Clinical trials: Gastro-Intestinal Tolerance
Population With Self-perceived Gastro-intestinal Sensitivity to Fibers
Tolerance Profile of Soluble Fibers in Individuals With Self-perceived GI Sensitivity to Fibers (Tarine)
The purpose of this study is to determine the optimal dose of soluble fibers that induces tolerable gastrointestinal symptoms.
- Trial name
- Tarine (NCT06877013)
- Testing
- Fiber's mix (among 4 doses)
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Healthy
Safety of Larazotide Acetate in Healthy Volunteers
To demonstrate the safety, tolerance and pharmacokinetics of multiple, oral doses of larazotide acetate.
- Trial name
- NCT00386490
- Testing
- larazotide acetate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- 9 Meters Biopharma, Inc.
Lactose Intolerance
A Bifido Bacteria to Improve Lactose Digestion and Tolerance
We want to determine if feeding a bifido bacteria that readily digests lactose and galactooligosacharides improves lactose digestion and tolerance through alteration of the microbiome.
- Trial name
- NCT05668468
- Testing
- Bifidobacterium adolescentis IVS-1 capsule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Diabetes, Malnutrition
Study About Adherence and Tolerance of an Oral Nutritional Supplement (ONS) Specific for Diabetic Patient.
Diabetes Mellitus (DM) is one of the most prevalent chronic diseases today, it is reaching epidemic proportions, mainly caused by the increase in type 2 diabetes (DM2).The foundation of any hypoglycemic treatment is based on a…
- Trial name
- DIABEST (NCT05488210)
- Testing
- FontActiv DiaBest HP/HC
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Milk Intolerance, Milk Hypersensitivity
Goat vs. Cow Milk Digestive Tolerance
The objective of this study is to assess to what extent goat's milk is better tolerated than cow's milk among individuals who report being intolerant to cow's milk, and, if so, to understand the underlying factors.
- Conditions
- Milk Intolerance, Milk Hypersensitivity, Cow Milk Protein Sensitivity
- Trial name
- DIGIGOAT (NCT07239856)
- Testing
- Cow milk, Goat Milk
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Diet Modification
Gastrointestinal Assessment of Three Novel RS4
The rates of chronic diseases like obesity, diabetes, and heart disease are rising across the world. This is especially true in industrialized countries like Canada and the USA.
- Trial name
- NCT03255603
- Testing
- Resistant Starch Type 4 Supplementation, Digestible Starch Supplementation
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Gastrointestinal Tolerance
The Effects of Soluble Corn Fiber on Gastrointestinal Tolerance and Fecal Microbiome in Healthy Children
The purpose of this study is to compare the effects of PROMITOR® Soluble Corn Fiber versus inulin on GI symptoms (tolerance), stool consistency (laxation) and fecal microbiome at levels that could contribute to closing the fiber…
- Trial name
- NCT05213494
- Testing
- Inulin, soluble corn fiber
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle
Gastroesophageal Reflux Disease, Reflux, Gastroesophageal
A Study To Investigate The Effectiveness Of AH234844 (Lavoltidine) Compared With NEXIUM And Ranitidine.
Current treatment for gastroesophageal reflux disease (GERD) confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric-acid suppression.
- Trial name
- NCT00405119
- Testing
- AH23844 (lavoltidine), NEXIUM (esomeprazole), ZANTAC (ranitidine)
- Where
- 2 sites in Australia
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Fat and Sugar Replacer Blends on Gastrointestinal Tolerance in Biscuits
This study is a randomized, double-blind, crossover trial aiming at evaluating the gastrointestinal tolerance and bowel habits of sugar- and fat- replacer ingredients and blends (maltitol, polydextrose, allulose and EPG)
- Trial name
- NCT07372482
- Testing
- Test sandwiched biscuits with creme, Control sandwiched biscuit with sugar
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Gastroesophageal Reflux Disease, Reflux, Gastroesophageal
Open-label Comparison of 24hr Gastric pH on Days 1, 2, 7 With Once-daily Administration of Lavoltidine 40 mg.
