoprazan 20 mg
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- King Edward Medical University
Esophageal and Gastric Varices, Liver Cirrhosis
Decompression Intervention of Variceal Rebleeding Trial (DIVERT)
The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the…
- Trial name
- NCT00006161
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS), Distal Splenorenal Shunt
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Esophageal Varices, Portal Hypertension
Non-invasive Predictors of Esophageal Varices and Their Correlation to Upper Endoscopic Findings
The goal of this observational study: To evaluate the diagnostic accuracy of non-invasive markers in predicting the presence and grading of esophageal varices in children with portal hypertension.
- Trial name
- NCT07464522
- Volunteers
- 51 people
- Sponsor
- Assiut University
Cirrhosis
Primary Prophylaxis of Gastric Varix Bleed
In patients who have never bled from gastric varix (GOV2 and IGV1), cyanoacrylate injection will be better than both beta-blocker therapy and no treatment in prevention of gastric variceal bleed.
- Trial name
- NCT00905996
- Testing
- Endoscopic cyanoacrylate injection, Beta-blocker (propranolol)
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Govind Ballabh Pant Hospital
Portal Hypertension
Standard Therapy and TIPS for Moderate to High-risk Esophageal and Gastric Variceal Bleeding
Comparison of endoscopic therapy combined with non-selective therapy β Receptor blockers (NSBBs) and TIPS in the treatment of liver cirrhosis The impact of reducing bleeding on the survival of critically ill patients.
- Trial name
- NCT06013670
- Testing
- Endoscopy+NSBBs, Transjugular intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
CIRRHOSIS, ESOPHAGEAL VARICES
PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES?
This prospective randomized controlled trial will compare endoscopic band ligation (EBL) with propranolol and EBL alone in primary prophylaxis of variceal bleeding among cirrhotic patients with high-risk varices.
- Trial name
- NCT01893541
- Testing
- ENDOSCOPIC BAND LIGATION, PROPRANOLOL, a multiband ligation device
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Esophageal Varices
Study of Capsule Endoscopy to Determine the Accuracy for Detection of Esophageal Varices
Esophageal capsule endoscopy is sedation-less alternative to upper endoscopy for evaluating esophageal lesions and potentially other upper gastrointestinal lesions.
- Trial name
- NCT01079416
- Testing
- Capsule endoscopy, Esophagogastroduodenoscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Esophageal and/or Gastric Varices, Hepatocellular Carcinoma (HCC)
Esophageal Varices Prophylaxis in Hepatocellular Carcinoma Treated With Atezolizumab and Bevacizumab
The goal of this prospective cohort study is to evaluate the progression of esophagogastric varices in patients treated with atezolizumab-bevacizumab.
- Trial name
- NCT06961526
- Testing
- Esophageal band ligation
- Where
- Egypt
- Volunteers
- 110 people
- Sponsor
- Tanta University
Esophageal Varices, Liver Cirrhoses
Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices
This study evaluates the safety and efficacy of 24-hour vs 72-hour octreotide infusion after variceal banding in cirrhotic patients with bleeding esophageal varices.
- Conditions
- Esophageal Varices, Liver Cirrhoses, Bleeding Esophageal Varices, Upper Gastrointestinal Bleeding
- Trial name
- LOVARB (NCT03624517)
- Testing
- Octreotide
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Medical University of South Carolina
Esophageal Varices
Cross-section Band Ligation Versus Stepladder Band Ligation of Esophageal Varices
The goal of this randomized controlled trial is to evaluate the cross-section band ligation technique versus the stepladder band ligation technique in esophageal varices prophylaxis.
- Trial name
- NCT06881082
- Testing
- endoscopic band ligation with cross-section technique, Endoscopic band ligation using stepladder technique
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Tanta University
Esophageal and Gastric Varices
Study on Portal Vein Pressure Gradient Measurement Under Endoscopic Ultrasound Guidance for Gastric Fundal Varices
This study aimed to evaluate the feasibility and safety of direct gastric variceal pressure measurement in patients with large spontaneous portosystemic shunts, and to determine whether the gastric variceal pressure gradient…
- Trial name
- NCT07478770
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cirrhosis, Esophageal Varices
Carvedilol Plus EVL or Not for the Primary Prevention of Esophageal Variceal Bleeding in Carvedilol Non-responders
The goal of this clinical trial is to evaluate whether carvedilol plus endoscopic variceal ligation (EVL) is more effective for the primary prevention of esophageal variceal bleeding than carvedilol alone in carvedilol…
- Trial name
- CVL-NR (NCT06594783)
- Testing
- Carvedilol plus endoscopic variceal ligation, Carvedilol alone
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Esophageal Varices
Wired Magnetically Assisted Capsule Endoscopy and Esophageal Varices
The goal of this clinical trial is to compare the safeness and effectiveness of traditional esophagogastroduodenoscope (EGD) and wired magnetically assisted capsule endoscopy (MACE) in the diagnosis of esophageal varices in…
- Trial name
- NCT06017102
- Testing
- wired magnetic assisted capsule endoscopy, esophagogastroduodenoscopy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis
Study Evaluating the Efficacy and Safety of Belapectin for the Prevention of Esophageal Varices in NASH Cirrhosis
This seamless, adaptive, two-stage, Phase 2b/3, randomized, double-blind, multicenter, parallel-groups, placebo-controlled study will assess the efficacy, safety, and tolerability of belapectin compared with placebo in patients…
- Conditions
- Prevention of Esophageal Varices, NASH - Nonalcoholic Steatohepatitis, Cirrhosis
- Trial name
- NAVIGATE (NCT04365868)
- Testing
- belapectin
- Where
- 156 sites in United States, Argentina and 13 more
- Volunteers
- 357 people
- Sponsor
- Galectin Therapeutics Inc.
Gastric Varix
The Validation and Efficacy of Varix Trainer as a Training Device Esophagogastroduodenoscopy (a Multicenter Study)
The goal of this exploratory validation study is to compare levels of expertise (or non-expertise) between GI fellows and experts with the varix trainer.
- Trial name
- NCT05614999
- Testing
- Endoscopy training curriculum
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mahidol University