Clinical trials: Gastro-Intestinal Disorders
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of SGN-B6A in Chinese Participants With Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) to find out whether it is safe for Chinese participants who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma
- Trial name
- NCT06549816
- Testing
- sigvotatug vedotin
- Where
- 3 sites in China
- Volunteers
- 6 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
GERD
Novel Endoluminal Clinical TreAtment of Reflux
This is a prospective, multi-center, double-blind, crossover, randomized controlled trial designed to demonstrate the safety and efficacy of Aluvra for the treatment of GERD.
- Trial name
- NECTAR (NCT03090607)
- Testing
- Aluvra™, Saline
- Where
- 10 sites in United States
- Volunteers
- 100 people
- Sponsor
- Impleo Medical Inc.
Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery
Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period
Patients undergoing gynecological surgery are at high risk of developing postoperative sleep disorders. Intraoperative opioid use is detrimental to the patient's postoperative recovery of gastrointestinal function.
- Trial name
- NCT05715671
- Testing
- esketamine
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Zhuan Zhang
Neurotoxicity, Gastrointestinal Neoplasms
Clinical Trial of Electroacupuncture Stimulation on Prevention and Treatment of Oxaliplatin Neurotoxicity
The clinical trail of electroacupuncture combined with oxaliplatin regimen on gastrointestinal carcinoma.This trail is randomized controled.Patients are diagnosed gastrointestinal cancer based on pathology or cell biology.They…
- Trial name
- NCT03330964
- Testing
- electro-acupuncture
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Dysphagia
PRO-ACTIVE: Prophylactic Swallow Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer
Dysphagia (difficulty swallowing) is a common and potentially life-threatening toxicity of radiotherapy (RT) for patients with head and neck cancer (HNC).
- Trial name
- PRO-ACTIVE (NCT03455608)
- Testing
- RE-ACTIVE, PRO-ACTIVE EAT, PRO-ACTIVE EAT + EXERCISE
- Where
- 13 sites in United States, Canada
- Volunteers
- 952 people
- Sponsor
- University Health Network, Toronto
Chronic Cough, Extraesophageal Reflux
Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic Cough
Chronic cough is a very unpleasant symptom, significantly reduces the patient's quality of life, and bothers the neighborhood. A very common cause or co-factor of chronic cough is extraesophageal reflux (EER).
- Conditions
- Chronic Cough, Extraesophageal Reflux, Laryngopharyngeal Reflux, Allergy
- Trial name
- NCT04984304
- Testing
- Lifestyle modifications and Antireflux diet, Extraesophageal reflux diagnostic
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
GERD
Understanding the Pathophysiology and Effects of Diaphragmatic Breathing in Upright Gastroesophageal Reflux
This study aims to understand why patients have predominantly upright gastroesophageal reflux disease by comparing such patients to healthy persons AND whether a behavioral intervention (diaphragmatic breathing) will impact this…
- Trial name
- NCT02972047
- Testing
- Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastrointestinal Stromal Tumors
Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)
Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)
- Trial name
- NCT00812240
- Testing
- Masitinib, Imatinib
- Where
- 41 sites in United States, France and 1 more
- Volunteers
- 335 people
- Sponsor
- AB Science
Gastric Ulcers Duodenal Ulcers Caused by Low-dose Aspirin
Long-term Prevention of Recurrent Gastric or Duodenal Ulcers Caused by Low-dose Aspirin With Rabeprazole (E3810) Treatment (Planetarium Study)
The primary objective of this study to examine the long-term safety of rabeprazole 5 mg or 10 mg tablets administered once daily in participants who were confirmed to have no recurrence of gastric or duodenal ulcer by endoscopic…
- Trial name
- NCT01398410
- Testing
- Rabeprazole
- Where
- 50 sites in Japan
- Volunteers
- 405 people
- Sponsor
- Eisai Co., Ltd.