Current treatment for gastroesophageal reflux disease(GERD)confirms an unmet need in patients, based on slow onset of action and an inability to provide 24-hour gastric acid suppression.
- Trial name
- NCT00551473
- Testing
- Lavoltidine
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastrointestinal Tolerance
Gastrointestinal Tolerance and Safety of an Infant Formula Containing Prebiotics, Probiotics and Postbiotics.
A study to investigate the gastrointestinal tolerance and safety of a new formula containing prebiotics, probiotics and postbiotics.
- Trial name
- TREE (NCT04745455)
- Testing
- Infant formula containing prebiotics, probiotics and postbiotics
- Where
- 3 sites in Poland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Healthy Infants
Gastrointestinal Tolerance Study of a New Infant Formula
This study is initiated to investigate the gastrointestinal tolerance of a new infant formula in healthy, term, Asian infants.
- Trial name
- BOOGIE (NCT01681355)
- Testing
- Infant Formula
- Where
- 5 sites in Indonesia, Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Healthy, Full-term Infants Who Are Formula-fed
Gastrointestinal Tolerance Evaluation of an Infant Formula
Prospective, double-blind, randomized study of 2 infant formulas.
- Trial name
- NCT03307122
- Testing
- Routine Infant Formula 1, Routine Infant Formula 2
- Where
- 8 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Gastro-Intestinal Tolerance
Evaluation of Carbohydrates Part 2
The study is single-blind with a randomized, cross-over design to evaluate gastrointestinal tolerance of carbohydrate blends.
- Trial name
- NCT03293706
- Testing
- CHO Control 1 and 2 Glucose, CHO Experimental 1 Slowly Digested, CHO Experimental 2 Digestion Resistant
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Post Bariatricsurgery, Hypoglycemia
Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery
RYGB (roux-en-y gastric bypass) has been reported to reverse type 2 diabetes (T2DM) immediately after surgery before any significant weight loss.
- Trial name
- NCT00992901
- Testing
- Exendin-(9-39), Atropine, GLP-1 and GIP
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Infant
Comparative Ca Absorption and Tolerance in Healthy Term Infants Fed Milk-based Formulas With Different Fat Blends
The objective is to assess the comparative calcium absorption and gastrointestinal (GI) tolerance in healthy normal term infants fed two commercially available powdered milk-based formulas which contain different fat blends.
- Trial name
- NCT00941564
- Testing
- Infant Formula milk based
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Healthy
Gastrointestinal Toleration of Inulin Products
The intake of inulin products has been linked to multiple health benefits which has lead to inulin fortification in food products.
- Trial name
- NCT00958529
- Testing
- Inulin Fiber Supplement
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Inflammatory Bowel Diseases
Pharmacokinetics and Pharmacodynamics Clinical Study of VC005 Tablets in Healthy Subjects
This clinical trial consists of two parts：1. a randomized, double-blind, single-center, placebo-controlled, dose-escalation PK study; 2. food effects and drug metabolism transformation study.
- Trial name
- NCT05138770
- Testing
- VC005 Tablets, VC005 Tablets food effects group
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Celiac Disease
A Population-based Study of Celiac Disease in South Europe in Children Between 1 to 5 Years of Age
Celiac disease (CD) was diagnosed for years almost exclusively in children. This is due to the fact that in adulthood it manifests in a much more attenuated form, while the classic form with severe diarrhea, malnutrition and…
- Trial name
- HNCEL (NCT05968404)
- Volunteers
- 3,659 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Food Selection
Effects of Juice on Gastrointestinal Tolerance and Breath Hydrogen Response in Human Subjects
The goal of this study is to determine subjective gastrointestinal tolerance response and differences in breath hydrogen response following the consumption of two types of juice.
- Trial name
- NCT02565472
- Testing
- White grape juice, Apple juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota