Clinical trials: Gastro-Intestinal Disorders
Gastrointestinal Neoplasms, Bronchial Carcinoma
Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training
The purpose of the study is to tests the hypothesis, that N-acetylcysteine (a thiol-antioxidant)improves the exercise training effect on cancer patients that experience weight loss (cachexia) as assessed by muscle mass and…
- Conditions
- Gastrointestinal Neoplasms, Bronchial Carcinoma, Hodgkin Disease, Non-Hodgkin Lymphoma
- Trial name
- NCT00196885
- Testing
- N-acetylcysteine
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- German Cancer Research Center
Cancer, Breast Cancer
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
The objective of this protocol is to develop an institution-wide liquid biopsy protocol that will establish a common process for collecting blood and corresponding archived tumor specimens for future research studies at the…
- Conditions
- Cancer, Breast Cancer, Lung Cancer, Colon Cancer
- Trial name
- LIBERATE (NCT03702309)
- Where
- Canada
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Coronary Heart Disease, Stroke
Evaluating Tools for Health Promotion and Disease Prevention
The study will evaluate the effect of familial risk assessment and prevention prompts tailored to familial risk on health behaviors and use of preventive services among adults who are members of primary care practices in the U.S.
- Conditions
- Coronary Heart Disease, Stroke, Diabetes, Breast Cancer
- Trial name
- NCT00164658
- Testing
- Familial risk assessment and personalized prevention messages
- Where
- 3 sites in United States
- Volunteers
- 8,400 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Fecal Fat Increased, Obesity
Effect of Potato Fiber on Appetite and Fecal Fat Excretion
Results have indicated that some dietary fibers increase fecal fat excretion and particularly viscous fibers suppress appetite sensation and reduce energy intake. Both these effects may contribute to body weight management.
- Conditions
- Fecal Fat Increased, Obesity, Appetite
- Trial name
- POFIBA (NCT02957318)
- Testing
- FiberBind, RG-I fiber
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Esophagitis, Inflammation
Comparison of Acid Reflux at Two Levels in the Esophagus Using the BRAVO Capsule
The purpose of this research is to study the level of acid exposure above the gastroesophageal junction and the distal esophagus in patients with reflux symptoms using a capsule type acid measurement system.
- Conditions
- Esophagitis, Inflammation, Gastritis, Abdominal Pain
- Trial name
- NCT00579410
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Osteoporosis, Obesity
Impact of Milk and Yogurt Supplementation on Bone Health, Body Composition, and Gut Microbiota in Canadian Young Adults
Milk and dairy products contain significant amounts of nutrients that contribute to optimal health - nutrients like calcium, vitamin D, and high-quality protein.
- Trial name
- NCT06265246
- Testing
- Habitual Diet + Milk, Habitual Diet + Yogurt
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Hypercholesterolemia, Osteoporosis
Effect of β-cryptoxanthin (β-Cx), Plant Sterols and Galactooligosaccharides on Systemic and Gastrointestinal Markers
Regular consumption of a beverage containing β-cryptoxanthin (β-Cx) and plant sterols (PS) has been shown to exert a synergic effect in reducing some markers of cardiovascular risk and bone-remodeling (formation and resorption).
- Conditions
- Hypercholesterolemia, Osteoporosis, Postmenopausal Disorder
- Trial name
- NCT03469518
- Testing
- β-Cx plus PS plus GOS, β-Cx plus PS
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Puerta de Hierro University Hospital
Obesity, Gastro Esophageal Reflux Disease
Effect of Routine Anterior Crural Repair in De-Novo Gastroesophageal Reflux After Laparoscopic Sleeve Gastrectomy
The purpose of the study is to evaluate the superiority of anterior crural repair during sleeve gastrectomy over no repair in decreasing the incidence of gastroesophageal reflux disease.
- Trial name
- NCT04884074
- Testing
- Standard Sleeve Gastrectomy plus Anterior Crural Repair, Standard sleeve gastrectomy (SSG, the control group)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diarrheal Disease, Infectious, Gastrointestinal Disease
Phase 1 Trial for Safety, Tolerability, and Immunogenicity of a Live, Attenuated, Oral Shigella/ETEC Combination Vaccine to Healthy Adults
This is a Phase 1 dose escalating study to assess the safety, tolerability, and immunogenicity of ShigETEC, a live, attenuated Shigella/ETEC combination vaccine given orally to healthy European adults 18 to 45 years of age.
- Conditions
- Diarrheal Disease, Infectious, Gastrointestinal Disease, Reactive Arthritis
- Trial name
- NCT05409196
- Testing
- ShigETEC live, attenuated, oral vaccine
- Where
- Hungary
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Eveliqure Biotechnologies GmbH
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Chronic Obstructive Pulmonary Disease
Decreased Tongue Strength is Related to Skeletal Muscle Mass in COPD Subjects
Background: Dysphagia is frequently observed in subjects with chronic obstructive pulmonary disease (COPD). But tongue strength has not been investigated yet in COPD subjects.
- Trial name
- NCT04761380
- Testing
- balloon-based tongue pressure measurement device
- Where
- Japan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Kindai University
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Domestic Violence
Brief Yoga and Mindfulness for Women Who Have Experienced Domestic Violence
This study aimed to examine the effectiveness of a brief yoga- and mindfulness-based psychoeducation program and its working mechanisms in improving psychological health parameters (depression, anxiety, and stress) among women…
- Trial name
- NCT06061029
- Testing
- Brief Yoga- and Mindfulness-Based Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Pelvic Radiation Therapy, Radiation-induced Hemorrhagic Cystitis
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy
Patients receiving radiation therapy are still at risk for side effects due to off-target radiation damage of normal tissues The number of cancer patients is expected to increase from 14.1 million around the world in 2012 to 19.3…
- Trial name
- PRISME (NCT02814864)
- Testing
- Mesenchymal Stromal Cell (MSC) injections
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder, Gastrointestinal Symptoms
Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder
This protocol is a blinded randomized controlled study of the effects of BB-12 with LGG at different doses in 70 healthy children with autism spectrum disorders at lower and higher doses over an 56-day period and a 28- day…
- Trial name
- NCT03514784
- Testing
- BB-12 with LGG (Higher Dose), BB-12 with LGG (Lower Dose)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Anxiety, Gastric Carcinoma
Educational Brochure in Preparing Patients With Gastric Cancer and Their Caregivers for Recovery After Surgery
This pilot clinical trial studies an educational brochure in preparing patients with gastric cancer and their caregivers for recovery after surgery.
- Conditions
- Anxiety, Gastric Carcinoma, Stress
- Trial name
- NCT02334332
- Testing
- Educational Intervention, Standard Follow-Up Care, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Irritable Bowel Syndrome
Are Sleeping Disorders Associated With Visceral Hypersensitivity in Irritable Bowel Syndrome Patients ?
Visceral hypersensitivity is frequent in IBS population up to 60% and is correlated with severity and altered quality of life. Sleeping troubles are most frequent in IBS population.
- Trial name
- S3i (NCT04168047)
- Testing
- Barostat procedure, Anxiety and Depression Evaluation, Assessment of sleep quality
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Colorectal Disorders, Incisional Hernia
Incisional Hernia and Adhesion-Related Bowel Obstruction
Despite of technological advances in surgery, incisional hernia and bowel obstruction remain frequent surgical complications. To date, the relationship between these two types of surgery and the occurrence of incisional hernia…
- Conditions
- Colorectal Disorders, Incisional Hernia, Bowel Obstruction
- Trial name
- NCT02116881
- Testing
- Colorectal Surgery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
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