Gastric Cancer, Intestinal Metaplasia
New Classification of Stomach Using Probe-based Confocal Laser Endomicroscopy
The aim of the present study was to propose a new pCLE classification of gastric pit patterns and vessel architecture, and to assess the accuracy and interobserver agreement of this new pCLE classification system in the stomach.
- Conditions
- Gastric Cancer, Intestinal Metaplasia, Atrophic Gastritis, Inflammation
- Trial name
- NCT01896310
- Testing
- probe-based confocal laser endomicroscopy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Shandong University
Peptic Ulcers
Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population
The aim of the current study is to replicate the COXA-0508-258 study in a multicenter, US setting, using a lower dose of ASA. It is expected that this study will not only confirm the results of the 258 study but show that the…
- Trial name
- NCT00137033
- Testing
- Celecoxib, Naproxen, ASA
- Where
- 23 sites in United States
- Volunteers
- 605 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Barrett's Esophagus, Obesity
Modulation of Esophageal Inflammation in Barrett's Esophagus by Omega-3 Fatty Acids
This study is being done to understand the effect of dietary omega-3 fats in decreasing tissue inflammation in Barrett's esophagus.
- Trial name
- NCT01733147
- Testing
- Omega-3 polyunsaturated fatty acids
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Dysphagia
Use and Acceptability Study of Swallis DSA™ Device for Distanced Swallowing Assessment for Older Adults In Nursing Home CHEZ LES PERSONNES AGEES EN EHPAD
SWALL EHPAD is a multicenter, prospective study on the use and Acceptability Study of Swallis DSA™ Medical Device for Distanced Swallowing Assessment for Older Adults In Nursing Home
- Trial name
- SWALL EHPAD (NCT05366374)
- Testing
- Swallowing assessment with Swallis DSA™ Device
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Swallis Medical
Lynch Syndrome
High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome.
Adenomas in Lynch syndrome have an accelerated progression to colorectal cancer (CRC) which might occur despite a regular follow-up.
- Trial name
- EndoLynch (NCT02951390)
- Testing
- High-definition white-light endoscopy
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Clinic of Barcelona
Dysphagia
Neuromuscular Electroestimulation and Respiratory Muscle Training in Subacute Stroke
This study, part of a larger research project (The Retornus Study), is aimed to evaluate new strategies to optimize rehabilitation outcomes in dysphagic stroke patients.
- Trial name
- NCT02473432
- Testing
- RMT + usual care, NMES, Usual care
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Parc de Salut Mar
Postoperative Complications, Psychosomatic Disorder
Development of Machine Learning Models for the Prediction of Complications After Colonic, Colorectal and Small Intestine Anastomosis in Psychiatric and Non-psychiatric Patient Collectives (P-Study)
Our study aims to lay the basis for a predictive modeling service for postoperative complications and prolonged hospital stay in patients suffering from psychiatric diseases undergoing colorectal surgery.
- Conditions
- Postoperative Complications, Psychosomatic Disorder, Psychiatric Disorder, Cancer
- Trial name
- NCT05257863
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer
Domestic Surgical Robot Clinical Study
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Conditions
- Gastric Ulcer With Perforation But Without Obstruction, Colon Cancer, Cholecystolithiasis, Appendicitis
- Trial name
- NCT02752698
- Testing
- Micro Hand S robotic surgery, laparoscopic surgery, da Vinci robotic surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Dysphagia
External Pharyngeal Exerciser and Dysphagia
The goal of this a clinical trial is to test the effect of a pharyngeal exerciser in rehabilitation of pharyngeal phase of swallowing in patients with dysphagia.
- Trial name
- NCT05708898
- Testing
- Pharyngeal exerciser
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Cerebrovascular Disorders, Deglutition Disorders
Stroke Swallowing Screening Tool Validation
Stroke is a major medical problem in the United States, and veterans are at significant risk given that the most critical risk factors of stroke, older age and associated medical problems such as high blood pressure, are common.
- Trial name
- SSST (NCT01559649)
- Testing
- Establishing Validity and Reliability
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
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