Clinical trials: Gastro-Intestinal Disorders
Gastroesophageal Reflux
Gastroesophageal Reflux During LMA in Control Ventilation (LMA, Laryngeal Mask Airway)
Laryngeal mask airway is seldom used for control ventilation in America, while it is popular in China. The question is whether the incidence of gastroesophageal reflux in control ventilation is really higher than in spontaneous…
- Trial name
- LMA (NCT02441257)
- Testing
- control ventilation, spontaneous ventilation
- Volunteers
- 200 people
- Sponsor
- Zhenmeng Wang
Peptic Ulcer, Helicobacter Pylori Infection
The Prevalence of Helicobacter Pylori in Shanghai, 2013 to 2019
The study was a cross-sectional single-center study, conducted at Renji Hospital, Shanghai Jiaotong university school of medicine.
- Trial name
- NCT04636866
- Testing
- NO intervention
- Where
- China
- Volunteers
- 400,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Proximal Gastric Adenocarcinoma, Gastric Cancer
Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer
This research is designed to compare proximal gastrectomy anterior anastomosis with pyloroplasty with esophagogastric anastomosis for gastric cancer.
- Conditions
- Proximal Gastric Adenocarcinoma, Gastric Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT05514769
- Testing
- Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanchong Central Hospital
Sore Throat, Dysphagia
LMA Cuff Pressure and LMA-induced Complications
The purpose of this study is to determine if using 20 mL B.Braun syringes to inflate LMAs and allowing them to recoil will put the pressure of the LMA cuff within the safety range.
- Conditions
- Sore Throat, Dysphagia, Dysphonia
- Trial name
- NCT01385969
- Testing
- Standard inflation of LMA cuff, Pressure check with syringe recoil, Pressure check by pressure transducer
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Disease (GERD)
GERD affects roughly 20% of the U.S. population and the direct and indirect costs of GERD are substantial, totaling close to 50 billion dollars per year.
- Trial name
- NCT04960566
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Peptic Ulcer Disease
Inventory of Inappropriate Prescriptions of Proton Pump Inhibitors (PPIs) in People Over 75 Years of Age
This study would have as a starting point the results of a request carried out by the Medical Service Grand Est of the Health Insurance aiming to evaluate the number of boxes of PPI reimbursed in town pharmacy, in patients over…
- Trial name
- Etaliepre-IPP (NCT05618249)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Esophagitis, Reflux
Clinical Trial of Reconstruction After Proximal Gastrectomy
1) To explore a simple, safe, post-proximal gastrectomy reconstruction method with good absorption and digestive function in order to improve patients' postoperative quality of life; 2) To fill the gap in the comparison of…
- Trial name
- NCT05418920
- Testing
- left-opening single-flap technique, double-flap group technique
- Volunteers
- 250 people
- Sponsor
- Oncogastroenterology Committee of Chinese
Dysphagia
Outpatient Swallowing Therapy for Subjects With Neurological Illness
Health care staff in the municipalities do not always have the necessary competencies to treat patients with dysphagia. At the present neurorehabilitation hospital dysphagia examinations for outpatients are provided.
