Clinical trials: Gastro-Intestinal Disorders
Gastric Cancer, Colorectal Cancer
Oral, Fecal and Intratumoral Microbiome Atlas in Colombian Patients With Advanced Solid Tumors Receiving First-Line Immunotherapy
This is a prospective observational cohort study conducted at Fundación CTIC in Bogotá, Colombia. It characterizes the oral, fecal and intratumoral microbiome of Colombian adults with advanced solid tumors (gastric, colorectal…
- Conditions
- Gastric Cancer, Colorectal Cancer, Breast Cancer, Cervical Cancer
- Trial name
- ATLAS (NCT07676461)
- Testing
- First-line immunotherapy (immune checkpoint inhibitors), INVIMA-approved, standard of care
- Where
- Colombia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Head and Neck Neoplasms, Swallowing Sparing IMRT
The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas
The aim of SWOAR TRIAL is to test sparing of Dysphagia/ Aspiration risk structures (DARS) and contra lateral submandibular gland by IMRT.
- Trial name
- SWOAR (NCT05187091)
- Testing
- Swallowing and submandibular sparing IMRT, Standard IMRT with medical CRT/RT, Cisplatine
- Where
- India
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences
Barrett Esophagus, Esophageal Adenocarcinoma
Barrett's Esophagus Patient Registry
The ultimate goal of the Barrett's Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett's esophagus and esophageal adenocarcinoma (EAC).
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Gastroesophageal Reflux
- Trial name
- BPR (NCT01776346)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy
Studies of the Early Meal Phase in Healthy Individuals - Nutrient Absorption and Gastrointestinal Hormone Secretion
To investigate gastrointestinal hormone secretions and nutrient absorption during the early meal phase we will recruit 12 healthy young men. They will be equipped with peripheral intravenous catheters for frequent blood sampling.
- Trial name
- NCT03543423
- Testing
- Oral glucose tolerance test, Liquid mixed meal test
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Iron Deficiency Anemia Treatment, Microbial Colonization
GI Effects of Iron in Healthy Volunteers
Over recent years there has been a lot of research looking at how the bacteria in our gut affects our health. Some medications are known to cause changes in gut bacteria.
- Conditions
- Iron Deficiency Anemia Treatment, Microbial Colonization, Iron-deficiency, Iron Deficiency Anemia
- Trial name
- NCT04705662
- Testing
- Lactulose breath test, Stool sample, Daily Diary
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dr Anthony Hobson
Overweight and Obesity, Type 2 Diabetes
Fat Metabolites and Gut Hormones
To investigate the effects of different fat metabolites on gut hormone secretion in gastric bypass operated subjects and BMI-matched controls.
- Conditions
- Overweight and Obesity, Type 2 Diabetes, Bariatric Surgery, Gut Hormones
- Trial name
- NCT03223389
- Testing
- C-8 dietary oil, Tricaprylin, Olive oil
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Stomach Ulcer, Duodenal Ulcer
MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001)
This study will determine how if MK0782 is safe and tolerable and to determine how often and the severity of stomach and small intestine ulcers develop following administration of MK0782 plus enteric coated aspirin, rofecoxib…
- Trial name
- NCT00543868
- Testing
- MK0782
- Volunteers
- 462 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Eosinophilic Esophagitis
Eosinophilic Oesophagitis Assessment With String Testing
Eosinophilic oesophagitis (EoE) is an inflammatory condition of the oesophagus (food pipe) that can lead to difficulty swallowing and to food to getting stuck and has become increasingly common over the past 40 years.
- Trial name
- EoEAST (NCT06159218)
- Testing
- CEST - coiled oesophageal string test
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Parkinson Disease, Irritable Bowel Syndrome
Early Signs of Parkinsons Disease in IBS
Bowel symptoms like constipation and abdominal pain are characteristic symptoms of irritable bowel syndrome (IBS). The pathogenesis and pathophysiology are not fully understood but subject to intense research, with emphasis on…
- Trial name
- NCT05573542
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Symptoms and Signs, Malignancy
Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy
Endoscopy is the best means of finding early stage of upper gastrointestinal diseases, especially early cancer and benign ulcers.
- Conditions
- Symptoms and Signs, Malignancy, Ulcer Peptic
- Trial name
- NCT03736824
- Testing
- endoscopy
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Achalasia
Achalasia: Mechanisms Underlying Treatment Failure
In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear.
