Clinical trials: Gastro-Intestinal Disorders
Gastro-esophageal Reflux
Evaluation of Esomeprazole in Treating Gastro-esophageal Reflux Disease (GERD) in Head and Neck Cancer Patients Exposed to Radiation Therapy
The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer.
- Trial name
- NCT00222079
- Testing
- Esomeprazole (Nexium)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Douglas Trask
Gastroesophageal Reflux Disease (GERD)
Correlation of Oropharyngeal Pepsin and Gastroesophageal (GE) Reflux
The purpose of this research study is to see if GE reflux events are associated with increasing levels of pepsin in spit samples. Pepsin is a special protein called an "enzyme" that is made only in your stomach.
- Trial name
- Pepsin (NCT01091805)
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Brain Cancer, Breast Cancer
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types.
- Conditions
- Brain Cancer, Breast Cancer, Bladder Cancer, Cervical Cancer
- Trial name
- CAMPERR (NCT05366881)
- Where
- 17 sites in United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Adela, Inc
Diabetic Ketoacidosis, Heart Disease, Ischemic
Effectiveness of Music Intervention on Anxiety and Physiological Responses in Critical Ill Patient
Music intervention is a non-pharmacological and effective intervention that can alleviate anxiety and agitation in patients undergoing weaning.
- Conditions
- Diabetic Ketoacidosis, Heart Disease, Ischemic, Stroke, GastroIntestinal Bleeding
- Trial name
- NCT04977011
- Testing
- relaxing music
- Where
- Taiwan
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Min-Sheng General Hospital
Gastric Cancer
Novel Screening Modality for Early Gastric Cancer
Potential patients will be recruited at participating sites based on routine care with clinical indications for upper endoscopy.
- Trial name
- NCT04114006
- Where
- Honduras
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy
The goal of this observational study is to learn whether bile acids and pepsin in saliva can help identify adults at higher risk of developing reflux-related esophageal disease after sleeve gastrectomy, including Los Angeles…
- Conditions
- Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy, Saliva Collection, Reflux Esophagitis (RE)
- Trial name
- ABSORB (NCT07607067)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Nausea, Gastroparesis
Cereset Research For Chronic Nausea
This study will explore the use of Cereset Research for symptoms associated with refractory chronic nausea in patients with gastroparesis (GP) in a randomized, clinical trial.
- Conditions
- Nausea, Gastroparesis, Stress, Anxiety
- Trial name
- NCT05229107
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Lingual Tonsil Hypertrophy, Dysphagia
Lingual Tonsil Hypertrophy Grading and Its Relation to Sociodemographic Factors and Clinical Symptoms
The aim of this research was to evaluate the lingual tonsil hypertrophy (LTH) grading of patients with dysphagia using videolaryngoscopy and determine the relation of LTH grades to sociodemographic factors and clinical symptoms.
- Trial name
- NCT02926014
- Testing
- Videolaryngoscopy, Reflux Symptom Index Questionnaire, Dysphagia Screening Questionnaire
- Where
- Lithuania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Minor Digestive Disorders
Prevention of the Minor Digestive Disorders by Lactobacillus Reuteri Supplementation
Aim of the study. To evaluate if L. reuteri DSM 17938 supplementation since the first days of life can reduce the onset of gaseous colic in neonates and the onset of minor digestive disorders such as regurgitation and…
- Trial name
- NCT01235884
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Italy
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University of Bari
Gastroesophageal Reflux Disease
A Study to Compare PK, PD and Safety of the AD-214 10/600mg and Rabeprazole
A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214 10/600mg to Rabeprazole 10mg in healthy volunteers.
- Trial name
- NCT04494243
- Testing
- AD-214 10/600mg, Rabeprazole 10mg
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
GERD
A Study to Monitor Intragastric pH in Patients Taking Rabeprazole vs. Patients Taking Pantoprazole
The purpose of the study is to demonstrate in patients that oral rabeprazole produces equivalent acid suppression to intravenous pantoprazole on Day 1 of drug administration.
- Trial name
- NCT00378287
- Testing
- rabeprazole sodium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Janssen-Ortho Inc., Canada
Testicular Cancer, Colorectal Neoplasms
Diagnostic Yield of Colonoscopy Surveillance in Testicular Cancer Survivors Treated With Platinum-based Chemotherapy
Testicular cancer (TC) survivors treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC) (hazard ratio (HR) 3.9 for platinum-containing chemotherapy versus no platinum-containing chemotherapy…
- Trial name
- CATCHER (NCT04180033)
- Testing
- Colonoscopy surveillance
- Where
- 4 sites in Netherlands
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Lynch Syndrome, Neoplasms
The GEOLynch Cohort Study
The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
- Conditions
- Lynch Syndrome, Neoplasms, Hereditary Nonpolyposis Colorectal Cancer, Colorectal Neoplasms
- Trial name
- GEOLynch (NCT03303833)
- Testing
- No intervention, observational study.
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Gastroesophageal Reflux
Coordination Versus Pressure in Oesophageal Peristalsis
High Resolution Manometry (HRM) is a new advance in oesophageal measurement that permits the acquisition of pressure data through the entire length of the oesophagus over time via closely spaced sensors that continuously record…
- Trial name
- NCT00482885
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Dysphagia, Swallowing Disorders
Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
This multi-site trial will follow a cohort of Veterans with dysphagia for 8 weeks as they undergo clinically guided oropharyngeal exercises with oropharyngeal strengthening as the primary goal.
- Trial name
- NCT04569097
- Testing
- standard of care lingual strengthening
- Where
- 3 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson's Disease, Dysphagia
Efficacy of Voice Treatment for Parkinson's Disease
The purpose of the research study is to determine the effects of two different kinds of speech treatment on certain behaviors in individuals with parkinson's disease.
- Conditions
- Parkinson's Disease, Dysphagia, Dysarthria
- Trial name
- NCT00123084
- Testing
- Voice/Respiration Treatment, Speech/Articulation Treatment
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Gut Inflammation, Overweight and Obese Volunteers
Probiotics Use and Preventing Gastrointestinal Symptoms in People Living With Overweight and Obesity.
Inflammatory bowel disease (IBD) affects over 6.8 million people worldwide, with current treatments often causing side effects and poor patient compliance.
- Trial name
- NCT07253155
- Testing
- Probiotic Arm
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Obesity
Direct Measurement of Ingestive Behaviour in Relation to Sex Differences and Gastrointestinal Hormone Levels in Patients After Metabolic and Bariatric Surgery
Bariatric surgery (BS), especially procedures like Sleeve Gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), is the most effective treatment for obesity.
- Trial name
- DIBASH (NCT06538948)
- Testing
- Bariatric Surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Zurich
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.