Clinical trials: Gastro-Intestinal Disorders
Obesity
Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures
This is a cross-sectional study enrolling 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB) 11 age- and weight-matched female subjects 10 normal weight (Body Mass Index 19-25 kg/m2)…
- Trial name
- NCT02160379
- Testing
- standard test meal
- Where
- Switzerland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
HER2-positive Breast Cancer, HER2 Low
ISPY-P1.01:Evaluating the Safety of Weekly Paclitaxel With Trastuzumab Duocarmazine (SYD985) in Patients With Metastatic Cancer
This is an open-label, single-arm, multi-site phase I/Ib trial with SYD985, an antibody-drug conjugate (ADC) targeting HER2 on the cell membrane, combined with paclitaxel.
- Conditions
- HER2-positive Breast Cancer, HER2 Low, SYD-985, SYD985
- Trial name
- NCT04602117
- Testing
- Vic-trastuzumab duocarmazine (SYD985) + paclitaxel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QuantumLeap Healthcare Collaborative
Dysphagia
Clinical Trial for Clinical Excellence and Safety Evaluation of 4-channel Functional Electric Stimulator
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT05483582
- Testing
- 4-channel Electrical Stimulation Device, 2-channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
GERD (Gastroesophageal Reflux Disease)
Normal Values of Ambulatory 24-hour Oesophageal pH-impedance Monitoring in an Indian Cohort of Participants
This study aims to determine normal 24-hour pH-impedance monitoring values, including acid exposure time (AET), in healthy Indian adults. It will help improve GERD diagnosis in India by providing population-specific data.
- Trial name
- NCT06928350
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Solid Tumor Malignancies, Hematologic Cancer
The Application of 18F-G1 PET/CT Targeting Granzyme B in the Pan-cancer Immunotherapy
The purpose of this study is to explore the effectiveness of 18F-G1 PET/CT in patients with solid tumors and hematological malignancies receiving immunotherapy
- Conditions
- Solid Tumor Malignancies, Hematologic Cancer, Lung Cancer, Esophagus Cancer
- Trial name
- NCT07039474
- Testing
- 18F-G1
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Post Operative Pain, Appendicitis
Evaluation of Local Anesthetic at Incision Site
Patient will have usual appendectomy surgery with an injection of local or saline at incision site either before or after the incision at random.
- Trial name
- NCT02483689
- Testing
- Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Non-erosive Reflux Disease, Gastroesophageal Reflux
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings.
- Trial name
- CENERDD (NCT02788591)
- Testing
- Proton Pump Inhibitor (PPI) Therapy, Sucralfate
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- LCMC Health
Cardiometabolic Health, Gastro-intestinal Wellbeing
Effects of Wholegrains on Children's Health (KORN)
KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.
- Conditions
- Cardiometabolic Health, Gastro-intestinal Wellbeing, Cognitive Function, Overweight
- Trial name
- NCT04430465
- Testing
- Grain products high in wholegrains from oat and rye, Grain products low in wholegrains
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Parkinson Disease
The Dutch Parkinson and Cognition Study
Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms.
- Trial name
- DUPARC (NCT04180865)
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Small Intestine Length Measurement
Digital 3D Reconstruction Predicts Small Bowel Length
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing annually worldwide, and the prevalence of diabetes has reached 11.6% in China.
- Trial name
- DTDRPSBL-BS (NCT05338567)
- Testing
- Small intestine length measurement method
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Inflammatory Bowel Diseases, Depressive Episode
Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health
This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the impacts on quality-of-life outcomes and use of healthcare services in people aged 5 - 25 years…
- Conditions
- Inflammatory Bowel Diseases, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorder
- Trial name
- NCT05206734
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 19,469 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Pelvic Radiation Therapy, Radiation-induced Hemorrhagic Cystitis
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy
Patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues The number of cancer patients is expected to increase from 14.1 million around the world in 2012 to 19.3…
- Trial name
- PRISME (NCT02814864)
- Testing
- Mesenchymal Stromal Cell (MSC) injections
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dysphagia, Oropharyngeal
Reference Values for Videofluoroscopic Measures of Swallowing
Dysphagia (swallowing impairment) is a serious health condition seen in many age-related disease and injury processes. Although videofluoroscopy (VF) is an international "gold standard" dysphagia diagnostic exam, there is a…
- Trial name
- NIA_RV (NCT05497219)
- Testing
- Videofluoroscopic Swallowing Study (VF)
- Where
- 5 sites in United States, Canada
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes
The Impact of Glucotoxicity on Gastric Emptying in Chinese Patients With Newly Diagnosed Type 2 Diabetes
Gastric emptying is now recognized as a major determinant of the blood glucose response to carbohydrate in both health and type 2 diabetes (T2D).
- Trial name
- NCT05284344
- Testing
- Anti-Diabetics
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Liver Metastases
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer
This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or…
- Trial name
- HITM-SURE (NCT02850536)
- Testing
- anti-CEA CAR-T cells
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Roger Williams Medical Center
Gastroesophageal Reflux, Laryngopharyngeal Reflux
Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease
This study plans to learn more about reflux associated laryngeal symptoms, and more efficient ways to diagnose and treat this condition.
- Trial name
- NCT03619811
- Testing
- Reflux Band® Upper Esophageal Sphincter (UES) Assist Device
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
GERD
A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects
A Study to compare pharmacokinetics, pharmacodynamics and safety of UI058 and UIC202004 in healthy subjects
- Trial name
- NCT05282914
- Testing
- administration of UI058, administration of UIC202004
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
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