Clinical trials: Gastro-Intestinal Disorders
Gastrointestinal Cancers
DPD Guided 5-FU Precision Treatment in Gastro-intestinal Cancer Patients
Rationale: Fluorouracil (5-FU) are broadly used in chemotherapeutic regimens for the treatment of cancers. Dihydropyrimidine dehydrogenase (DPD) is a major enzyme in the 5-FU metabolism pathway.
- Trial name
- COMBIGaPP (NCT06782022)
- Testing
- 5-Fluoro-Uracil
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Jan Gerard Maring
Gastrointestinal Health
Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions
US residents who have gastrointestinal issues sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of three arms.
- Trial name
- NCT05465629
- Testing
- VIOME Precision Nutrition Program, VIOME-designed condition-based supplements
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Viome
Gastroesophageal Reflux
Gastro-intestinal Physiology After Anti-Reflux Procedures
Gastro-oesophageal reflux disease (GORD) affects 1 in 4 adults and is a condition where stomach acid leaks back up into the oesophagus (gullet).
- Trial name
- GASP (NCT05238636)
- Testing
- Anti-reflux surgery - Stretta procedure or LINX device or laparoscopic fundoplication
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- St George's, University of London
Gastrointestinal Microbiome
Cognition and Gut Microbiome Associated Study of Shanghai People With Acute Ischemic Stroke
The purpose of this study is to evaluate the effect of probiotics on the gut microbiome of ischemic stroke patients.
- Trial name
- NCT03812445
- Testing
- Probiotics
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
MUC1-expressing Advanced, Relapsed and/or Refractory Solid Tumors, Non-Small Cell Lung Cancer
Evaluation of XYA02 in Patients With Advanced Solid Tumors
This study will evaluate the safety, tolerability, and efficacy of XYA02 in participants with advanced solid tumors.
- Conditions
- MUC1-expressing Advanced, Relapsed and/or Refractory Solid Tumors, Non-Small Cell Lung Cancer, Ovarian Cancer, GEJ Adenocarcinoma
- Trial name
- NCT07670312
- Testing
- XYA02
- Where
- 5 sites in Australia
- Volunteers
- 190 people
- Sponsor
- XYone Therapeutics, Inc
Obesity, Bariatric Surgery Candidate
Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction
Background: Laparoscopic sleeve gastrectomy (LSG) is one of the commonest bariatric procedures. However, it is associated with postoperative gastroesophageal reflux disease (GERD) and erosive esophagitis (EE).
- Conditions
- Obesity, Bariatric Surgery Candidate, Esophagus Injury, Gastroesophageal Reflux
- Trial name
- REPAIR (NCT05330910)
- Testing
- Laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair arm, Laparoscopic sleeve gastrectomy arm
- Where
- 2 sites in Singapore
- Volunteers
- 96 people
- Sponsor
- Sengkang General Hospital
Functional Gastrointestinal Disorders
Transcutaneous Electric Nerve Stimulation (TENS) for Vagal Modulation
This study is to determine if the auricular microstimulator produces the expected increase in HRV.
- Trial name
- NCT05987813
- Testing
- TENS Unit
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Eating, Obesity
Repetitive Brake Activation
The appearance of intact macronutrients in the small intestine induces an intestinal brake; a negative feedback mechanism from different parts of the intestine to the stomach, the small intestine and to the central nervous…
- Conditions
- Eating, Obesity, Ileal Brake
- Trial name
- NCT02511366
- Testing
- Ileal infusion of casein, Ileal infusion of tap water
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Gastroesophageal Reflux
Examine National Characteristics & Outcome Measures of GERD Patients Using the PPI Acid Suppression Symptom (PASS) Test for Response
To characterize the burden of disease in GERD patients of prescription therapy'
- Trial name
- NCT00392002
- Testing
- Esomeprazole
- Where
- 2 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Insulin Resistance, Inflammatory Bowel Diseases
Nutraceutical Composition Containing Natural Products Derivatives on the Modulation of the Endocrine Neuroimmune Axis
The use of natural products in the prevention or treatment of chronic diseases is an emerging field in current medicine. And studying the mechanisms of actions by which natural products act in our bodies contributes to the…
- Conditions
- Insulin Resistance, Inflammatory Bowel Diseases, Overweight and Obesity, Healthy
- Trial name
- NCCNPDMENA (NCT04810572)
- Testing
- Composition with Silymarin, Low-mineral composition without Silymarin
- Where
- Brazil
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Deglutition Disorders, Lateral Medullary Syndrome
Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
The goal of this observational study is to detect the alteration of cortical activation and functional connectivity during swallowing in patients with Lateral Medullary Syndrome (LMS) dysphagia by functional near infrared…
- Trial name
- NCT06208020
- Testing
- Functional near-infrared spectroscopy (fNIRS) detection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Colorectal Cancer, Ovarian Carcinoma
Intraperitoneal LSTA1 in CRS-HIPEC
This Study is designed to test an investigational product (IP) called LSTA1 (Study drug). LSTA1 is a drug designed to improve the delivery of anti-cancer treatments, such as chemotherapy.
