Clinical trials: Gastro-Intestinal Disorders
Barrett Esophagus, Esophageal Neoplasm
Novel Biomarkers in the Neoplastic Progression of Barrett's Esophagus
The purpose of this study is to determine if there are any early changes in DNA markers of blood and esophageal tissue in people with gastric reflux, Barrett's esophagus or esophageal cancer that can warn of a progression to…
- Conditions
- Barrett Esophagus, Esophageal Neoplasm, Gastroesophageal Reflux
- Trial name
- BE (NCT00431756)
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Eosinophilic Esophagitis
Cow's Milk Elimination for Treatment of Eosinophilic Esophagitis
The investigators seek to assess the efficacy of removing cow's milk from an EoE patient's diet. This will be determined by esophageal inflammation and clinical and histological response to the milk elimination treatment.
- Trial name
- NCT05083156
- Testing
- Diet Change
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Iron Deficiency Anemia, Iron Overload
Iron Supplementation and Side Effects
The objective of this study is to examine patient-reported gastrointestinal side effects, as well as iron status indicators, inflammatory markers and oxidative stress following administration of ferrous sulfate and iron-enriched…
- Trial name
- NCT04018300
- Testing
- Ferrous sulfate, Aspiron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Fibromyalgia, Irritable Bowel Syndrome
Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective Cohort Study
This cohort study implements patient reported outcome measures (PROMs) for patients with bodily stress syndrome in a clinic for functional disorders.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Somatic Symptom, Chronic Fatigue Syndrome
- Trial name
- SYMPA (NCT04667611)
- Testing
- Psychosocial interventions
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
GERD - PPI Responders, GERD - PPI Non-responders
Acid Pocket: Position and Aspiration
Gastroesophageal reflux disease (GERD) is a very common condition affecting up to 30% of adults. To date, therapy consists of powerful acid suppression with proton pump inhibitors (PPI).
- Conditions
- GERD - PPI Responders, GERD - PPI Non-responders, Barrett Esophagus, Healthy Volunteers
- Trial name
- NCT02199002
- Testing
- multi-pH-impedance manometry catheter
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Travelers' Diarrhea, Functional Bowel Disorders
Trial Evaluating Chemoprophylaxis Against Travelers' Diarrhea - Prevent TD
The purpose of this study is to develop evidence on the relative efficacy of 2 rifaximin chemoprophylaxis regimens for the prevention of Travelers' Diarrhea (TD) in a deployed setting.
- Conditions
- Travelers' Diarrhea, Functional Bowel Disorders, Reactive Arthritis
- Trial name
- NCT02498301
- Testing
- Rifaximin
- Where
- 6 sites in United States, Kenya
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Waist, Hypertriglyceridemic
Dietary Incorporation of Lentils to Improve Metabolic Health
Approximately 40% of Americans are pre-diabetic or diabetic, mostly in the form of type 2 diabetes (T2D), which is heavily influenced by diet.
- Trial name
- NCT04448067
- Testing
- Dietary Lentil Intake, No Dietary Lentil CONTROL
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Montana State University
All Diagnosed Health Conditions, ADD/ADHD
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research.
- Conditions
- All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis
- Trial name
- NCT01931644
- Where
- United States
- Volunteers
- 17,667 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Dysbiosis
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
This prospective, observational pilot study is designed to assess feasibility, refine the target population, and quickly test qualitative and quantitative changes in the microbiome after short-term travel to South or Southeast…
- Trial name
- ABROAD (NCT03043300)
- Testing
- Screening Criteria Review, Pre-Travel Questionnaire, Pre-Travel Stool Specimen Collection
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emory University
Heartburn
A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes
This decentralized, randomized, double-blind, placebo-controlled, two-period crossover study will evaluate whether PepZinGI® (zinc-L-carnosine) reduces food-triggered heartburn compared with placebo.
- Trial name
- NCT07379645
- Testing
- PepZinGI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NutriScience Innovations, LLC
Diverticulitis
Diverticulitis: Antibiotics or Close Observation?
Rationale The prevalence of colonic diverticular disease is increasing in Western countries. Approximately 10 to 25% of patients with diverticular disease will eventually develop an episode of acute diverticulitis.
- Trial name
- DIABOLO (NCT01111253)
- Testing
- Amoxicillin-clavulanate
- Where
- 24 sites in Netherlands
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetic Foot Ulcer, Temporomandibular Disorder
Temporomandibular Dysfunction in Patients With Diabetic Foot Ulcers
The aim of this observational study is to investigate the effects of the type, area and duration of ulceration on jaw pain, mandibular function limitation, TMD and swallowing in individuals with diabetic foot ulcers.The main…
- Conditions
- Diabetic Foot Ulcer, Temporomandibular Disorder, Swallowing Disorder
- Trial name
- NCT06067022
- Testing
- observation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Harran University
Functional Gastrointestinal Disorders
Effects of Imagery Therapy vs Progressive Muscle Relaxation Therapy on Patients With Functional Abdominal Bloating
65% of the general population reported experiencing moderate to severe bloating symptoms. Bloating could be disturbing to patients and frustrating to the physicians as an effective treatment is still lacking.
- Trial name
- NCT04789967
- Testing
- Guided Imagery, Progressive Muscle Relaxation, Educational Audiobook
- Where
- Malaysia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Gastroesophageal Reflux, Respiratory Aspiration
Cromolyn Detection of Silent Aspiration
The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract.
- Conditions
- Gastroesophageal Reflux, Respiratory Aspiration, Idiopathic Pulmonary Fibrosis, Lung Transplantation
- Trial name
- NCT01841307
- Testing
- Cromolyn Sodium
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gestational Diabetes, Pregnancy Related
Gut and Oral Microbiome of GDM Patients During Pregnancy
The study aimed to clarify the characteristics of the intestinal and oral microbiome of Gestational Diabetes Mellitus(GDM) patients during the whole pregnancy, try to clarify the relationship between the microbiome and GDM.
- Trial name
- NCT04420507
- Where
- China
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Speech and Language Disorder, Speech Therapy
Providing Speech Therapy Awareness in Private Schools
There has been limited research in the area of speech and language therapy awareness in Pakistan. The study aims to assess the efficacy of providing speech therapy awareness in private schools through a pre-post model.
- Conditions
- Speech and Language Disorder, Speech Therapy, Speech Delay, Swallowing Disorder
- Trial name
- NCT04505696
- Testing
- Speech-Language Pathology Presentation
- Where
- Pakistan
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT01048840
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Regurgitation, Gastric, Diarrhea
To Assess the Safety and Tolerance of Infant Formula With Locust Bean Gum in Infants With Regurgitation
A randomized, controlled study to evaluate the safety and tolerance of an infant formula with locust bean gum in infants with regurgitation. (Solar)
- Trial name
- Solar (NCT04042454)
- Testing
- milk based anti-regurgitation infant formula, Milk based infant formula
- Where
- 16 sites in Italy, Poland and 1 more
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
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