- Trial name
- NCT02055469
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Gastrointestinal Disorder, Functional, Regurgitation, Gastric
Transition to Infant Formula Feeding on Gastrointestinal Regurgitation (TIGER) Study
To compare the frequency of regurgitation and other digestive outcomes between infants who receive an infant formula based on whole goat milk and an infant formula based on cow milk proteins during the transition period from…
- Conditions
- Gastrointestinal Disorder, Functional, Regurgitation, Gastric, Colic, Infantile, Constipation - Functional
- Trial name
- TIGER (NCT05363553)
- Testing
- Infant formula based on whole goat milk, infant formula based on cow milk proteins
- Where
- Thailand
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Dairy Goat Co-operative (N.Z.) Limited
Frailty, Surgery--Complications
Protocol for Patients Above 75 Years Undergoing Emergency Laparotomy
In the ProPEL study the effect of a protocol designed for elderly patients about to undergo emergency abdominal surgery will be investigated. The protocol addresses issues of both frailty and ceiling-of -care decisions.
- Conditions
- Frailty, Surgery--Complications, Outcome, Fatal, Frail Elderly Syndrome
- Trial name
- (ProPEL) (NCT04293653)
- Testing
- Protocol for patients above 75 undergoing emergency laparotomy or laparoscopy
- Where
- Norway
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Appendicitis, Evidence of Cholecystectomy
Point of Care 3D Ultrasound for Various Applications: A Pilot Study
Summary 1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound in obtaining abdominal and/or pelvic images.
- Conditions
- Appendicitis, Evidence of Cholecystectomy, Gallstones, Pregnancy, Ectopic
- Trial name
- NCT02831556
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Duke University
Motility Disorder, Gastroparesis
Body Surface Gastric Mapping to Evaluate Patients With Upper Gastrointestinal Symptoms and Controls
This is an analytical validation observational cohort study is designed to provide evidence of: safety and reliability of Body Surface Gastric Mapping using the Gastric Alimetry System (GAS), normal reference values, and…
- Conditions
- Motility Disorder, Gastroparesis, Functional Dyspepsia, Cyclical Vomiting
- Trial name
- NCT05812339
- Testing
- Gastric Alimetry System
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Diarrhea Infectious, Seizures
Pilot Trial of a Clinical Decision-Support App for Managing Emergencies Among Clinicians in a Rural Ugandan Hospital
This study is testing a new mobile application called the OASES App, developed by the University of Milano-Bicocca. The App is designed to help frontline clinicians (nurses, clinical officers, and nursing assistants) provide…
- Conditions
- Diarrhea Infectious, Seizures, Emergency Care, Clinical Decision Support Systems
- Trial name
- OASES (NCT07257705)
- Testing
- OASES App
- Where
- Uganda
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Reflux Esophagitis
24 Hour Esophageal and Electrogastrography to Investigate the Mechanism of Reflux Esophagitis
We hypothesize that gastric dysrhythmias may predispose the occurrence of gastroesophageal reflux.
- Trial name
- NCT00154570
- Testing
- EGG, 24 hour esophageal pH monitor
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Functional Gastrointestinal Disorders
Prevalence and Associated Factors of Functional Gastrointestinal Disorders Among Children
The definition of Functional Gastrointestinal Disorders (FGIDs) has changed over time from the absence of organic disease to a stress-related or psychiatric disorder to a motility disorder, and with Rome III, to a disorder of GI…
- Trial name
- NCT05605405
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Assiut University
Presbyphagia, Abnormal Tongue Pressure
Effect of Biofeedback Tongue Strengthening Program on Tongue Pressure and Swallowing Performance
Aging is often accompanied by a decline in bodily functions, including the swallowing process. Tongue-strengthening exercises have been shown to improve tongue strength and thickness in healthy adults and the elderly, thereby…
- Trial name
- NCT07080996
- Testing
- Strengthening training with biofeedback, Endurance training with biofeedback
- Where
- Thailand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dysphagia
Assess the Safety and Efficacy of the 4 Channel NMES, Pilot Study
This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders.
- Trial name
- NCT03664479
- Testing
- 4 channel Electrical Stimulation Device
- Where
- South Korea
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
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