Clinical trials: Gastro-Intestinal Disorders
Mild to Moderate Depression
EMI Therapy for Depression in Hong Kong
To determine if a two-week ecological momentary intervention (two EMA + one EMI daily) as augmentation to treatment as usual would reduce depressive symptoms, rumination levels, and functioning in subjects with mild to moderate…
- Trial name
- NCT06430476
- Testing
- EMI, EMA
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Microbiota
Gut Microbiota in Chronic GI Diseases
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease.
- Trial name
- ChronicGI (NCT06532110)
- Testing
- Endoscopy/Colonoscopy
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- McMaster University
Anorectal Disorders
Anal Resting Pressure After Bidet, Compared to Sitz Bath
Sitz bath is conventional and empirical remedy and commonly recommended for non-operative treatment of various anal diseases. However, as there was no substitute for sitz bath until now, the patients have to accept the…
- Trial name
- Bidet(2) (NCT02244840)
- Testing
- Electronic bidet, Sitz bath
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colorectal Cancer, Colorectal Adenoma
Volatile Markers in Digestive Cancer
The study is aimed to determine the potential of volatile marker testing for identification of gastrointestinal cancers (in particular - colorectal and gastric cancers), the related precancerous lesions in the stomach and colon.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Gastric Cancer, Peptic Ulcer Disease
- Trial name
- VOLGACORE (NCT02332213)
- Testing
- Breath sampling for volatile marker detection, Upper endoscopy with biopsies, Colonoscopy with biopsies or lesion removal when required
- Where
- 2 sites in Latvia, Lithuania
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Breast Cancer, Colon Cancer
EXoPERT EMERALD Clinical Study
The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT07186296
- Testing
- EXoPred
- Where
- 9 sites in United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- EXoPERT
Obesity and Obesity-related Medical Conditions
Management of Obese Patients With Gastroesophageal Reflux Disease .
The aim of this study is to evaluate the efficacy Sleeve gastrectomy with cruroplasty with or without ligamentum teres wrapping for management of morbidly obese patients with concomitant reflux symptoms.
- Trial name
- NCT06599489
- Testing
- surgery ..operation
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hossam Mahmoud Ibrahim
Dysphagia
Mechanisms of Air-pulse Pharyngeal Sensory Stimulation Regulation Post-stroke Swallowing Neural Network Remodeling Via TRPV4 Channel
This randomized, double-blind, sham-controlled clinical trial will investigate the effects and potential neural mechanisms of pharyngeal air-pulse sensory stimulation in patients with post-stroke dysphagia.
- Trial name
- NCT07782424
- Testing
- Air-Pulse Sensory Stimulation
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Foshan
Caregiver Awareness About Dysphagia
Determining Dysphagia Awareness in Caregivers
Genetic, neuromuscular, gastrointestinal, cardiorespiratory diseases and congenital abnormalities can cause dysphagia in children (1, 2).
- Trial name
- NCT05186961
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Atılım University
Oropharyngeal Dysphagia
Effect of Pharyngeal Inhibition by rTMS on Swallowing Function
The aim of this study is to test the hypothesis that rTMS on the dominant swallowing hemisphere is able to modify swallowing coordination.
- Trial name
- rTMSvideoSS (NCT02170454)
- Testing
- magnetic stimulation
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Eosinophilic Esophagitis, Dysphagia
Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone
This study will compare response to treatment of Eosinophilic Esophagitis with montelukast vs standard therapy fluticasone. Investigators hypothesize that montelukast is equally effective in treating symptoms and histology of EoE…
- Trial name
- NCT01702701
- Testing
- Montelukast, Fluticasone
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
HNPCC
Uncertain Genetic Test Results for Lynch Syndrome
Background: Individuals have varying tolerances for receiving ambiguous information. However, not much is known about how ambiguous genetic testing information is received.
- Trial name
- NCT01646112
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Incontinence Associated Dermatitis
Development of a Risk Assessment Tool for Incontinence-associated Dermatitis (IAD): a Cohort Study on the Predictive Performance of Risk Factors for IAD
Objective: The primary goal of this prospective cohort study is to collect data on specific factors, including age, sex, stool consistency, etc. and assess their association with the development of IAD.
- Trial name
- INCONTECT (NCT06978751)
- Where
- 7 sites in Belgium, Sweden
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Colorectal Cancer, Familial Adenomatous Polyposis
DNA Adductomics for Colorectal Cancer Investigation
This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls.
- Conditions
- Colorectal Cancer, Familial Adenomatous Polyposis, Hereditary Non-polyposis Colon Cancer, Lynch Syndrome
- Trial name
- adductomics (NCT04865601)
- Testing
- resectomy of the colon
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Metabolic Syndrome, Gastric Cancer
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome After Radical Gastrectomy
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with gastric cancer complicated with metabolic syndrome were…
- Trial name
- Metabolomics (NCT06707714)
- Testing
- hypertension, diabetes, fatty liver
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Rumination
Role of Vagal Tone in Rumination Syndrome
Rumination syndrome is a condition in which people repeatedly and unintentionally regurgitate undigested or partially digested food from the stomach, rechew it, and then either re-swallow it or spit it out.
- Trial name
- NCT03912636
- Testing
- Diaphragmatic breathing, Deep Slow Breathing, Normal breathing
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Colorectal Cancer, Pancreatic Adenocarcinoma
Circulating Tumor DNA Exposure in Peripheral Blood
This is a prospective, multi-center, blinded feasibility study. The objective of this study is to test the feasibility of the detection of tumor DNA of a variety of tumors in peripheral blood using a novel process for the…
- Conditions
- Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer, Hepatocellular Carcinoma
- Trial name
- NCT03517332
- Where
- 6 sites in United States, Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Quantgene Inc.
Diabetes Mellitus
Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults
The purpose of this study is to determine whether domperidone was sufficient to accelerate gastric emptying of a high-fat solid meal and reduce satiety responses in a healthy adult population.
- Trial name
- NCT01347814
- Testing
- Domperidone 10mg
- Where
- Ireland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Lung Neoplasms, Pancreatic Neoplasms
Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques
This is a combined prospective and retrospective observational study aiming to validate a highly sensitive and specific blood-based method for the early diagnosis and post-treatment monitoring of multiple cancers.
- Conditions
- Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT07035587
- Testing
- Serial Blood Sampling for Molecular Profiling, One-Time Blood Sampling for Molecular Profiling
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Dysphagia, Esophageal, Esophageal Cancer
Validation of Instruments Used for Assessment of Dysphagia in Patients With Esophageal Cancer
This study validates 3 well known dysphagia scores for dysphagia due to malignancies of the oesophagus and gastro-oesophageal junction and to the Swedish language.
- Trial name
- NCT03066167
- Testing
- Validation of different dysphagia scores
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Lynch Syndrome
Trial to Compare eConsent With Standard Consent Among Prospective Biobank Participants
The goal of this trial is to determine whether the Sage eConsent framework (presented using an electronic application) is non-inferior to traditional, paper-based, human-mediated consent-and therefore could be part of an…
- Trial name
- NCT04131062
- Testing
- Electronic Consent (iPad)
- Where
- United States
- Volunteers
- 703 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic