Clinical trials: Gastro-Intestinal Disorder
Colonic Neoplasms, Colonic Adenoma
Hot EMR vs Underwater Cold EMR for Large Colonic Adenomas
This randomized, multi-center trial aims to evaluate the advantages of underwater cold endoscopic mucosal resection technique (CS-EMR) in comparison to the conventional endoscopic mucosal resection technique (EMR) for laterally…
- Conditions
- Colonic Neoplasms, Colonic Adenoma, Colonic Lesion
- Trial name
- COWL (NCT06217250)
- Testing
- Traditional EMR, the cold snare ("CO"), underwater technique ("W"), and the use of submucosal lift ("L") in both study arms
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Dysphagia, Esophageal
Striated Esophageal Motor Function Modulation in Health and Disease
The investigators hypothesize that striated esophagus deglutitive motor function is modulated by pharyngeal phase swallowing biomechanics.
- Trial name
- NCT05708885
- Testing
- Concurrent manometry/impedance and fluoroscopy with and without laryngeal restriction, Concurrent manometry/impedance and fluoroscopy before and after six weeks of using swallow muscle exercising device
- Where
- United States
- Volunteers
- 557 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Crohn Disease, Healthy
Reducing Fatigue With CoQ10 Supplementation in Patients With Crohn's Disease Study
This study includes an open label clinical trial comparing two doses of CoQ10 for 8 weeks to improve fatigue among patients with Crohn's disease and a prospective cohort study of healthy controls taking CoQ10 for 2 weeks.
- Trial name
- NCT06419335
- Testing
- CoQ10
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Colorectal Neoplasia, Colorectal Cancer
The Longterm Risk of Advanced Colorectal Neoplasia After Colonoscopy - A Population-based Cohort Study in Hong Kong
The primary objective of this study is to analyze the 15-year cumulative incidence of advanced colorectal neoplasia and CRC-related mortality after the index colonoscopy.
- Trial name
- ACNC (NCT04815525)
- Where
- Hong Kong
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Appendicitis, Surgery
Raja Isteri Pengiran Anak Saleha Appendicitis Treatment Without Operation
The RIPASA score is a Clinical Prediction Rule (CPR) for the diagnosis of acute appendicitis. Since its inception in 2009, the RIPASA score has been validated in various population in healthcare institutions around the world and…
- Trial name
- RIPASA-TWO (NCT03169114)
- Testing
- Amikacin Injection, Appendicectomy
- Where
- Brunei
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Raja Isteri Pengiran Anak Saleha Hospital
Metabolic Syndrome, Gastric Cancer
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome After Radical Gastrectomy
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with gastric cancer complicated with metabolic syndrome were…
- Trial name
- Metabolomics (NCT06707714)
- Testing
- hypertension, diabetes, fatty liver
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Colorectal Cancer (CRC), Advanced Adenomas (AA)
Collection of Samples USOPTIVAL Study
A prospective multi-center observational study. The study will enroll eligible subjects from the United States to optimize the biomarker panel and evaluate the performance of a cfDNA marker panel selected by the Sponsor for CRC…
- Trial name
- NCT04792684
- Testing
- Optimization of Plasma Circulating Free-DNA (cfDNA) Marker Panel
- Where
- 16 sites in United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Urinary Tract Infections, Infectious Diarrhea
Creation of an E-toileting Log Through Classification of the Physical Properties of Stool and Urine Using TrueLoo™
The purpose of this study is to assess the feasibility of TrueLoo™, an Internet-connected smart toilet seat, in accurately monitoring and logging bowel movements and urinations of residents in senior living facilities across…
- Conditions
- Urinary Tract Infections, Infectious Diarrhea, Clostridium Difficile Infection, Gastrointestinal Disease
- Trial name
- NCT05008640
- Testing
- TrueLoo™
- Where
- 6 sites in United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Toi Labs, Inc.
Colorectal Cancer
Colorectal Cancer Screening in Xinxiang City
The primary objective of this study is to evaluate the sensitivity of the fecal protein dual-index test reagent for the detection of colorectal cancer (CRC).
- Trial name
- NCT06785714
- Where
- China
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Breast Cancer, Prostate Cancer
Survivorship Care Plans in a Community Oncology Practice
This is a two part observational study evaluating the feasibility of implementing an EHR-based model within a community oncology practice.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT03028584
- Testing
- Survey
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Lung Transplant Recipients, Diverticulitis
Epidemiology of Diverticulitis in Lung Transplant Recipients
The purpose of this study is to assess incidence, treatment modalities and outcome of complicated and uncomplicated diverticulitis in highly immunosuppressed lung transplant recipients (LTRs) in order to establish improved…
- Trial name
- NCT02132078
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Advanced Rectal Cancers
Preoperative Chemo-radiation With IG-IMRT Dose Escalation for Locally Advanced Rectal Cancers
Hypothesis : Therapeutic intensification by increasing the dose delivered to the tumor by RCMI (conformational radiotherapy by intensity modulation) in order to reduce local relapse, often associated with poor prognosis Primary…
- Trial name
- RADICAL (NCT03200249)
- Testing
- Preoperative chemo-radiation with IG-IMRT dose escalation
- Where
- 2 sites in France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Irritable Bowel Syndrome
Fructo-oligosaccharides and Irritable Bowel Syndrome
Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria.
- Trial name
- NCT00806104
- Testing
- Fructo-oligosaccharides, Maltodextrins
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beghin-Meiji
Celiac Disease
Telomeres Parameters in Celiac Disease
Celiac disease is an autoimmune process that causes destructive changes in the epithel of the small bowel and it is also a pre-malignant state (e.g lymphoma).
- Trial name
- NCT02126033
- Testing
- take blood samples
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic
Predictive Model For Anastomotic Leakage After Colorectal Cancer Surgery
This pilot study aimed to develop a simplified early postoperative model for AL risk stratification using readily available clinical and laboratory variables.
- Conditions
- Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic, Surgery Complications
- Trial name
- Doesn't exist (NCT07709923)
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Esophageal Squamous Cell Carcinoma, Esophagectomy
Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years
To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophagectomy, Radiotherapy, Chemotherapy
- Trial name
- NCT05604950
- Testing
- Since the data were collected retrospectively, there were no interventions
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Yongtao Han
Perforated Appendicitis
Evaluation the Role of Laparoscopic Management of Perforated Appendicitis
A laparoscopic appendectomy (LA) was first reported by Semm in 1983. Since then, its advantages, such as the aesthetic appearance of the wound, less postoperative pain, and faster recovery which facilitates early discharge, have…
- Trial name
- NCT03267082
- Testing
- Laparoscopic management of perforated appendicitis
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ulcerative Colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut.
- Trial name
- NCT05180279
- Testing
- 7-day sleep lab
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
IBS - Irritable Bowel Syndrome
Efficacy and Safety of a Probiotic Formulation in Adults With Irritable Bowel Syndrome With Diarrhea (IBS-D)
The purpose of the study is to monitor safety and to evaluate the efficacy of a probiotic formulation on abdominal pain, abnormal defecation, comorbid mood disorders (anxiety and depression) as well as general quality of life in…
- Trial name
- NCT05509725
- Testing
- Probiotic formulation
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Lallemand Health Solutions
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