- Trial name
- NCT04595643
- Testing
- Combination of different dysphagia training modalities
- Where
- Denmark
- Volunteers
- 5 people
- Sponsor
- University of Aarhus
Taste Disorder, Secondary, Sweet
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides
The purpose of this study is to determine the functional significance of sweet taste receptors in the secretion of gastrointestinal (GI) satiation peptides by using a specific sweet taste receptor antagonist to block sweet taste…
- Trial name
- NCT01302574
- Testing
- lactisole
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Rectal Neoplasms
Exercise Training for Rectal Cancer Patients
Cancer treatments often cause acute toxicity during treatment, and late toxicity after treatments have ended. Bowel dysfunctions, incontinence (anal and urinary) and dysfunction are late side effects associated with cancer…
- Trial name
- NCT02538913
- Testing
- Exercise training, Usual care
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Allergic Contact Dermatitis, Metal Allergy
Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases
The goal of this clinical trial is to collect environmental, bio-humoral, and clinical data derived from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes related to the exposure to heavy…
- Conditions
- Allergic Contact Dermatitis, Metal Allergy, Food Allergy, Nickel Sensitivity
- Trial name
- MATRIOSKA (NCT06529913)
- Testing
- Collection of environmental, biological, and clinical data
- Where
- 2 sites in Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ischaemic Stroke, Hemorrhagic Stroke
Exploratory Study on the Potential Cross-System Effects of BCI-FES Hand Therapy on Dysphagia and Aphasia in Chronic Stroke Patients
The goal of this neurorehabilitation explorative study is to investigate how a closed-loop Brain-Computer Interface Functional Electrical Stimulation (BCI-FES) therapy, used within the intended purpose for hand rehabilitation…
- Trial name
- c-STEPS (NCT06940635)
- Testing
- closed-loop BCI-FES device
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- VASCage GmbH
Lung Neoplasms, Breast Neoplasms
PERCIST Criteria for Response Evaluation With Solid Tumors
Chemo-radiotherapy and targeted therapy are widely used as non-surgical treatments for solid tumors. Early assessment of treatment response is considered efficient and helpful to clinical management and personalized…
- Conditions
- Lung Neoplasms, Breast Neoplasms, Colonic Neoplasms, Lymphoma
- Trial name
- NCT02765620
- Testing
- drug&radiation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Prostate Cancer, Breast Cancer
Collection of Patient-Reported Symptoms and Performance Status Via the Internet
This pilot clinical trial studies how well using the internet to collect symptoms and the ability to carry out daily activities works in patients with enrolled on Cancer and Leukemia Group B (CALGB) studies.
- Conditions
- Prostate Cancer, Breast Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- NCT00417040
- Testing
- internet-based intervention, assessment of therapy complications, Questionnaire Administration
- Where
- 95 sites in United States
- Volunteers
- 325 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ovarian Neoplasms, Pancreatic Neoplasms
A Safety, Efficacy and Pharmacokinetic Study of Siltuximab (CNTO 328) in Participants With Solid Tumors
The purpose of this study is to determine the recommended dose of siltuximab monotherapy, in participants with solid malignant (cancerous) tumors (a mass in a specific area) and to estimate the clinical benefit of siltuximab…
- Conditions
- Ovarian Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT00841191
- Testing
- CNTO 328; Anti-interleukin-6 monoclonal antibody
- Where
- 12 sites in United States, Belgium and 3 more
- Volunteers
- 84 people
- Sponsor
- Centocor, Inc.
Amyotrophic Lateral Sclerosis, Dysphagia
Fatigue in Patients With Amyotrophic Lateral Sclerosis
Expiratory muscle strength training (EMST) is an emerging palliative intervention for prolonging pulmonary and swallow function in patients with amyotrophic lateral sclerosis (PALS), but it is unknown whether EMST may result in…
- Conditions
- Amyotrophic Lateral Sclerosis, Dysphagia, Dyspnea, Respiration Disorders
- Trial name
- NCT04468191
- Testing
- Experimental expiratory muscle strength training (EMST)
- Where
- United States
- Sponsor
- Cara Donohue
Achalasia
Per-Oral Endoscopic Esophagomyotomy (POEM)
Achalasia is an esophageal motility disease that usually requires surgical intervention (esophagomyotomy). Laparoscopic techniques have reduced the morbidity associated with myotomy, but post-op GERD, wound infection, hernia and…
- Trial name
- POEM (NCT01635374)
- Testing
- Per-Oral Endoscopic Esophagomyotomy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Northwestern University
Breast Cancer, Chronic Myeloproliferative Disorders
Motexafin Gadolinium and Doxorubicin in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Motexafin gadolinium may increase the effectiveness of doxorubicin by making tumor cells more sensitive to…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Colorectal Cancer, Head and Neck Cancer
- Trial name
- NCT00036790
- Testing
- doxorubicin hydrochloride, motexafin gadolinium
- Where
- 2 sites in United States
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Colorectal Cancer
Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking
RATIONALE: Memantine hydrochloride may help people stop smoking by decreasing the symptoms of nicotine withdrawal. PURPOSE: This randomized, pilot phase II trial studies how effective memantine hydrochloride works compared to…
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT01535040
- Testing
- memantine hydrochloride
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Wake Forest University Health Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.