- Conditions
- Colorectal Cancer, Ovarian Carcinoma, Appendix Cancer, Peritoneal Metastases
- Trial name
- NCT06216561
- Testing
- CRS-HIPEC + LSTA1, CRS-HIPEC alone
- Where
- United States
- Sponsor
- University of California, San Diego
Achalasia
Hot Water Drinking Therapy in Achalasia
From clinical observation that some achalasia patients drink water to help swallow food, the investigators have proposed a systemic hot water drinking therapy.
- Trial name
- AHW (NCT01863966)
- Testing
- hot water drinking therapy, Pneumatic dilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Stomach Neoplasms, Colonic Neoplasms
Efficacy and Safety of a Preoperative Aerobic Exercise Program in Patients With Gastrointestinal Cancer.
Patients with gastrointestinal cancer often experience physical deconditioning; this could lead to an increased risk of complications, especially when they require major abdominal surgical procedures.
- Conditions
- Stomach Neoplasms, Colonic Neoplasms, Rectal Neoplasms, Liver Neoplasm
- Trial name
- NCT03423056
- Testing
- Preoperative exercise program
- Where
- Colombia
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Cancerologia, Columbia
Obesity & Overweight
Effects of Posterior Gastropexy During Sleeve Gastrectomy on Quality of Life
This randomized controlled trial evaluates the clinical outcomes and quality of life in patients undergoing laparoscopic sleeve gastrectomy with or without posterior gastropexy.
- Trial name
- GP-LSG (NCT07861529)
- Testing
- Laparoscopic Sleeve Gastrectomy with Posterior Gastropexy, Standard Sleeve Gastrectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Helwan University
Dysphagia, Stroke
Dysphagia Evaluation After Stroke- Effect Oral Neuromuscular Training on Swallowing Dysfunction
The aim of this study is to investigate the effect of a specific rehabilitation program with an oral device used in stroke patients with persistent oral-and pharyngeal dysphagia.
- Trial name
- DESIRE (NCT02960737)
- Testing
- Oral neuromuscular training using an oral device
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Umeå University
PARKINSON DISEASE (Disorder), Parkinson Disease
Italian Translation and Validation of the GIDS-PD Scale for Parkinson's Disease
This study aims to translate and validate the Gastrointestinal Dysfunction Scale for Parkinson's Disease (GIDS-PD) into Italian to enable the assessment of gastrointestinal symptoms in Italian-speaking patients with Parkinson's…
- Trial name
- GIDS-PD_ITA (NCT07316751)
- Where
- 5 sites in Italy
- Volunteers
- 190 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Colorectal Cancer, Non-small Cell Lung Cancer
GEN1029 (HexaBody®-DR5/DR5) Safety Trial in Patients With Malignant Solid Tumors
The purpose of the trial is to evaluate the safety of GEN1029 (HexaBody®-DR5/DR5) in a mixed population of patients with specified solid tumors
- Conditions
- Colorectal Cancer, Non-small Cell Lung Cancer, Triple Negative Breast Cancer, Renal Cell Carcinoma
- Trial name
- NCT03576131
- Testing
- GEN1029 (HexaBody®-DR5/DR5)
- Where
- 6 sites in United States, Spain and 1 more
- Volunteers
- 48 people
- Sponsor
- Genmab
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